Clinical trials: SLE Nephritis
Systemic Lupus Erthematosus (SLE), Lupus Nephritis (LN)
A Study to Evaluate MTM-H-001 Injection in Adult Patients With B-Cell-Related Autoimmune Diseases
This is an investigator-initiated, open-label, single-arm, dose-escalation and dose-expansion study to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of MTM-H-001 in adult participants with B-cell-related…
- Conditions
- Systemic Lupus Erthematosus (SLE), Lupus Nephritis (LN), Multiple Sclerosis, Myasthenia Gravis (MG)
- Trial name
- ArchAid-002 (NCT07593911)
- Testing
- MTM-H-001 Injection
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing GoBroad Hospital
Lupus Nephritis
A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Lupus Nephritis Previously Enrolled in Study U2970g
This is a Phase III, multicenter, extension study to evaluate the safety of rituximab administered on a scheduled basis approximately every 6 months.
- Trial name
- NCT00404157
- Testing
- Rituximab
- Sponsor
- Genentech, Inc.
Lupus Nephritis
Clinical Trial Treatment in Lupus Nephritis
The treatment of lupus nephritis with cyclophosphamide and steroids changed the prognosis of lupus nephritis in the early '80s. In recent years, alternative regimens have appeared in both the induction and maintenance with…
- Trial name
- Csa-LES (NCT01299922)
- Testing
- cyclosporine +mycophenolic acid+prednison, Mycophenolic Acid + prednison
- Where
- Spain
- Sponsor
- Hospital Universitario Fundación Alcorcón
Systemic Lupus Erythematosus, Lupus
CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy, in Patients With Refractory Systemic Lupus Erythematosus (GALLOP)
This is a Phase 1 study to evaluate the safety and efficacy of a single infusion of CB-010 in patients with refractory Systemic Lupus Erythematosus (SLE) with cohorts for lupus nephritis (LN) and extrarenal lupus (ERL).
- Conditions
- Systemic Lupus Erythematosus, Lupus, Lupus Erythematosus, Lupus Nephritis
- Trial name
- GALLOP (NCT06752876)
- Testing
- CB-010
- Sponsor
- Caribou Biosciences, Inc.
Lupus Nephritis
Comparison Between Tacrolimus (TAC) and Mycophenolate Mofetil (MMF) for Induction of Remission in Lupus Nephritis
Prospective, multi-center, randomized, controlled, trial to compare tacrolimus with mycophenolate mofetil (MMF) for induces complete remission in lupus nephritis patients. The study duration is one year.
- Trial name
- NCT01580865
- Testing
- Tacrolimus vs. Mycophenolate mofetil for Induction Therapy in Lupus Nephritis
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Ramathibodi Hospital
Nephritis, Lupus, Lupus Erythematosus, Systemic
A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment
The goal of this clinical trial is to learn if cenerimod, on top of regular treatment, works to treat active lupus nephritis in adults with systemic lupus erythematosus and active lupus nephritis.
- Trial name
- LUMIOS (NCT07201129)
- Testing
- Cenerimod
- Where
- 14 sites in United States
- Volunteers
- 300 people
- Sponsor
- Viatris Innovation GmbH
Systemic Lupus Erythematosus, Lupus Nephritis
Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune system dysregulation and inflammation affecting multiple organs.
- Trial name
- NCT07805863
- Volunteers
- 90 people
- Sponsor
- Assiut University
Systemic Lupus Erythematosus
CHABLIS-SC2: A Study of the Efficacy and Safety of Subcutaneous Blisibimod in Subjects With Systemic Lupus Erythematosus With or Without Nephritis
The purpose of this study is to evaluate the clinical efficacy of blisibimod as measured by a composite responder index in subjects who, despite corticosteroid use, continue to have autoantibody positive, clinically-active…
- Trial name
- NCT02074020
- Testing
- Blisibimod
- Sponsor
- Anthera Pharmaceuticals
SLE
Association of Serum Interleukin-33 Levels With Clinical Manifestations in Systemic Lupus Erythematosus
This is a case-control study investigating serum IL-33 levels and their association with clinical manifestations in systemic lupus erythematosus (SLE).
- Trial name
- NCT07149402
- Volunteers
- 150 people
- Sponsor
- Assiut University
Lupus Nephritis (LN)
The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients
To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
- Trial name
- NCT07823556
- Testing
- renal biopsy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Glomerulonephritis, Membranoproliferative, Lupus Nephritis
BG9588 (Anti-CD40L Antibody) to Treat Lupus Nephritis
The purpose of this study is to investigate whether the experimental drug BG9588 can be used to treat lupus nephritis more effectively and with less toxicity than standard treatments, including cyclophosphamide (Cytoxan)…
- Trial name
- NCT00001789
- Testing
- BG9588
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Lupus Nephritis
Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of Proliferative Forms of Lupus Glomerulopathy: Synergy Trial
This is a Phase IV, open-label, randomized trial to determine whether the combination of Belimumab (BEL) and Voclosporin (VCS), plus background therapy with Mycophenolate Mofetil (MMF), improves the proportion of patients with…
- Trial name
- SYNERGY (NCT07225387)
- Testing
- Voclosporin
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- NephroNet, Inc.
Lupus Nephritis
Efficacy and Safety of Tamibarotene(AM80) for Lupus Nephritis
An open-label study to evaluate the efficacy and safety of orally administered Tamibarotene to patients of Lupus Nephritis
- Trial name
- NCT01226147
- Testing
- Tamibarotene
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Kinki University
Lupus Nephritis
Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Introduction and background : Glomerulonephritis and auto-immune diseases are often associated. Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which have a severe impact on…
- Trial name
- GOODLUPUS (NCT03664908)
- Testing
- Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Systemic Lupus Erythematosus, Lupus Nephritis
Therapeutic Drug Monitoring of Mycophenolate Mofetil in Lupus Nephritis
Systemic lupus erythematosus (SLE) is an inflammatory, chronic, and multisystem autoimmune disease characterized by periods of activity and remission.
- Conditions
- Systemic Lupus Erythematosus, Lupus Nephritis, Drug Monitoring, Mycophenolic Acid
- Trial name
- LUPUS-MONITOR (NCT07493655)
- Testing
- Therapeutic Drug Monitoring, Standard clinical care
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Maranhao
Lupus Nephritis, Lupus Erythematosus, Systemic
Searching for Diagnostic/Prognostic Biomarkers in SLE With Renal Involvement by Proteomic Techniques
Objective: To search for potential biomarkers obtained by non-invasive methods (24-hour urine collection) that distinguish between patients diagnosed with systemic lupus erythematosus with or without renal involvement, patients…
- Trial name
- SLE (NCT03687138)
- Testing
- 24h urin sample
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Natalia A. Rivera García
Lupus Nephritis
the Association Between Metabolic Syndrome and Its Components With Lupus Nephritis in Systemic Lupus Erythematosus Patients
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that involve s many different organs and display a variable clinical course.
- Trial name
- NCT05964751
- Testing
- lipid profile, fasting blood suger
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Systemic Lupus Erythematosus
Cyclophosphamide in Lupus Nephritis
Cyclophosphamide is widely used in the treatment of cancer and autoimmune diseases such as lupus nephritis. However, there is considerable variability in the response to cyclophosphamide treatment.
- Trial name
- NCT00441220
- Where
- 3 sites in New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Lupus Nephritis
Urinary T Cell Biomarker for Prediction in Lupus Nephritis
Urinary T-lymphocytes may be predictive for clinical outcome in patients with lupus nephritis. The investigators hypothesize that the amount of CD4+ effector/memory T-cells in urine at time of diagnosis predicts the outcome of…
- Trial name
- NCT04320797
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
Lupus Nephritis
Long-Term Study of Multi-target Therapy as Maintenance Treatment for Lupus Nephritis
An multi-site, randomized, prospective study to compare the efficacy and safety of multi-target therapy as continuous induction and maintenance treatment versus CTX- Aza therapy.
- Trial name
- NCT01056237
- Testing
- Multi-target therapy, Azathioprine
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Zhi-Hong Liu, M.D.