Clinical trials: SCI, active
Acute Spinal Cord Injury (SCI), Acute Spinal Cord Injury of Traumatic Origin (tSCI)
Safety of Transcutaneous Electrical Stimulation Potentiating Recovery in Acute Spinal Cord Injury Syndromes
The goal of this study is to test whether electrical stimulation from the skin surface starting 3 days after spinal cord injury (SCI) is safe and may help patients recover their movement.
- Trial name
- STEP-RAISE (NCT07090473)
- Testing
- transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Spinal Cord Injury
Health and Financial Impact on the Use of a Personal Exoskeleton in the Home and Community: a Case Study
The goal of this clinical trial is to examine the long-term use of a personal overground robotic exoskeleton in subjects with spinal cord injury. The main aims of this study include: 1.
- Trial name
- NCT07030322
- Testing
- Overground Robotic Exoskeleton
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ekso Bionics
Spinal Cord Injuries (SCI)
Spatiotemporal tSCS in Spinal Cord Injury
Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in…
- Trial name
- NCT07397559
- Testing
- No Stimulation, Conventional tSCS, Spatiotemporal tSCS
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis
Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia
Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.
- Conditions
- Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis, Spinal Cord Injuries (SCI)
- Trial name
- LEAP (NCT07784088)
- Testing
- IWBCIS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- BCIFlex Medical Technology Co., Ltd.
Spinal Cord Injuries
Living Longer and Stronger With Spinal Cord Injury (SCI)
The purpose of this study is to develop a health promotion group intervention to meet the unique health promotion needs of people aging with SCI, to test the efficacy of the adapted intervention program, Living Longer and…
- Trial name
- LLS (NCT06227000)
- Testing
- Living Longer and Stronger with SCI, Control
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury Cervical, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure.
- Trial name
- NCT07722130
- Testing
- Epidural spinal cord stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Neurogenic Bowel, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury
The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic…
- Trial name
- NCT06801431
- Testing
- Transcutaneous spinal cord stimulation
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Sexual Function Abnormal, Spinal Cord Injuries (SCI)
A Prospective Cohort Study on the Effect of Spinal Spinal Cord Injury on Sexual Function in Male Patients
1. Background and Rationale Spinal cord injury (SCI) represents a devastating neurological condition with multidimensional consequences.
- Trial name
- NCT07093827
- Testing
- Posterior decompression surgery, unilateral open-door laminoplasty, Posterior lumbar discectomy with fusion
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University Third Hospital
Spinal Cord Injuries
Effect of Threshold Pressure-Loaded RMT + tTBS on Respiratory Function in SCI Patients
The purpose of this clinical trial is to understand whether threshold pressure load respiratory muscle training combined with iTBS can effectively improve the respiratory function of SCI patients.
- Trial name
- NCT07050069
- Testing
- Transcranial Magnetic Stimulation (TMS) Device / Respiratory Training Device
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shengjing Hospital
Stroke, Spinal Cord Injuries (SCI)
Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)
Rehabilitation remains important in the chronic phase after stroke or spinal cord injury, as meaningful improvements may still be achieved through intensive, goal-directed, and personalized training.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Chronic Disease
- Trial name
- INTeRAcT-bis (NCT07912320)
- Testing
- Intensive rehabilitation programme
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Neurogenic Bladder
Device for Bladder Control for Men With SCI
Urinary incontinence, bladder frequency, and bladder urgency are significant medical problems for people with overactive bladder (OAB) or neurogenic bladder overactivity (NDO).
- Trial name
- NCT07668063
- Testing
- Noninvasive electrical stimulation device to improve bladder control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate.
- Trial name
- NCT06313515
- Testing
- Transcutaneous Spinal Cord Stimulation, Arm-crank bike exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Incomplete Spinal Cord Injury (SCI)
Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.
The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury.
- Trial name
- tSCS_SJD_PMI_1 (NCT07445685)
- Testing
- Transcutaneous spinal cord stimulation on the dorsal region between T11 and T12
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Sant Joan de Déu
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injuries
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure.
- Trial name
- NCT07222046
- Testing
- Neurophysiological and anatomical testing, Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries (SCI)
The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper…
- Trial name
- NCT07695662
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Spinal Cord Injuries
Epidural Stimulation and Resistance Training After SCI
Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life.
- Trial name
- REST-SCI (NCT04782947)
- Testing
- Exoskeletal assisted walking, Epidural Stimulation, Resistance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Department of Defense
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki