Clinical trials: ST Segment Elevation Myocardial Infarction (STEMI)
Acute Myocardial Infarction
Study to Assess the Safety and Cardiovascular Effects of Autologous Adipose-Derived Stromal Cells Implantation In Patients During the Acute Recovery Phase of ST-Elevation Myocardial Infarction
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe? and 2) Is treatment effective in improving cardiac function and clinical outcomes?
- Trial name
- Acute MI (NCT01974128)
- Testing
- ASC isolation and implantation
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
ST Segment Elevation Myocardial Infarction
Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction
The primary objective of this study is to determine if the Smartphone electrocardiogram (ECG) is an acceptable replacement for a standard ECG in the identification of ST Elevation Myocardial Infarction (STEMI).
- Trial name
- ST LEUIS (NCT02498405)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Intermountain Health Care, Inc.
Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention
Non-culprit Vessels for ST-Segment Elevation Myocardial Infarction
To compare the different effect of conservative pharmacotherapy and Staged Percutaneous Coronary Intervention (SPCI) on significant non-culprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) at…
- Conditions
- Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention, Non-culprit Vessels, ST-Segment Elevation Myocardial Infarction
- Trial name
- CPVsSPCI (NCT02154919)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
CD-NP (Cenderitide) Therapy for the Preservation of Left Ventricular Function
The primary endpoint is to assess the safety and tolerability of Cenderitide (CD-NP) with the incidence of symptomatic hypotension being one of the key safety variables.
- Trial name
- BELIEVE III (NCT02071602)
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Coronary Disease, Myocardial Infarction
ASSessing the Effect of Anti-IL-6 Treatment in Myocardial Infarction: The ASSAIL-MI Trial
The main goal of this study is to evaluate the ability of a single administration of tocilizumab to reduce myocardial damage in patients presenting with an acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- ASSAIL-MI (NCT03004703)
- Testing
- Tocilizumab, Sodium chloride 0.9%
- Where
- 3 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction
Safety and Efficacy Study of MGuard Stent After a Heart Attack
The goal of this study is to demonstrate the superiority of the MGuard™ stent over commercially-approved bare-metal (BMS) /drug-eluting stents (DES) in achieving better myocardial reperfusion in primary angioplasty for the…
- Trial name
- MASTER (NCT01368471)
- Testing
- MGuard, Control BMS or DES
- Where
- 7 sites in Poland, South Africa
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- InspireMD
Acute Myocardial Infarction
Tirofiban Intracoronary Bolus-only Versus Intravenous Bolus Plus Infusion in STEMI Patients
The aim of this randomized trial is to compare the efficacy of high dose tirofiban administered as either an intracoronary bolus alone or as an intravenous bolus followed by a maintenance infusion with respect to microvascular…
- Trial name
- NCT01109134
- Testing
- tirofiban intracoronary bolus-only, tirofiban intravenous bolus plus infusion
- Volunteers
- 49 people
- Sponsor
- Kosuyolu Heart Hospital
Myocardial Reperfusion, STEMI - ST Elevation Myocardial Infarction
Impact of Injection Pressure on Myocardial Reperfusion During Primary PCI
Percutaneous coronary intervention for myocardial infarction with ST elevation could be complicated with thrombus embolisation to the more distal segments of the culprit artery.
- Trial name
- ImPress (NCT03445364)
- Testing
- Use of different injection pressure during primary PCI
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Sestre Milosrdnice
Acute Myocardial Infarction With ST Elevation, Intelligent Management Platform
Artificial Intelligence System for Early Warning of Adverse Events in Acute Myocardial Infarction
The goal of this observational study is to learn about the effectiveness of an artificial intelligence-based early warning system for predicting adverse events in patients with acute myocardial infarction (AMI).
- Conditions
- Acute Myocardial Infarction With ST Elevation, Intelligent Management Platform, Early Warning
- Trial name
- AIEWAEAMI (NCT07139860)
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Hui Chen
Myocardial Infarction, Cardiovascular Disease
Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI
OBJECTIVE OF THE STUDY: To test the hypothesis that 6 months DAPT (Dual anti-platelet therapy) after second generation DES (Drug Eluting Stent) implantation in STEMI (ST elevation Myocardial Infarction) is not inferior to 12…
- Trial name
- DAPT-STEMI (NCT01459627)
- Testing
- 6 months DAPT, 12 months DAPT
- Where
- 16 sites in Netherlands, Norway and 2 more
- Volunteers
- 1,100 people
- Sponsor
- Maasstad Hospital
STEMI
Door To Unloading With IMPELLA CP System in Acute Myocardial Infarction - Safety and Feasibility Study
Direct active unloading of the left ventricle with the Impella CP System prior to PPCI in patients with ST-elevation myocardial infarction (STEMI) is safe and feasible
- Trial name
- DTU (NCT03000270)
- Testing
- Impella unloading prior to PPCI
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- Abiomed Inc.
ST-segment Elevation Myocardial Infarction
Henan STEMI Registry
ST-segment elevation myocardial infarction (STEMI) remains among the most acute and critical diseases, with primary percutaneous coronary intervention (pPCI) and thrombolysis as mainstay reperfusion treatments.
- Trial name
- NCT02641262
- Where
- China
- Volunteers
- 5,479 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
The aim of the prospective observational DISTEMI-Study in people with and without Diabetes mellitus (DI) after new onset of ST-Segment Elevation Myocardial Infarction (STEMI) aged 18-80 years at inclusion into the study is to…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- DISTEMI (NCT05046483)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction
Effect of Doxycycline on Cardiac Remodelling in STEMI Patients
Subsequent to the loss of myocardium post-myocardial infarction (MI), the affected ventricle undergoes some dynamic structural and functional changes known as remodeling. Cardiac remodeling progresses into heart failure (HF).
- Conditions
- ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction, Heart Failure, Remodeling, Ventricular
- Trial name
- NCT03960411
- Testing
- Doxycycline 100Mg Capsule
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Felix Chikita Fredy, MD
STEMI, Multi Vessel Coronary Artery Disease
STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）
An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with STEMI and MVD Objectives: The present study aimed to investigate the difference in major adverse cardiac event…
- Conditions
- STEMI, Multi Vessel Coronary Artery Disease, Percutaneous Coronary Intervention, AMI Patients With Multivessel Disease, Staged PCI
- Trial name
- SAGED (NCT04918030)
- Testing
- Early staged PCI, Late staged PCI
- Where
- China
- Volunteers
- 1,586 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
Myocardial Infarction
Comparison of Ticagrelor Pharmacokinetics and Pharmacodynamics in STEMI and NSTEMI Patients
The purpose of the PINPOINT study is to compare pharmacokinetics (PK) and pharmacodynamics (PD) of ticagrelor in ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) patients designated…
- Trial name
- PINPOINT (NCT02602444)
- Testing
- ticagrelor
- Where
- Poland
- Volunteers
- 73 people
- Sponsor
- Collegium Medicum w Bydgoszczy
ST-Elevation Myocardial Infarction
Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches
This study investigates the effect of Colchicine in preventing heart structure changes following ST-segment elevation myocardial infarction.
- Trial name
- NCT06426537
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Indonesia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Acute ST Segment Elevation Myocardial Infarction
Safety and Efficacy of Percutaneous Coronary Intervention Combined With Thrombolysis at Different Time
Patients with acute ST-segment elevation myocardial infarction and thrombolysis indications, will be given the recombinant human prourokinase for thrombolysis treatment, and in accordance with the guidelines, will be treated with…
- Trial name
- SEPCIT (NCT03137212)
- Testing
- thrombolysis and PCI of A type, thrombolysis and PCI of B type
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Hospital of Jilin University
Non ST Elevation Myocardial Infarction, Unstable Angina
Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients with Non ST Elevation Elevation Acute Coronary Syndrome
Background: Most coronary artery bypass grafts (CABG) are diseased or blocked within 10 years of surgery meaning CABG survivors have an ever increasing risk of recurrent angina, heart attack and death.
- Trial name
- CABG-ACS (NCT01895751)
- Testing
- Invasive management
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS National Waiting Times Centre Board
STEMI, PCI
Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevation Myocardial Infarction
STEMI represents the subtype of ACS with the worst prognosis, associated with high mortality and an elevated risk of complications. The use of IVI guidance holds the potential to reduce the incidence of MACE.
- Trial name
- INSIGHT-STEMI (NCT07616024)
- Testing
- Intravascular Ultrasound, Coronary angiography guidance
- Where
- China
- Volunteers
- 2,488 people
- Sponsor
- Shanghai Zhongshan Hospital
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