Clinical trials: SCLC, Limited Stage
Non Small Cell Lung Cancer
A Exploratory Study of Nivolumab Monotherapy or in Combination With Nab-paclitaxel and Carboplatin in Early Stage NSCLC in China
Nivolumab (BMS-936558) is a fully human, IgG4 (kappa) isotype mAb that binds PD-1 on activated immune cells and disrupts engagement of the receptor with its ligands PD-L1 (B7 H1/CD274) and PD-L2 (B7-DC/CD273), thereby abrogating…
- Trial name
- NCT04015778
- Testing
- Nivolumab, carboplatin, nab-paclitaxel
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Guangdong Association of Clinical Trials
Lung Cancer
VNP40101M in Treating Patients With Relapsed or Refractory Locally Advanced or Metastatic Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as VNP40101M, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00282022
- Testing
- laromustine
- Where
- 9 sites in United States
- Volunteers
- 87 people
- Sponsor
- Vion Pharmaceuticals
Non-small Cell Lung Cancer
Daily vs. Non-Daily SBRT for NSCLC
The purpose of this study is to determine if stereotactic body radiotherapy (SBRT) on non-consecutive days will increase the chances of curing non-small cell lung cancer when compared to daily treatment.
- Trial name
- NCT03624907
- Testing
- Daily Stereotactic Body Radiotherapy, Non-Daily Stereotactic Body Radiotherapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Non-small Cell Lung Cancer
Pre-Operative Immuno-Modulatory SBRT (POIMS Trial): A Pilot Trial in Early Stage NSCLC
The current proposal is structured as a pilot trial to evaluate the impact of non-ablative SBRT (800 cGy X 3 fractions) as an immunomodulatory mechanism in patients with early stage NSCLC who are surgical candidates.
- Trial name
- POIMS (NCT05094544)
- Testing
- Non-ablative SBRT
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Extensive Stage Small Cell Lung Carcinoma, Limited Stage Small Cell Lung Carcinoma
Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer
This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues…
- Trial name
- NCT02635009
- Testing
- Three-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- 281 sites in United States, Canada
- Volunteers
- 418 people
- Sponsor
- NRG Oncology
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine, Chemotherapy, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00004176
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
NSCLC, Non-small Cell Lung Cancer
Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy
The purpose of this study is to find out whether treatment with the study drug durvalumab combined with a type of radiation therapy called stereotactic body radiation (SBRT) is a more effective treatment for early-stage non-small…
- Conditions
- NSCLC, Non-small Cell Lung Cancer, Lung Cancer, Non-small Cell Lung Cancer Stage I
- Trial name
- NCT04716946
- Testing
- Durvalumab, Stereotactic Body Radiation Therapy
- Where
- 8 sites in United States
- Volunteers
- 13 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer
Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early Stage Peripheral Non-small Cell Lung Cancer
This pilot clinical trial studies the side effects and how well stereotactic radiosurgery followed by wedge resection works in treating patients with early stage non-small cell lung cancer that is located in the outer, or…
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT02250378
- Testing
- stereotactic radiosurgery, therapeutic conventional surgery, laboratory biomarker analysis
- Where
- United States
- Sponsor
- University of Southern California
Small-Cell Lung Cancer (SCLC)
A Study Evaluating Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade for Limited-stage Small Cell Lung Cancer
This study will enroll patients with limited-stage small cell lung cancer (SCLC). Patients will receive chemotherapy (etoposide and platinum-based drugs) combined with dual immune checkpoint blockade (PD-1/CTLA-4) and thymosin…
- Trial name
- NCT07103408
- Testing
- Immuno-chemotherapy, Radiotherapy, Consolidative therapy
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Sun Yat-sen University
SCLC, Limited Stage
Study of Serplulimab Plus Chemotherapy as Neoadjuvant Therapy for Limited-stage Small Cell Lung Cancer (LS-SCLC)
This investigator-initiated, open-label, prospective Phase II clinical trial, planned to take place across multiple centers in China.
- Trial name
- NCT06911606
- Testing
- 4 cycles of Serplulimab combined with etoposide and carboplatin or cisplatin
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Guangdong Provincial People's Hospital
SCLC, Limited Stage, Radiation Exposure
Omitting CTV for Primary Tumor in LS-SCLC
This randomized controlled non-inferior trial prospectively enrolled patients with limited-stage small cell lung cancer (LS-SCLC).
- Conditions
- SCLC, Limited Stage, Radiation Exposure, Radiotherapy Side Effect, Progression
- Trial name
- NCT07008716
- Testing
- Radiation Therapy, Etoposide + carboplatin; Etoposide + cisplatin, Creating CTV for primary tumor
- Where
- 2 sites in China
- Volunteers
- 852 people
- Sponsor
- Sun Yat-sen University
Non-small Cell Lung Cancer
A Study to Evaluate Effectiveness and Safety of Surgeries in Elderly NSCLC Patients
The trial was designed to compare effectiveness and safety of surgeries in the patients with non-small cell lung cancer
- Trial name
- NCT03429673
- Testing
- Surgeries
- Where
- 10 sites in China
- Volunteers
- 10,885 people
- Sponsor
- China-Japan Friendship Hospital
Limited-stage Small Cell Lung Cancer (LS-SCLC), Chemoradiotherapy
A Study of QL1706 Combined With Chemotherapy Induction on Sequential Immunotherapy Consolidation in Patients With Limited-Stage Small Cell Lung Cancer After Chemoradiotherapy
The study is being conducted to evaluation of the Efficacy and Safety of QL1706 Combined with Chemotherapy Induction in Sequential Immunotherapy Consolidation After Concurrent Chemoradiotherapy for Limited-Stage Small Cell Lung…
- Conditions
- Limited-stage Small Cell Lung Cancer (LS-SCLC), Chemoradiotherapy, Induction Therapy, Consolidation Immunotherapy
- Trial name
- NCT07091305
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer Associated With Cystic Airspaces, Multiple Primary Lung Cancers
Multi-omics Study of Early-stage Lung Cancer With Distinct Phenotypes
The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers…
- Conditions
- Lung Cancer Associated With Cystic Airspaces, Multiple Primary Lung Cancers, Non-Small Cell Lung Cancer
- Trial name
- NCT06699979
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Central South University