Clinical trials: SPECT-CT
Breast Cancer, Lymphedema
Single-Photon Emission Computed Tomography, Computed Tomography Lymphoscintigraphy, and Intensity-Modulated Radiation Therapy in Treating Patients Who Have Undergone Surgery for Stage I or Stage II Breast Cancer
RATIONALE: Diagnostic procedures, such as single-photon emission computed tomography and computed tomography lymphoscintigraphy, may help lower the dose of radiation therapy after surgery, and help prevent lymphedema.
- Trial name
- NCT00743314
- Testing
- screening questionnaire administration, computed tomography, lymphoscintigraphy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Cervical Cancer, Breast Cancer
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or…
- Conditions
- Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
- Trial name
- NCT05283330
- Testing
- ²¹²Pb-DOTAM-GRPR1
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Orano Med Theranostics, SAS
Non Small Cell Lung Cancer
Phase 2 Study Comparing 99mTc-EC-DG SPECT/CT With 18F FDG PET/CT in Patients With Non-small Cell Lung Cancer (NSCLC)
This is a multiple-center Phase 2 study designed to expand the patient safety and clinical information using 99m Tc-Ec-DG with Spect/CT imaging, to develop procedures and methods for evaluation of the imaging studies, to…
- Trial name
- NCT00865319
- Testing
- Radiolabeled (99Tc) EC-DG (ethylenedicysteine-deoxyglucose), 18 F fluorodeoxyglucose
- Where
- 6 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Cell>Point LLC
Bone Metastases
Evaluation of an Accelerated Body-whole Bone CT Procedure With the CZT(Cadmium-Zinc-Telluride) "VERITON-CT ™" Camera
The purpose of the OSS study is to evaluate a procedure involving a single full body SPECT/CT (Single photon emission computed tomography coupled with a computerized tomography) 3D recording with a new semiconductor camera,his…
- Trial name
- OSS (NCT04157166)
- Testing
- Group 1 to record a 25 minutes whole body 3D in camera VERITON-CT ™ after scintigraphy + SPECT/CT in camera d'Anger
- Where
- 2 sites in France
- Volunteers
- 146 people
- Sponsor
- Central Hospital, Nancy, France
COPD
Assessment of Lung Perfusion in Patients With Chronic Obstructive Pulmonary Disease Using FD MRI
In the recent years a novel method for functional lung imaging called Fourier decomposition MRI (FD MRI) has been introduced that allows for simultaneous assessment of regional lung perfusion and ventilation-related information…
- Trial name
- FD-COPD (NCT02367209)
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University Hospital, Basel, Switzerland
Thyroid Gland Follicular Carcinoma
Radioiodine Planar and a SPECT/CT Imaging With Iodine-123 for Evaluation of Follicular Thyroid Nodules Prior to Surgery
This study evaluates radioiodine planar and SPECT/CT imaging with iodine-123 in patients with follicular thyroid nodules prior to surgery.
- Trial name
- NCT05591092
- Testing
- Computed Tomography, Iodine I-123, Planar Imaging
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Prostate Cancer
Study to Evaluate 99mTc-MIP-1404 SPECT/CT Imaging in Men With Biopsy Proven Low-Grade Prostate Cancer
99mTc-MIP-1404 is a radioactive diagnostic imaging agent indicated for imaging men with newly diagnosed prostate cancer whose biopsy indicates a histopathologic Gleason Score of ≤ 3+4 severity who are candidates for active…
- Trial name
- proSPECT-AS (NCT02615067)
- Testing
- 99mTc-MIP-1404 Injection, Whole-Body Planar and pelvic SPECT/CT scan
- Where
- 45 sites in United States, Canada
- Volunteers
- 531 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Rheumatoid Arthritis (RA)
Research on the Application of 99mTc-TCR-FAPI SPECT Imaging in Rheumatoid Arthritis
This study proposes to evaluate 99mTc-CTR-FAPI SPECT imaging as a cost-effective, low-radiation, and widely accessible alternative to 68Ga-FAPI PET/CT for assessing synovial lesions in RA patients, aiming to validate its…
- Trial name
- NCT07138729
- Testing
- 68Ga-FAPI PET/CT and 99mTc-CTR-FAPI SPECT
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Luo Yaping
Cervical Cancer, Vulvar Cancer
Added-value of SPECT/CT in Patients Undergoing LM/SL for Gynecological Cancers
Nodal staging is a key-step in pre-treatment assessment of gynecological cancers. In recent years, lymphatic mapping and sentinel lymphadenectomy (LM/SL) as a minimally invasive pelvic lymph nodes staging has been successfully…
- Trial name
- NCT00773071
- Testing
- SPECT/CT guided LM/SL
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kaposi's Sarcoma
Evaluation of Tc 99m Tilmanocept Localization in Primary Cutaneous Kaposi's Sarcoma and Lymphatic Drainage by SPECT/CT
The purpose of this study (NAV3-12) is to determine the dissemination and localization of Tc 99m tilmanocept by SPECT and SPECT/CT imaging in subjects with confirmed cutaneous KS.
- Trial name
- NCT02201420
- Testing
- Tc 99m tilmanocept
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Navidea Biopharmaceuticals
Degenerative Disc Disease, Back Pain Lower Back Chronic
The SPINUS II Study: Spinal Fusion for Multilevel SPECT/CT Positive Lumbar Degeneration
The aim of the present study is to find out whether fusion of multilevel SPECT/CT positive lumbar degeneration leads to a significant improvement of pain and disability.
- Conditions
- Degenerative Disc Disease, Back Pain Lower Back Chronic, Facet Joint Arthropathy, Facet Syndrome of Lumbar Spine
- Trial name
- NCT04893720
- Testing
- Lumbar fusion
- Where
- 2 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- Military University Hospital, Prague
Human Immunodeficiency Virus
123I Radiolabeled 3BNC117
The conventional way to control HIV infection is the usage of a drug cocktail capable of suppressing the viral replication cycle, commonly known as antiretroviral therapy (ART).
- Trial name
- NCT03468582
- Testing
- 123I radiolabeled 3BNC117
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Lausanne Hospitals
Primary Breast Cancer
Molecular Imaging of EpCam Expression in Breast Cancer Using [99mTc]Tc-DARPinEc1-G3C
The study should evaluate distribution of [99mTc]Tc-DARPinEc1-G3C in patients with primary Triple negative and Luminal breast cancer. The primary objective are: 1.
- Trial name
- EpCam-Scan (NCT07784660)
- Testing
- [99mTc]Tc-DARPinEc1-G3C
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Neuroendocrine Tumor Grade 2, Neuroendocrine Tumor Grade 1
A First-in-human Clinical Trial to Evaluate an Alpha-radiation Imaging Agent
This is a first in man study to determine if [203Pb]VMT-α-NET identifies neuroendocrine tumors with SPECT/CT. This is the first step to testing [212Pb]-based alpha radiation therapy in neuroendocrine therapy.
- Trial name
- NCT05111509
- Testing
- [203Pb]VMT-α-NET, SPECT/CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yusuf Menda
Neuroendocrine Tumors, Hyperthyroidism
Optimising Molecular Radionuclide Therapy
This project will examine the role of the whole body, PET and SPECT imaging before, during and after radionuclide treatment for 177Lu-Dotatate therapy, whole body and SPECT imaging for 131-I for thyroid cancer therapy, and…
- Conditions
- Neuroendocrine Tumors, Hyperthyroidism, Thyroid Cancer, Thyroid Carcinoma
- Trial name
- SELFIE (NCT04922801)
- Testing
- Nuclear Medicine whole-body, SPECT/CT imaging., PET/CT imaging.
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Dementia
SPECT/CT in the Diagnosis of Dementia
Aim of the study is to evaluate whether Tc-99m-ECD-SPECT/CT enhances early diagnosis of dementia in two specific patient groups: (1) patient with mild cognitive impairment, and (2) patient with possible symptoms and signs of…
- Trial name
- DEMSPET (NCT01112501)
- Where
- Finland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Parathyroid Adenoma
99mTc Sestamibi SPECT/CT vs 18F Fluorocholine PET/CT
This study proposes the use of a well-established PET isotope, Fluorine-18 (18F), bound to Choline, for a prospective single-center, single-arm study for participants with suspected parathyroid adenoma and negative or equivocal…
- Trial name
- 18FCH (NCT05891769)
- Testing
- 18Fluorocholine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Andrei Iagaru
Lung Carcinoma, Malignant Neoplasm
SPECT/CT in Measuring Lung Function in Patients With Cancer Undergoing Radiation Therapy
This pilot clinical trial studies single photon emission computed tomography (SPECT)/computed tomography (CT) in measuring lung function in patients with cancer undergoing radiation therapy.
- Trial name
- NCT01982123
- Testing
- SPECT/CT, Single Photon Emission Computed Tomography, Technetium Tc-99m Albumin Aggregated
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
HIV
Application of IV 99mTc-tilmanocept for Imaging of Macrophage-specific Inflammation
The purpose of this study is to evaluate uptake of intravenously administered 99mTc-tilmanocept using single photon emission computed tomography (SPECT/CT) scanning in individuals with HIV and individuals without HIV.
- Trial name
- NCT03523130
- Testing
- Imaging
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiac Amyloidosis
Fast Cardiac Bone SPECT-CZT in Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis (ATTR-CA) is traditionally diagnosed using planar bone scintigraphy with a Perugini visual score ≥ 2.
- Trial name
- PeakAmyL (NCT07605741)
- Testing
- bone scintigraphy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France