Clinical trials: ST-Segment Elevation Myocardial Infarction
ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients
This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g.
- Conditions
- ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05698719
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 111 people
- Sponsor
- Erasmus Medical Center
ST Elevation Acute Myocardial Infarction
Does Cyclosporine ImpRove Clinical oUtcome in ST Elevation Myocardial Infarction Patients at 3 Years of Follow-up. CIRCUS II Study
Infarct size is a major determinant of vital prognosis after AMI. We recently reported that cyclosporine A, when administered immediately prior to PCI reperfusion, can significantly reduce infarct size in STEMI patients.
- Trial name
- CIRCUS II (NCT02934217)
- Testing
- Injection of Cyclosporin, Echocardiography
- Where
- France
- Volunteers
- 868 people
- Sponsor
- Hospices Civils de Lyon
ST Elevation Myocardial Infarction, Heart Failure
Effect of Levosimendan on Left Ventricular Systolic Function and Heart Failure After PCI in Patients With Acute Anterior Myocardial Infarction
Reperfusion therapy for acute ST segment elevation myocardial infarction (STEMI) can significantly reduce mortality, but patients may still have heart failure and adverse cardiovascular events due to massive myocardial loss.
- Trial name
- NCT04970238
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhijun Sun
Acute Myocardial Infarction
Evaluation of Neointimal Coverage of EES and BMS After Implantation in STEMI Patients by Optical Coherence Tomography
Primary percutaneous coronary intervention (PCI) represents the preferred reperfusion strategy for patients with ST-segment elevation myocardial infarction (STEMI), since it is more effective than thrombolytic regimens in…
- Trial name
- NeoCover (NCT01875835)
- Testing
- Xience™ V stent (Abbott Vascular, Santa Clara, California, USA), Multilink-Vision stent(Abbott Vascular, Santa Clara, California, USA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Harbin Medical University
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
Angina, Unstable, Myocardial Infarction
Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome
To compare efficacy and safety of dalteparin compared to unfractionated heparin in patients of non ST elevation acute coronary syndromes who are planned to undergo coronary interventions (angioplasty or bypass surgery)
- Trial name
- NCT00435487
- Testing
- Dalteparin ( Fragmin), Unfractionated heparin
- Where
- 8 sites in India
- Volunteers
- 173 people
- Sponsor
- Pfizer
Ischemic Cardiovascular Disease, Magnetic Resonance
Tissue Characterization in STEMI Using Cardiac MRI: a Multicenter Registry
This multicenter registry includes patients with a first ST-segment elevation myocardial infarction (STEMI) who underwent cardiac magnetic resonance (CMR) imaging during the acute phase and follow-up.
- Trial name
- NCT07291999
- Where
- 3 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
STEMI, Diabetes Mellitus
Analysis of the Microbiota and STEMI
Hyperglycemia is a common finding in patients diagnosed with acute coronary syndrome (ACS), and an independent predictor of mortality in patients with and without diabetes.
- Conditions
- STEMI, Diabetes Mellitus, Microbial Colonization
- Trial name
- NCT03439592
- Testing
- collection of fecal material
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Acute Myocardial Infarction, Ischemia-reperfusion Injury
The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
In Denmark, 12.000 people a year, is struck by acute myocardial infarction. A third of these cannot be saved before treatment is possible.
- Trial name
- NCT01172171
- Testing
- Melatonin, N-acetyl-5-methoxytryptamine, Isotonic saline, Natrium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 41 people
- Sponsor
- Herlev Hospital
Myocardial Infarction, ST Elevation Myocardial Infarction
Early Discharge Pathway Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT06040528
- Where
- 2 sites in United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Acute ST SEgment Elevation Myocardial Infarction
Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance
TEG is an established technique to assess the quality of clot formation' used mainly in surgery and obstetrics to determine possible bleeding diathesis.
- Trial name
- TEG (NCT00697021)
- Testing
- Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG, Aspirin 100mg and Plavix 75mg
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Myocardial Infarction, Reperfusion Injury
Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries.
- Trial name
- NCT00265239
- Testing
- edaravone
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University
Coronary Heart Disease, ST Elevation Myocardial Infarction
Prognostic Value of the AMR Measured After PPCI in STEMI Patients
The goal of this observational study is to learn about in STEMI with Primary PCI Patients. The main questions it aims to answer are: To determine the value of AMR in predicting the long-term clinical prognosis of patients with…
- Trial name
- EARLYMYOAMR (NCT05653765)
- Where
- 5 sites in China
- Volunteers
- 2,663 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
STEMI, STEMI - ST Elevation Myocardial Infarction
The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor
Fast and accurate platelet inhibition is an important therapeutic goal in the acute treatment of patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- ON-TIME 3 (NCT03400267)
- Testing
- Paracetamol, Fentanyl
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- A.H. Tavenier
Acute Myocardial Infarction
A Study of INO-1001, an Intravenous PARP (Poly [ADP Ribose] Polymerase) Inhibitor in Acute Heart Attack Patients Undergoing Primary Percutaneous Coronary Intervention
The primary purpose of this study is to assess the safety of INO-1001 in subjects who have experienced a heart attack and are to be treated with coronary angioplasty.
- Trial name
- NCT00271765
- Testing
- INO-1001
- Where
- 16 sites in United States, Israel
- Volunteers
- 40 people
- Sponsor
- Inotek Pharmaceuticals Corporation
STEMI - ST Elevation Myocardial Infarction
Emergency Medical Services (EMS) Telehealth to Speed STEMI Reperfusion
The aim of this study is to evaluate the impact of a Telehealth program on the time from First Medical Contact (FMC) to Reperfusion in STEMI (ST-elevation myocardial infarction) patients, by supporting local paramedics in their…
- Trial name
- THOR (NCT06945900)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
ST Elevation Myocardial Infarction
Oxford Acute Myocardial Infarction - Pressure-controlled Intermittent Coronary Sinus Occlusion
The OxAMI-PICSO is a study about the use of pressure controlled intermittent coronary sinus occlusion (PICSO) to improve the treatment of patients presenting with heart attack.
- Trial name
- OxAMI-PICSO (NCT03473015)
- Testing
- PICSO
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- Oxford University Hospitals NHS Trust
ST Elevation Myocardial Infarction
Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI
Effect of upstream treatment with high intensity statin on the outcome of ST segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention
- Trial name
- NCT04754789
- Testing
- Atorvastatin, Aspirin
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myocardial Infarction
Efficacy and Safety of OPL-0301 Compared to Placebo in Adults With Post-Myocardial Infarction (MI)
Study OPL-0301-201 is intended to generate efficacy and safety data of OPL-0301 in participants with post-myocardial infarction (MI) left ventricular dysfunction (LVD)
- Trial name
- RESTORE (NCT05327855)
- Testing
- OPL-0301 Dose 1, OPL-0301 Dose 2
- Sponsor
- Valo Health, Inc.
ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices
Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI
1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices. 2. To assess the association between repolarization indices among early, late presentation in relation to…
- Conditions
- ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices, Total Ischemic Time, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07175259
- Testing
- Echocardiography
- Volunteers
- 500 people
- Sponsor
- Assiut University