Clinical trials: ST Segment Elevation Acute Myocardial Infarction
Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction
An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is manifested in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world.
- Conditions
- Acute Coronary Syndrome, Non-ST Elevation (NSTEMI) Myocardial Infarction, Acute ST Segment Elevation Myocardial Infarction, Angina, Unstable
- Trial name
- DETO2X-AMI (NCT01787110)
- Testing
- Oxygen
- Where
- 34 sites in Sweden
- Volunteers
- 6,629 people
- Sponsor
- Karolinska Institutet
Ischemic Heart Disease, Myocardial Infarction
Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study
RITA-MI aims to develop of a novel therapeutic concept to target the immune response in patients with acute myocardial infarction (MI) by depleting B-cells with a single injection of Rituximab which is approved for clinical use…
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Inflammation
- Trial name
- RITA-MI (NCT03072199)
- Testing
- RiTUXimab Injection
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Myocardial Infarction
A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study
This study is a prospective, randomized controlled, single blind, two-arm, multi center clinical evaluation. A total of 1500 patients will be enrolled in the study.
- Trial name
- NCT00828087
- Testing
- Everolimus Eluting Coronary Stent System, cobalt chromium balloon expandable stent ( non drug eluting stent Arm)
- Where
- 11 sites in Italy, Netherlands and 1 more
- Volunteers
- 1,504 people
- Sponsor
- Spanish Society of Cardiology
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Angina Pectoris, Unstable Angina
Pilot Study of Hemoglobin Based Oxygen Therapeutics in Elective Coronary Revascularization
The purpose of this study is to assess the safety and feasibility of a novel oxygen carrying solution, HBOC-201, in the setting of PCI for Acute Coronary Syndromes from randomization til hospital discharge.
- Conditions
- Angina Pectoris, Unstable Angina, Myocardial Infarction
- Trial name
- NCT00317512
- Testing
- Percutaneous Coronary Revascularization, Hemoglobin-Based Oxygen Carrier-201 (HBOC-201), Voluven
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 45 people
- Sponsor
- Biopure Corporation
STEMI, Multi Vessel Coronary Artery Disease
STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）
An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with STEMI and MVD Objectives: The present study aimed to investigate the difference in major adverse cardiac event…
- Conditions
- STEMI, Multi Vessel Coronary Artery Disease, Percutaneous Coronary Intervention, AMI Patients With Multivessel Disease, Staged PCI
- Trial name
- SAGED (NCT04918030)
- Testing
- Early staged PCI, Late staged PCI
- Where
- China
- Volunteers
- 1,586 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
Acute Coronary Syndrome, Coronary Artery Disease
Full-dose Atorvastatin After Acute Coronary Syndrome (ACS) in Non-revascularisable Coronary Artery Disease
This study was designed to test the hypothesis that the addition of full-dose atorvastatin (80 mg/day) to conventional medical treatment could reduce ischaemic recurrences after non-ST-elevation acute myocardial infarction…
- Trial name
- APRIRE (NCT01187992)
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- San Filippo Neri General Hospital
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Israel Satellite Registry
BIOTRONIK - SaFety and Performance Registry for a diabetic patient population with the .bimus Eluting Orsiro Stent System Within daily clinical practice - III
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Diabetes Mellitus Type 1 or 2
- Trial name
- NCT01895712
- Where
- 6 sites in Israel
- Volunteers
- 120 people
- Sponsor
- BIOTRONIK Israel
Acute Coronary Syndromes, Non ST Elevation Myocardial Infarction
Sub Lingual Versus Traditional Oral Administration of Ticagrelor in Acute Coronary Syndrome/Non ST-elevation Myocardial Infarction - A Platelet Reactivity Study
Our goal is to examine sub lingual versus traditional oral administration of ticagrelor in ACS/non ST-elevation Myocardial Infarction (NSTEMI) patients on platelet reactivity.
- Trial name
- NCT02402400
- Testing
- Sub Lingual Ticagrelor
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
HELicobacter Pylori Screening in Patients With Acute Myocardial Infarction Pilot Study
The aim of this study is to determine the prevalence of Helicobacter pylori (Hp) infection in patients with myocardial infarction (MI).
- Trial name
- HELPpilot (NCT04289012)
- Testing
- Helicobacter Pylori screening by UBT
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Karolinska Institutet
Myocardial Infarction, Acute, ST Segment Elevation Myocardial Infarction
A Trial on the Role of Community Pharmacist in Improving Adherence and Clinical Outcomes in Post-Infarction
The purpose of this pilot study is to evaluate the effectiveness of the active involvement of Community Pharmacists in improving adherence to medical prescriptions in patients with acute myocardial infarction (AMI), reducing the…
- Conditions
- Myocardial Infarction, Acute, ST Segment Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI)
- Trial name
- IM-ADHERENCE (NCT03621111)
- Testing
- Patient-counseling, Patient self-administered questionnaire, Pills counts
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda ULSS 5 Polesana
ST Elevation Myocardial Infarction
Evaluate the Efficacy and Safety of Allogeneic Umbilical Cord Mesenchymal Stem Cells as an Add-On Treatment for Acute ST-elevation Myocardial Infarction (STEMI) Patients
This phase IIa study is to identify the efficacy and safety of IC(intracoronary) and IV(Intravenous) administrations of UMSC01 in patients with STEMI .
- Trial name
- NCT06147986
- Testing
- Allogeneic umbilical cord mesenchymal stem cells, Control group
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome
inflAmmatory maRkers in Blood and Thrombus Aspirated From Patients With acutE myocaRdial Infarction With St-segment elevAtion
The prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory…
- Trial name
- ARTERIA (NCT01757886)
- Testing
- Biomarkers to analyze both intracoronary thrombi as blood
- Where
- 3 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Fundación Canaria Rafael Clavijo para la Investigación Biomédica
ST-Segment Elevation Myocardial Infarction
Ezetimibe In Addition To Atorvastatin Therapy On The Plaque Composition In Patients With Acute Myocardial Infarction.
The purpose of the study is to examine the effect of the cholesterol lowering agent Ezetimibe when used in addition to optimal treatment with Atorvastatin in patients with acute ST-Elevation Myocardial Infarction (STEMI) who have…
- Trial name
- OCTIVUS (NCT01385631)
- Testing
- Ezetimibe
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Myocardial Infarction, Percutaneous Coronary Intervention
China-Administration of Nicorandil Group（CHANGE）
We compared the infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) treated by nicorandil before and after the reperfusion with those standard…
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Nicorandil
- Trial name
- NCT03445728
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Chinese PLA General Hospital
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
IVUS Versus FFR for Non-infarct Related Artery Lesions in Patients With Multivessel Disease and Acute MI
The aim of the study is to compare clinical outcomes between intravascular ultrasound (IVUS)-guided treatment decision versus fractional flow reserve (FFR)-guided treatment decision for non-infarct related artery stenosis in…
- Trial name
- FRAME-AMI2 (NCT05812963)
- Testing
- IVUS-guided PCI group, FFR-guided PCI group
- Where
- 2 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN studIeS for TreatMent of Acute Myocardial InfarctionTreatment of ST-elevation Acute Myocardial Infarction
To treat patients with acute myocardial infarction, primary percutaneous coronary intervention (PCI) will be performed with the use of an everolimus-eluting cobalt- chromium stent (everolimus-eluting stent: EES, Xience Prime…
- Trial name
- MECHANISM-AMI (NCT02014753)
- Testing
- cobalt-chromium everolimus-eluting stent (CoCr-EES)
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Iwate Medical University
Myocardial Infarction
Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction
The primary objectives of the trial are: 1. To establish the safety and efficacy of the use of bivalirudin (+ bail-out GP IIb/IIIa inhibitors) compared to the use of unfractionated heparin + GP IIb/IIIa inhibitors in patients…
- Trial name
- NCT00433966
- Testing
- Bivalirudin, Unfractionated heparin, Bare metal stent
- Where
- United States
- Volunteers
- 3,602 people
- Sponsor
- Cardiovascular Research Foundation, New York
Acute Myocardial Infarction
Minimizing Reperfusion Injury in Patients With Acute Myocardial Infarction
The size of a heart attack will be decreased by the use of timed balloon inflations to open the blocked blood vessel.
- Trial name
- PCinAMI (NCT00846378)
- Testing
- Post conditioning, Usual Care for STEMI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati