Clinical trials: SCS
Chronic Pain
Spinal Cord Stimulation Trial to Permanent Prediction
Spinal Cord Stimulation Trial to Permanent Prediction is a prospective, longitudinal, multi-center, non-randomized, multi-arm, open-label, clinical feasibility study designed to investigate whether objective data collected from…
- Trial name
- SCS T2P (NCT05659836)
- Testing
- Abbott Spinal Cord Stimulation (SCS) Systems (Apple Watch® & Oura™ Ring)
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Abbott Medical Devices
Chronic Pain
Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
The purpose of this prospective post market observational pilot study is to evaluate the effect of DRG stimulation in the management of chronic discogenic pain in subjects who are refractory to other available treatments.
- Trial name
- NCT02587637
- Testing
- Dorsal root ganglion (DRG) stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Failed Back Surgery Syndrome, Back Pain
Spinal Cord Stimulation for Predominant Low Back Pain
The purpose of this study is to compare the effectiveness of spinal cord stimulation (SCS) using the Medtronic Specify® 5-6-5 multicolumn surgical lead plus optimal medical management (OMM) versus OMM alone in patients suffering…
- Conditions
- Failed Back Surgery Syndrome, Back Pain, Pain in Leg, Unspecified
- Trial name
- PROMISE (NCT01697358)
- Testing
- Spinal Cord Stimulation (SCS), Optimal Medical Management (OMM)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 278 people
- Sponsor
- MedtronicNeuro
Chronic Pain
Algovita Post-Market Clinical Study: Spinal Cord Stimulation to Treat Chronic Pain
The purpose of this study is to obtain real-world clinical outcome data for the Algovita Spinal Cord Stimulation system when used, on-label, according to the applicable directions for use.
- Trial name
- NCT02373540
- Testing
- Algovita Spinal Cord Stimulation system
- Where
- 18 sites in United States, Germany
- Volunteers
- 91 people
- Sponsor
- Nuvectra
Chronic Pain
Algovita Spinal Cord Stimulation System Hi-Fi Study
The objective of this study is to obtain post-market clinical outcome data for the Algovita SCS System when used on-label, according to the applicable directions for use, using high fidelity tonic stimulation at either ultra-high…
- Trial name
- NCT03622866
- Testing
- Ultra-high pulse width stimulation, Traditional pulse width stimulation
- Where
- 10 sites in United States
- Volunteers
- 20 people
- Sponsor
- Nuvectra
Neovascular Age-related Macular Degeneration
Extension Study to Evaluate the Long-term Outcomes of Subjects in the CLS-AX CLS1002-101 Study
This is an open-label, non-interventional extension study of up to 12 weeks in duration in subjects completing Cohorts 2, 3, and 4 of the Parent study, CLS1002-101.
- Trial name
- NCT05131646
- Testing
- CLS-AX
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- Clearside Biomedical, Inc.
Chronic Pain
Paresthesia-Free Fast-Acting Subperception (FAST) Study
Study to evaluate the effectiveness of FAST-SCS (fast-acting paresthesia-free therapy) and additional SCS therapy options in patients with chronic pain using Boston Scientific WaveWriter SCS Systems.
- Trial name
- FAST (NCT04618471)
- Testing
- Boston Scientific WaveWriter SCS System
- Where
- 13 sites in United States
- Volunteers
- 177 people
- Sponsor
- Boston Scientific Corporation
Chronic Pain
High Rate Spinal Cord Stimulation (SCS) for Chronic Pain
To determine the effects of varying spinal cord stimulation programming parameters, including stimulation rate, on pain intensity.
- Trial name
- NCT01624740
- Testing
- Low Rate Stimulation, High Rate Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation
Chronic Low-back Pain, Chronic Leg Pain
A First in Human Feasibility Study to Evaluate the Safety and Effectiveness of the BIOTRONIK Prospera SCS System with HomeStream Remote Management
The BENEFIT-03 Clinical Study is a first in human, prospective, multi-center, single-arm, interventional feasibility study to be conducted in Australia.
- Trial name
- NCT04683718
- Testing
- Permanent implant of a BIOTRONIK Prospera SCS (Spinal Cord Stimulation) System with HomeStream Remote Management
- Where
- 5 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Biotronik, Inc.
Pain, Intractable, Pain, Chronic
Study to Evaluate Neuromodulation Subject Experience With Contemporary Spinal Cord Stimulation (SCS) Modalities for Chronic Pain
Medtronic, Inc. is sponsoring the SENSE SCS clinical study, a prospective, multi-center, post-market, non-randomized, observational study with a hybrid decentralized model of execution, utilizing a mobile application for the…
- Trial name
- SENSE SCS (NCT05775510)
- Testing
- Commercially available neurostimulation systems
- Where
- 10 sites in United States
- Volunteers
- 91 people
- Sponsor
- MedtronicNeuro
Chronic Low Back and Leg Pain
Spinal Cord Stimulation Research Study
The purpose of this study is to characterize subjects' response to spinal cord stimulation with postural changes.
- Trial name
- NCT00737581
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- MedtronicNeuro
Painful Diabetic Neuropathy
Pain and Neurological Function Improvements With 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy
The purpose of this post-market study is to evaluate changes in pain and neurological function with high frequency, 10 kHz spinal cord stimulation (SCS) therapy in patients with chronic, intractable lower limb pain associated…
- Trial name
- PDN-SENSORY (NCT05777317)
- Testing
- 10 kHz SCS, CMM alone
- Where
- 2 sites in United States
- Volunteers
- 143 people
- Sponsor
- Nevro Corp
Chronic Pain
Objective Assessment of Activity and Sleep Quality In Burst Spinal Cord Stimulation
The purpose of this study is to assess feasibility of using wearable sensors to capture objective assessments of patient's activity and sleep quality during the spinal cord stimulation (SCS) treatment continuum.
- Trial name
- OASIS (NCT02950831)
- Testing
- Accelerometry
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 27 people
- Sponsor
- Abbott Medical Devices
Failed Back Surgery Syndrome, Pain
Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome
The EVIDENCE trial is a randomized controlled trial comparing the therapeutic effectiveness and cost-effectiveness of the Precision® Spinal Cord Stimulation with that of reoperation as a treatment of pain in patients with Failed…
- Conditions
- Failed Back Surgery Syndrome, Pain, Back Pain
- Trial name
- Evidence (NCT01036529)
- Testing
- Precision Spinal Cord Stimulator, Back Surgery
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
ABBV-RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of Diabetic Retinopathy (DR) with and without Center-Involved Diabetic Macular Edema (CI-DME).
- Trial name
- ALTITUDE® (NCT04567550)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, ABBV-RGX-314 Dose 3
- Where
- 25 sites in United States
- Volunteers
- 139 people
- Sponsor
- AbbVie
Pain, Chronic Pain
Efficacy and Safety of Spinal Cord Stimulation in Patients With Chronic Intractable Pain
The purpose of this study is to evaluate the efficacy and safety of spinal cord stimulation (SCS) using the PINS spinal cord stimulator device for chronic and intractable pain.
- Conditions
- Pain, Chronic Pain, Back Pain, Spinal Cord Stimulation
- Trial name
- NCT03858790
- Testing
- PINS Spinal Cord Stimulator
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Chronic Pain
Long-term Effectiveness, Safety, and Performance of the Evoke Closed-Loop SCS System to Treat Patients With Chronic Pain of the Trunk and/or Limbs
The objective of this multicountry, multicentre, prospective study is to evaluate the long-term clinical effectiveness, safety, and performance of the Evoke System in the treatment of chronic pain of the trunk and/or limbs in a…
- Trial name
- Domburg (NCT04627974)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people
- Sponsor
- Saluda Medical Pty Ltd
Chronic Pain, Chronic Low-back Pain
Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain
The Presidio Medical Ultra Low Frequency (ULF™) Spinal Cord Stimulation (SCS) System is intended to provide pain relief to participants who have been clinically diagnosed with chronic low back pain with or without leg pain.
- Trial name
- NCT05837234
- Testing
- ULF SCS
- Where
- 3 sites in Australia
- Volunteers
- 55 people
- Sponsor
- Presidio Medical, Inc
Asthma
Retrospective Analysis of Systemic Glucocorticoid Mediated Long-term Effects, Patient Pathways and Economic Burden Across Multiple Indications
Glucocorticoids are important in the treatment of many inflammatory, allergic, immunologic, and malignant disorders. However, the adverse effects of systemic corticosteroids are one of the most common causes of iatrogenic…
- Trial name
- NCT06488703
- Where
- Germany
- Volunteers
- 107,032 people
- Sponsor
- GlaxoSmithKline
Pain, Intractable Pain
Efficacy of the Spinal Cord Stimulation System as Salvage Therapy
The primary objective of this study is to evaluate the efficacy of spinal cord stimulation using the Precision implantable neurostimulation device for chronic and intractable pain of the trunk and or limbs in patients who have…
- Conditions
- Pain, Intractable Pain, Chronic Pain
- Trial name
- NCT00387244
- Testing
- Precision for Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Boston Scientific Corporation