Clinical trials: ST-elevation Myocardial Infarction
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Ischemic Heart Disease, Myocardial Infarction
Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study
RITA-MI aims to develop of a novel therapeutic concept to target the immune response in patients with acute myocardial infarction (MI) by depleting B-cells with a single injection of Rituximab which is approved for clinical use…
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Inflammation
- Trial name
- RITA-MI (NCT03072199)
- Testing
- RiTUXimab Injection
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Acute ST Elevation Myocardial Infarction
The Efficacy and Safety of rhTNK-tPA in Comparison With Alteplase(Rt-PA) as Fibrinolytic Therapy of Acute STEMI
This study is aiming to test the hypothesis that efficacy of rhTNK-tPA was not inferior to rt-PA with respect to the 30-day MACCE rates after fibrinolytic therapy for STEMI patients.
- Trial name
- NCT02835534
- Testing
- rhTNK-tPA, alteplase
- Where
- China
- Volunteers
- 818 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
STEMI, Myocardial Infarction
Early Diagnosis of Acute Myocardial Infarction: Impact of an Educational and Organizational Intervention
The hypothesis is that an educational program aimed at emergency nurses and the implementation of measures at the organizational level reduce the time between arrival at the emergency room and the opening of the artery or balloon…
- Conditions
- STEMI, Myocardial Infarction, Nurses, Education
- Trial name
- NCT04333381
- Testing
- Educational and organizational intervention, Common Practice
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Myocardial Infarction, Acute Coronary Syndromes
Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis
During primary percutaneous coronary intervention, distal embolization of thrombus and impaired microvascular perfusion has been associated with an increased mortality.
- Trial name
- NCT02552407
- Testing
- Manual Aspiration Thrombectomy
- Volunteers
- 18,000 people
- Sponsor
- Population Health Research Institute
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
"Discovery2" Study of Using MCG at Emergency Departments
The purpose of this research is to collect the magnetic signals from the heart to identify features that may help Emergency Department (ED) doctors differentiate high and low risk patients for heart related chest pain.
- Conditions
- Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD), Chest Pain, NSTE-ACS (NSTEMI and UA)
- Trial name
- Discovery2 (NCT07822581)
- Testing
- Magnetocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- SB Technology, Inc.
Myocardial Infarction, Angioplasty, Transluminal, Percutaneous Coronary
Arterial Access for Coronary Intervention in Myocardial Infarction
The aim of this study is to compare the radial and femoral access for percutaneous interventions in the acute phase of the ST elevation acute myocardial infarction in terms of efficacy and security.
- Conditions
- Myocardial Infarction, Angioplasty, Transluminal, Percutaneous Coronary, Myocardial Reperfusion
- Trial name
- NCT00356044
- Testing
- Coronary angioplasty
- Where
- 3 sites in Spain
- Volunteers
- 439 people
- Sponsor
- Hospital Juan Canalejo
Cardiovascular Disease
The Effect of Morphine on Prasugrel Absorption in STEMI Patients
Heart Attacks are a major cause of death in this country. When patients have a heart attack, they are treated with anti-clotting drugs, one of which is a drug called Prasugrel.
- Trial name
- NCT01536964
- Testing
- morphine, saline
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
ST Segment Elevation Myocardial Infarction, Primary Percutaneous Coronary Intervention
Prevention of Coronary Slow Flow or No-Reflow During PPCI in Patients With Acute STEMI
Primary percutaneous coronary intervention (PPCI) is the gold standard of treatment of ST segment elevation myocardial infarction (STEMI).Slow flow / no-reflow phenomenon following PPCI in STEMI patients has been a serious and…
- Trial name
- NOSLOWFLOW-Ⅰ (NCT03406819)
- Testing
- Nitroprusside Sodium, Tirofiban Hydrochloride, Heparinized saline
- Where
- 28 sites in China
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Acute Myocardial Infarction
Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction
This study is a first-in-human assessment of safety of using UCMSC in patients with AMI via a combination of IC and IV stem cell administration.
- Trial name
- NCT04056819
- Testing
- Allogeneic umbilical cord mesenchymal stem cells
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Acute Myocardial Infarction
Paced Electrocardiogram Requiring Fast Emergent Coronary Therapy (PERFECT) Study
The number of patients with cardiovascular implantable electronic devices (CIED), including ventricular pacemakers, continues to increase.
- Trial name
- PERFECT (NCT02765477)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Hennepin County Medical Center, Minneapolis
ST Elevation Myocardial Infarction, No-Reflow Phenomenon
Rivaroxaban for Slow Coronary Flow After PCI in STEMI
The goal of this clinical trial is to learn if drug Rivaroxaban works to improve slow flow in STEMI patients after PCI in adults. It will also learn about the safety of drug Rivaroxaban.
- Trial name
- NCT07195812
- Testing
- Dual Antiplatelet (DAPT) Therapy, Rivaroxaban
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myocardial Infarction, ST Elevation Myocardial Infarction
Early Discharge Pathway Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT06040528
- Where
- 2 sites in United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
NSTEMI
The Problem of Incomplete Myocardial Revascularization in Percutaneous Coronary Intervention in Patients With NSTEMI
The study included all patients admitted to the intensive care unit of the district hospital and sent to the angiographic Department for diagnosis and performance of PCI with a diagnosis of NSTEMI, including myocardial infarction…
- Trial name
- CONTRAST (NCT04490928)
- Where
- Russia
- Volunteers
- 139 people
- Sponsor
- National Research Center for Preventive Medicine
Coronary Stenosis, Acute Coronary Syndrome
Systemic, Pancoronary and Local Coronary Vulnerability
The aim of the VIP study is to investigate the impact of vulnerability markers (inflammatory serum biomarkers for systemic vulnerability, coronary shear stress and vulnerability mapping for pancoronary vulnerability, and…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- VIP (NCT03606330)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Inflammation, Acute ST Segment Elevation Myocardial Infarction
A Cohort Study of Correlation Between Mast Cells and Prognosis in Patients With Acute Myocardial Infarction
By including patients with acute myocardial infarction, mast cell markers were analyzed and the relationship between mast cells and patients with acute myocardial infarction was analyzed
- Conditions
- Inflammation, Acute ST Segment Elevation Myocardial Infarction, Prognosis
- Trial name
- NCT05802667
- Testing
- Tryptase
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Acute Non-ST Elevation Myocardial Infarction
DLBS1033 for Acute NSTEMI Without Early Coronary Revascularization
This is a prospective, randomized, double-blind, double-dummy, and controlled study of DLBS1033 in the management of acute non-ST elevation myocardial infarction (NSTEMI) without early coronary revascularization.
- Trial name
- NCT02146664
- Testing
- DLBS1033
- Where
- 2 sites in Indonesia
- Sponsor
- Dexa Medica Group
Acute Myocardial Infarction
Erythropoietin in Acute Myocardial Infarction
Erythropoietin (EPO) is a naturally occuring hormone which regulates the body's response to lack of oxygen and controls the number of red cells in the blood.
- Trial name
- NCT00149058
- Testing
- Erythropoietin
- Where
- 2 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- Hammersmith Hospitals NHS Trust
Acute Myocardial Infarction, Cardiovascular Diseases
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
The goal of this randomized, double-blind, placebo-controlled clinical trial is to investigate the immunological effects of influenza vaccination outside of the influenza season on arterial inflammation in patients with a recent…
- Conditions
- Acute Myocardial Infarction, Cardiovascular Diseases, Inflammatory Response
- Trial name
- ELIMINATE (NCT06336317)
- Testing
- Influenza vaccine
- Where
- 3 sites in Denmark, Sweden and 1 more
- Volunteers
- 90 people
- Sponsor
- Region Örebro County
ST Elevation Myocardial Infarction, Coronary Artery Disease
Distal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI
Recently, a novel distal transradial, through anatomical snuffbox, approach has been proposed for undertaking percutaneous coronary angiography and interventions.
- Conditions
- ST Elevation Myocardial Infarction, Coronary Artery Disease, Distal Transradial Artery, Transradial Artery
- Trial name
- DR-STEMI (NCT05605288)
- Testing
- Coronary angiography +/- percutaneous coronary intervention
- Where
- 3 sites in Belgium, Greece and 1 more
- Volunteers
- 554 people
- Sponsor
- University Hospital of Patras