Clinical trials: ST-elevation Myocardial Infarction (STEMI)
ST Elevation Myocardial Infarction
Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure.
- Trial name
- REMOD-TEP (NCT02789098)
- Testing
- (15)-O water positron emission tomography and Biomarkers
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
ST Segment Elevation Myocardial Infarction
Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Non Culprit Lesions in Patients With ST-segment Elevation Myocardial Infarction
Functional assessment of non-culprit lesions during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome could improve risk stratification and shorten the duration of hospital stay by decreasing the…
- Trial name
- WAVE (NCT02869906)
- Testing
- FFR and iFR
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
ST-elevation Myocardial Infarction (STEMI), In-stent Restenosis
Functional Milk Supplementation to Reduce In-Stent Restenosis in STEMI Patients (SMASOEA Trial)
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily supplementation with functionalized bovine milk, enriched with bioactive peptides and optimized lipid profile, on coronary in-stent…
- Trial name
- SMASOEA (NCT07176104)
- Testing
- Functional Bovine Milk, Non-Functional Bovine Milk
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Raffaele Marfella
Cardiovascular Diseases
A Randomized, Single-blind, Controlled Clinical Study of Cardiomyopeptidin on Improving Ischemia-reperfusion Injury in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI
This study aim to investigate the myocardium protection effect of cardiomyopeptidin in patients undergoing primary PCI for ST-elevation myocardial infarction through myocardial enhanced MRI.
- Trial name
- NCT06155110
- Testing
- cardiomyopeptidin
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese PLA General Hospital
Anterior Myocardial Infarction
TACTIC Coronary Thrombus Aspiration With Cath Rx In Anterior Myocardial Infarction: A Randomized Control Trial.
The aim of this study is to evaluate the impact of sustained thrombectomy with INDIGO ASPIRATION SYSTEM using CAT RX versus no thrombectomy during primary percutaneous coronary intervention (PPCI) on microvascular obstruction and…
- Trial name
- TACTIC (NCT06887413)
- Testing
- THROMBOASPIRATION WITH INDIGO SYSTEM
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Ceric Sàrl
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
This study aims to evaluate if the 1-hour rule-in/rule-out algorithm for a high-sensitivity cardiac troponin T (hs-cTnT) is safe and effective for use in the primary care where the patients have a lower pretest probability of an…
- Conditions
- Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Angina, Unstable, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- OUT-ACS (NCT02983123)
- Testing
- 1-hour hs-cTnT
- Where
- Norway
- Volunteers
- 1,750 people
- Sponsor
- Oslo University Hospital
STEMI - ST Elevation Myocardial Infarction, AMI
SuperSaturated Oxygen Comprehensive Observational Registry
The SuperSaturated Oxygen Comprehensive Observational Registry (SSCORE) registry, a prospectively designed observational study, aims to evaluate the clinical utility, infarct size reduction, and cost-effectiveness of SSO2 Therapy…
- Trial name
- SSCORE (NCT06438315)
- Testing
- KCCQ, Eq5D, cMRI (Subset of patients)
- Where
- 27 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- TherOx
Non-ST-elevation Myocardial Infarction
ImmeDiate Versus EArLy Invasive Approach in Non-ST-Elevation Myocardial Infarction (IDEAL NSTEMI)
Of estimated 140,000 cases of acute myocardial infarction admitted to hospitals in Germany per year, approximately 50% present with Non-ST-elevation myocardial infarction (NSTEMI).
- Trial name
- IDEAL NSTEMI (NCT00954668)
- Testing
- immediate angiography and revascularization, early invasive angiography
- Where
- Germany
- Sponsor
- University of Leipzig
ST-elevation Myocardial Infarction (STEMI)
Low-dose Evaluation of Aspirin After STEMI Patients With PCI: A Multicenter, Double-blind, Randomized Controlled Clinical Trial
The study aims to optimize the dual antiplatelet therapy regimen for patients with STEMI after PCI, focusing on addressing the following key technical challenges: establishing an effectiveness evaluation system for a low-dose…
- Trial name
- LEAST (NCT06756945)
- Testing
- aspirin 100 mg once daily (two 50 mg aspirin tablets) plus ticagrelor 90 mg twice daily
- Volunteers
- 3,612 people
- Sponsor
- Beijing Anzhen Hospital
ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN)
Beyond the Mehran Risk Score: Predictive Value of Total Ischemic Time for Contrast-Induced Nephropathy in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.
Contrast-Induced Nephropathy (CIN) is a serious complication following primary percutaneous coronary intervention (PCI) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN), Acute Kidney Injury
- Trial name
- NCT07826572
- Testing
- Total Ischemic Time Evaluation
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myocardial Infarction, Reperfusion Injury
Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries.
- Trial name
- NCT00265239
- Testing
- edaravone
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University
Contrast Induced Nephropathy
Effects of Hydration to Prevent Contrast Induced Nephropathy in PCI for ST-elevation Myocardial Infarction.
The aim of the study is to test the efficacy of low versus high volume hydration and two different solutions (sodium chloride versus sodium bicarbonate) in preventing contrast induced nephropathy (CIN) in ST elevation myocardial…
- Trial name
- CINIMA (NCT00639912)
- Testing
- sodium chloride, sodium bicarbonate
- Where
- 5 sites in Italy
- Volunteers
- 599 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
ST-segment Elevation Myocardial Infarction (STEMI)
A Prospective Multicenter Clinical Study on the Long-term Prognosis of Patients With ST-segment Elevation Myocardial Infarction Using Cardiac Magnetic Resonance Imaging.
This prospective, multicenter study was designed to develop and validate a risk prediction model for major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction (STEMI) based on…
- Trial name
- NCT07057492
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese PLA General Hospital
Vascular Diseases, Cardiovascular Diseases
The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction)
The purpose of this study is to test the hypothesis that the intracoronary transplantation of autologous mononuclear and CD 133 + bone marrow cells will improve left ventricular contractile function and will reduce the combined…
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- ESTABOMA (NCT01748383)
- Testing
- Transplantation of BMMCs, Transplantation of CD 133+ cells, stenting of IRA
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Russian Academy of Medical Sciences
Fractional Flow Reserve, ST-segment Elevation Myocardial Infarction
Fractional Flow Reserve Versus Angiography for Guiding Selective Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction
To assess the outcomes of patients with ST-segment elevation myocardial infarction (STEMI) assigned to fractional flow reserve (FFR) and angiography-guided selective percutaneous coronary intervention (PCI).
- Conditions
- Fractional Flow Reserve, ST-segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- NCT02670005
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Coronary Artery Disease, Myocardial Infarction
Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Stent Implantation
Coronary artery disease is one of the most prevalent diseases in the western countries. A waxy substance called plaque can build up inside the coronary arteries.
- Trial name
- OCTACS (NCT02272283)
- Testing
- Percutaneous coronary intervention with Nobori biolimus-eluting stent implantation
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
ST Elevation Myocardial Infarction, STEMI
Rheolytic Thrombectomy in Patients With Acute STEMI and Large Thrombus Burden
Coronary obstruction by an occlusive thrombus complicating a ruptured or eroded atherosclerotic plaque is the most frequent pathologic substrate of acute myocardial infarction (AMI).
- Trial name
- Rheo-STEMI (NCT02604394)
- Testing
- Rheolytic Thrombectomy, Conventional PCI
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Magdi Yacoub Heart Foundation
Acute Myocardial Infarction
Stentys Coronary Stent System Clinical Trial in Patients With Acute Myocardial Infarction
This study will test compare the Stentys Stent with the Multi-Link Vision™ stent system (Abbott Vascular Inc.)in patients with a heart attack. It is expected that the Stentys stent is not worse than the Vision stent.
- Trial name
- APPOSITION V (NCT01732341)
- Testing
- STENTYS self-apposing stent, VISION balloon-expandable stent
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 318 people
- Sponsor
- Stentys
ST-segment Elevation Myocardial Infarction (STEMI)
Thrombus Aspiration in STEMI Patients With High Thrombus Burden
This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included.
- Trial name
- NCT04212494
- Testing
- Thrombus aspiration, PCI Alone
- Where
- 50 sites in China
- Volunteers
- 3,838 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute ST Segment Elevation Myocardial Infarction
Safety and Efficacy of TCD-10023 (Ultimaster) Drug-eluting Stent in STEMI Patients - MASTER Study
The aim of the study is to demonstrate the safety and efficacy of the TCD-10023 (Ultimaster) sirolimus eluting stent in patients with acute ST-elevation myocardial infarction (STEMI), by proving superiority with respect to…
- Trial name
- MASTER (NCT02828683)
- Testing
- PCI in patients with ST-elevation myocardial infarction
- Where
- 13 sites in Brazil, Italy and 3 more
- Volunteers
- 500 people
- Sponsor
- Terumo Europe N.V.
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