Clinical trials: SPECT
Depression
Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression
This study will examine changes in brain dopamine transporter activity before and after antidepressant therapy.
- Trial name
- NCT00655057
- Testing
- S-citalopram, Cognitive behavioral therapy (CBT), TRODAT-1 single photon emission computed tomographic (SPECT) imaging
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Known CAD, or Intermediate-high Pretest Likelihood for CAD
Study of Perfusion and Anatomy's Role in Coronary Artery (CAD)
Three main clinical outcomes will be assessed: 1. Post-test resource utilization as assessed by referral rate to catheterization within 90-days of the index study; 2.
- Trial name
- SPARC (NCT00321399)
- Where
- 41 sites in United States, Canada
- Volunteers
- 3,019 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Embolism, Ventilation Perfusion Mismatch
68Ga PET/CT Versus 99mTc SPECT/CT for Lung Perfusion and Ventilation Scintigraphy; a Technical and Practical Feasibility Study
Lung perfusion scintigraphy with 99mTc-MAA and ventilation scintigraphy with Technegas (V/Q SPECT/CT) has been the cornerstone for the detection of pulmonary embolisms (PE) for many decades.
- Trial name
- GaTcha (NCT06246838)
- Testing
- Ga-68 V/Q PET/CT
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Hyperthyroidism
Thyroid Uptake Quantification on a New Generation of Gamma Camera
The primary objective of this study is to evaluate the potential of a new large field CZT gamma camera to estimate the thyroid uptake (TU) on Single photon emission computed tomography (SPECT) and SPECT/CT images in comparison…
- Trial name
- QUANTHYC (NCT05049551)
- Where
- Monaco
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Princesse Grace
Coronary Artery Disease
Safety and Efficacy Study of PB127 Ultrasound Contrast Agent in Patients With Suspected Coronary Artery Disease
This trial is to compare PB127 echocardiography to other heart imaging studies.
- Trial name
- NCT00595244
- Testing
- PB127 for injectable suspension
- Where
- 15 sites in United States
- Volunteers
- 456 people
- Sponsor
- Point Biomedical
Thromboembolism
A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)
This is a multi-center, prospective, international, randomized (1:1), open-label study with two parallel groups. This phase III study is planned to investigate the efficacy and safety of dabigatran etexilate versus dose-adjusted…
- Trial name
- NCT02913326
- Testing
- Dabigatran etexilate, Warfarin
- Where
- 36 sites in France, Germany and 7 more
- Volunteers
- 120 people
- Sponsor
- Boehringer Ingelheim
Schizophrenia
SPECT Study With SB-773812 In Schizophrenic Patients
This study is being conducted in 2 groups of schizophrenic patients: in group 1 the relationship between the dopaminergic D2 receptor occupancy (D2 RO ) and serotoninergic 5HT2A receptor occupancy at stable plasma concentration…
- Trial name
- NCT00269035
- Testing
- SB773812, Risperidone
- Where
- 6 sites in Spain
- Volunteers
- 95 people
- Sponsor
- GlaxoSmithKline
Lung Cancer
Ventilation Heterogeneity Prior to Lung Resection
This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed…
- Trial name
- NCT04191174
- Testing
- Hyperpolarized 129Xe MRI, Technegas V SPECT, Sputum Induction
- Where
- Canada
- Volunteers
- 115 people
- Sponsor
- McMaster University
Coronary Artery Disease
Comparison of Cardiac Imaging Techniques for Diagnosing Coronary Artery Disease
A large number of cardiac catheterizations are performed each year, primarily to diagnose heart disease. However, a cardiac catheterization is an invasive procedure which is associated with serious complications such as heart…
- Trial name
- PACIFIC (NCT01521468)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Amsterdam UMC, location VUmc
Bone Metastases
Pilot Project: Fast Whole-body Spect Scanning to Improve the Detection of Bone Metastases in Patients With Diagnosed Cancer
The investigators propose to investigate the performance of the image reconstruction software with resolution recovery correction for bone SPECT studies.
- Trial name
- NCT00824213
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Pulmonary Hypertension
CTEPH DIAGNOSIS Europe - MRI
Phase III diagnostic trial to demonstrate that functional lung MRI can replace VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH where positive findings are verified with catheter pulmonary angiography (CPA), or…
- Trial name
- NCT02791282
- Testing
- Index test: functional dynamic contrast enhanced (DCE)-MRI
- Where
- Germany
- Volunteers
- 1,080 people
- Sponsor
- Hannover Medical School
Chest Pain
Prognosis of Very Low Dose SPECT
Nuclear stress testing evaluates whether the heart receives enough blood, by injection of a nuclear isotope during a stress on the heart that permits taking pictures of the heart muscle.
- Trial name
- NCT01387152
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Coronary Artery Disease
Assessment of Patients With Suspected Coronary Artery Disease (CAD): What is the Best Initial Imaging Strategy?
Patients who present with chest pain are investigated with tests designed to confirm or exclude the presence of Coronary Artery Disease (CAD), as well as determine risk of poor outcome.
- Trial name
- IMAGE-CAD (NCT01668290)
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Harald Becher
Breast Cancer
99mTc-ABH2 SPECT/CT in Breast Cancer
This prospective study will investigate the potential usefulness of 99mTc-ABH2 SPECT/CT in the diagnostic performance and evaluation efficacy of breast cancer.
- Trial name
- NCT06194565
- Testing
- 99mTc-ABH2
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Glioblastoma Multiforme (GBM), Pancreatic Ductal Adenocarcinoma (PDAC)
Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)
The goal of this Phase I clinical trial is to evaluate how the imaging drug 203Pb- RMX-VH-PIB distributes in the body and how much radiation different organs receive in patients with glioblastoma multiforme (GBM) or pancreatic…
- Trial name
- RMX-VH (NCT07733674)
- Testing
- 203Pb-RMX-VHPIB injection, SPECT/CT Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Radiomedix, Inc.
Pancreatic Cancer, Breast Cancer
The Clinical Application Value of SPECT Imaging Targeting LRRC15 in Malignant Tumors
Here's a polished version of the text: "This project involves patients with high-expression LRRC15 malignant tumors who are either clinically suspected of or diagnosed with pancreatic cancer, breast cancer, lung cancer, ovarian…
- Conditions
- Pancreatic Cancer, Breast Cancer, Lung Cancer, Sarcoma
- Trial name
- NCT07651020
- Testing
- Specific SPECT imaging agents targeting LRRC15
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Myocardial Ischemia
The Comparison of the Necessity of Repeat Myocardial Perfusion SPECT Studies Between Tc-99m Tetro and Tc-99m Mibi
Research Questions: 1. Is there a significant difference between the causal repeat rate of myocardial perfusion studies for Tc99m tetrofosmin and Tc99m sestamibi? 2.
- Trial name
- NCT01047150
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Cardiac Imaging of Augusta
Breast Cancer
Integrin α6-targeted SPECT Imaging of Breast Cancer
A novel radiotracer 99mTc-RWY targeting Integrin α6 was developed, and the pilot first-in-human study for SPECT imaging of breast cancer was performed in seven healthy volunteers and two breast cancer patients to assess the…
- Trial name
- NCT04289532
- Testing
- 99mTc-RWY
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Peking University
Hyperparathyroidism
NUclear MEdicine DIagnostic and Artificial Intelligence
Artificial intelligence algorithms for parathyroid adenoma detection in parathyroid scans The aim of the study is to develop programs for the automatic subtraction of planar and tomographic parathyroid images and for the…
- Trial name
- NUMEDIA (NCT05963841)
- Testing
- treatment program
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiac Disease
Attenuation Corrected Cardiac SPECT Using the GE Hawkeye Camera System
The accuracy of stress single photon emission computed tomography (SPECT) is limited by imaging artifacts, many of which are caused by soft tissue attenuation.
- Trial name
- Hawkeye (NCT00587730)
- Testing
- GE Attenuation Corrected Hawkeye Camera
- Where
- United States
- Volunteers
- 608 people
- Sponsor
- Mayo Clinic