Clinical trials: ST Segment Elevation Myocardial Infarction (STEMI)
ST-elevation Myocardial Infarction
Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
Heart attacks, or myocardial infarcts, are a major cause of death and disability in the UK. Immediate unblocking of the obstructed heart vessel with a balloon catheter and implantation of a mesh scaffold (stent) in heart centers…
- Trial name
- MINIMISE-STEMI (NCT01882179)
- Testing
- Mineralocorticoid receptor antagonist potassium-canrenoate
- Where
- 4 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
NSTEMI - Non-ST Segment Elevation MI
Clinical and Economic Outcomes of High Sensitivity Troponin for no ST Elevation Myocardial Infarction in Patients With Chest Pain in Emergency Departments in Italy-An Observational Study
Myocardial infarction is one of the leading causes of death and disability worldwide. In addition to standard diagnostic methods, it has been shown that high-sensitivity cardiac troponin assays allow greater sensitivity in the…
- Trial name
- NCT03489603
- Where
- Italy
- Volunteers
- 2,913 people
- Sponsor
- Marco Marchetti
Myocardial Infarction, Acute
Korea Acute Myocardial Infarction Registry
This multicentre observational registry study, the Korea Acute Myocardial Infarction Registry (KAMIR-7), aims to improve long-term prognosis in Korean patients with acute myocardial infarction (AMI) by establishing and operating…
- Trial name
- KAMIR-7 (NCT07409441)
- Where
- 2 sites in South Korea
- Volunteers
- 20,000 people
- Sponsor
- Samsung Medical Center
Non-ST Elevation Myocardial Infarction (NSTEMI)
Prevention of Acute Kidney Injury in Patients With NSTEMI
A randomized, double-blind, placebo-controlled, multi-center, phase 2 clinical study in patients with NSTEMI undergoing urgent coronary angiography.
- Trial name
- AKI (NCT04912141)
- Where
- 4 sites in Switzerland
- Volunteers
- 29 people
- Sponsor
- Pharming Technologies B.V.
ST Elevation Myocardial Infarction
TIMES: Ticagrelor vs. Placebo/ Clopidogrel With Aspirin in Anterior STEMI Patients Treated With Primary PCI
This is a single-centred, double blind randomized controlled trial comparing ticagrelor with placebo in clopidogrel and aspirin loaded patients.
- Trial name
- NCT03145194
- Testing
- Ticagrelor
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Myocardial Infarction, STEMI
Femoral Versus Radial Access for Primary PCI
Primary percutaneous coronary intervention (PPCI) has become the dominant strategy for the treatment of ST-elevation myocardial infarction (STEMI), as studies have shown that PPCI is superior to fibrinolytic therapy.
- Trial name
- SAFARI-STEMI (NCT01398254)
- Testing
- Primary Percutaneous Coronary Intervention (PPCI)
- Where
- 5 sites in Canada
- Volunteers
- 2,292 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease, Intestinal Disease
The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease.
Define a signature of gut microbiota composition and related metabolites in patients with ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic coronary disease (CAD).
- Trial name
- GUT-ACS (NCT04605627)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction
French Registry of Acute ST-elevation or Non-ST-elevation Myocardial Infarction 2015
Over the last two decades, considerable progress has been made in the management of myocardial infarction, both in the acute phase and in monitoring beyond the hospital phase.
- Trial name
- FASTMI2015 (NCT02566200)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- French Cardiology Society
Percutaneous Coronary Intervention, No-reflow Phenomen
The RESTORE-SIRIO Randomized Controlled Trial
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy for treating acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- Percutaneous Coronary Intervention, No-reflow Phenomen, Acute ST-segment Elevation Myocardial Infarction
- Trial name
- RESTORE-SIRIO (NCT02405130)
- Testing
- intracoronary epinephrine, no intracoronary epinephrine
- Where
- Germany
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Attack, Cardiac Event
Mobile Advanced Multi-Parameter Reporting in Patients Wearing a Novel Device: Utilization During Cardiac Rehabilitation
Advanced remote multi-parameter reporting during cardiac rehabilitation (MAPS-III). The primary purpose of this observational study is to collect baseline information of cardiac rehabilitation usage in the US for post-myocardial…
- Conditions
- Heart Attack, Cardiac Event, Cardiac Disease, Cardiac Infarct
- Trial name
- MAPS-III (NCT05957172)
- Testing
- ZOLL Arrhythmia Management System
- Sponsor
- Zoll Medical Corporation
Acute Non-ST Elevation Myocardial Infarction
DLBS1033 for Acute NSTEMI Without Early Coronary Revascularization
This is a prospective, randomized, double-blind, double-dummy, and controlled study of DLBS1033 in the management of acute non-ST elevation myocardial infarction (NSTEMI) without early coronary revascularization.
- Trial name
- NCT02146664
- Testing
- DLBS1033
- Where
- 2 sites in Indonesia
- Sponsor
- Dexa Medica Group
Left Ventricular Remodeling, Plasma Multi-Omics
Prediction of LVAR and MACE in STEMI Though Plasma Multiomics Analysis
To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to…
- Conditions
- Left Ventricular Remodeling, Plasma Multi-Omics, Acute ST-segment Elevation Myocardial Infarction, Immunomics
- Trial name
- NCT06885619
- Testing
- Diagnostic Test: echocardiography and blood collection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction
Effect of Doxycycline on Cardiac Remodelling in STEMI Patients
Subsequent to the loss of myocardium post-myocardial infarction (MI), the affected ventricle undergoes some dynamic structural and functional changes known as remodeling. Cardiac remodeling progresses into heart failure (HF).
- Conditions
- ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction, Heart Failure, Remodeling, Ventricular
- Trial name
- NCT03960411
- Testing
- Doxycycline 100Mg Capsule
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Felix Chikita Fredy, MD
Myocardial Infarction, Acute, Myocardial Strain
Assessment of the Effects of Long-term Lipid-lowering Therapy in Patients With Primary STEMI or NSTEMI
In a single-center, open-label, prospective, controlled, clinical study, it is planned to include 300 patients hospitalized in the cardiology department of SBHI Penza regional clinical hospital n.a. N.N. Burdenko.
- Conditions
- Myocardial Infarction, Acute, Myocardial Strain, Arterial Stiffness, Quality of Life
- Trial name
- CONTRAST-2 (NCT04347434)
- Testing
- Atorvastatin 80mg
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Penza State University
Primary PCI, ST-elevation Myocardial Infarction (STEMI)
Impact of Pre-Hospital Heparin Loading in STEMI Patients for Primary PCI: The HELP-PCI-2 Trial
This randomized, multicenter, prospective trial will enroll 6,294 participants in approximately 80 centers. STEMI patients with onset time within 12 hours and scheduled for primary PCI will be randomly assigned to two groups in a…
- Trial name
- HELP-PCI-2 (NCT07361783)
- Testing
- Unfractionated heparin treatment
- Where
- China
- Volunteers
- 6,294 people
- Sponsor
- Chen Jing
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes
AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study
This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- OCR-LLM-CHD (NCT07449429)
- Testing
- OCR-Prompt-LLM Information Extraction and Classification Workflow (OCR-Prompt-LLM), Manual Clinical Data Review
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Disease, Coronary Artery Disease
MGuard Stent and Microcirculation
NSTE-ACS represents the most frequent indication for coronary angiography and percutaneous coronary intervention (PCI) worldwide.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Atherosclerosis, Cardiovascular Diseases
- Trial name
- GUARDIANCORY (NCT03087175)
- Testing
- MGuard stent, Drug eluting stent and bare metal stent
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble
STEMI
OCT Guided Magmaris RMS in STEMI
Percutaneous treatment of coronary artery disease depends on the implantation of stents within diseased coronary segments. Compared with conventional bare-metal and drug- eluting stents, which remain permanently within the…
- Trial name
- BESTMAG (NCT03955731)
- Testing
- Magmaris resorbable magnesium scaffold
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stable Angina, Unstable Angina, NSTEMI
Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease
This retrospective study will evaluate the coronary angiograms of approximately 100 patients who have undergone invasive angiography and fractional flow reserve (FFR).
- Trial name
- NCT06183294
- Testing
- Collecting invasive FFR measurements.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Myocardial Infarction, Anterior Wall
COmprehensive Remote Ischemic Conditioning in Myocardial Infarction
The primary objective of the CORIC-MI trial is to evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC) as an adjunctive therapy in patients with ST-elevation myocardial infarction (STEMI)…
- Trial name
- CORIC-MI (NCT03233919)
- Testing
- comprehensive remote ischaemic conditioning
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
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