Clinical trials: ST-elevation Myocardial Infarction (STEMI)
Acute Coronary Syndrome, ST Elevation Myocardial Infarction
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus…
- Conditions
- Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- ATTRACTIVE (NCT05554588)
- Testing
- Intrathrombus Thrombolysis During Primary PCI, Aspiration Thrombectomy During Primary PCI
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- China-Japan Friendship Hospital
Heart Diseases
Evaluation of CCR2 in Patients Post Myocardial Infarction
To determine the feasibility of 64Cu-DOTA-ECL1i, an investigational PET imaging drug, at the cellular level in the myocardium for individuals who have suffered a heart attack or who have other inflammatory heart disease.
- Trial name
- NCT05107596
- Testing
- 64Cu-DOTA-ECL1i
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Acute Myocardial Infarction
FFR Versus Angiography-Guided Strategy for Management of AMI With Multivessel Disease
The aim of the study is to compare clinical outcomes following fractional flow reserve (FFR)-guided versus angiography only guided strategy in treatment of non-infarction related artery (non-IRA) stenosis in patients with acute…
- Trial name
- FRAME-AMI (NCT02715518)
- Testing
- PCI using 2nd generation drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel
The administration of these drugs is realized according to the European Society of Cardiology guidelines. All patients will be pretreated with aspirin 300 mg orally, heparin iv to maintain an activated clotting time of >250 sec…
- Conditions
- Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032290
- Testing
- Assessment of Coronary Flow Reserve, Percutaneous coronary intervention, ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Unstable Angina, Myocardial Infarction
Early Versus Delayed Timing of Intervention in Patients With Acute Coronary Syndromes
The timing of intervention study is a prospective, randomized, international, multicentre comparison of the relative efficacy, safety, and cost effectiveness of a management strategy of coronary angiography and intervention…
- Trial name
- TIMACS (NCT00552513)
- Testing
- Early Coronary Intervention, Delayed Coronary Intervention
- Where
- Canada
- Volunteers
- 3,031 people
- Sponsor
- Population Health Research Institute
ST Segment Elevation Myocardial Infarction
ST Segment Resolution After Primary Percutaneous Coronary Intervention.
To compare the ST segment resolution after primary percutaneous coronary intervention (PPCI) with and without thrombus aspiration in patients with ST segment elevation myocardial infarction as ST segment resolution is the best…
- Trial name
- STresolution (NCT03895983)
- Testing
- Percutaneous primary coronary intervention
- Volunteers
- 270 people
- Sponsor
- Assiut University
Acute Myocardial Infarction
Clinical Presentations Before AMI Onset and Coronary Atherosclerosis
This study aimed to evaluate the incidence of preinfarction angina in AMI patients and test the hypothesis that different clinical presentations before AMI onset can affect coronary plaque morphologies in AMI patients .
- Trial name
- NCT03107624
- Where
- China
- Volunteers
- 305 people
- Sponsor
- Harbin Medical University
Myocardial Infarction, Anterior Wall, Myocardial Remodeling, Ventricular
Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI
Prospective, randomized, double-blind, placebo-controlled, proof of concept study. Patients with first anterior wall STEMI will be randomized with 4±2 days after symptoms beginning to receive ddMTX-LDE at the dose of 40 mg/m2 IV…
- Trial name
- NCT03516903
- Testing
- Methotrexate, Folic Acid
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo
STEMI - ST Elevation Myocardial Infarction
Asian Registry of the BioFreedom Stent for STEMI Patients
The BioFreedom BA9 (Stainless Steel) Drug Coated Stent is an approved stent that is already commercially available in Europe and Asia.
- Trial name
- NCT03609346
- Testing
- PCI
- Where
- 5 sites in Hong Kong, Singapore and 3 more
- Volunteers
- 914 people
- Sponsor
- Biosensors Europe SA
Myocardial Infarction
Impacts of Superselective Infarct-related Artery (IRA) Infusion of Tirofiban on Myocardial Reperfusion and Bleeding Complications in Acute Myocardial Infarction (AMI) Patients
Superselective IRA infusion of tirofiban may improve myocardial reperfusion and reduce bleeding complications in AMI patients.
- Trial name
- SUIT-AMI (NCT01181388)
- Testing
- administration of tirofiban by thrombus aspiration catheter in infarct-related artery, administration of tirofiban by guide catheter
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
ST Elevation Myocardial Infarction, Non ST Segment Elevation Acute Coronary Syndrome
ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction
The purpose of this study is to evaluate analgesic efficacy of inhaled methoxyflurane vs intravenous morphine in patients presenting with acute ST-elevation (STEMI) / non ST-elevation acute coronary syndrome (NSTE-ACS)
- Trial name
- ANEMON (NCT04476173)
- Testing
- Methoxyflurane - Penthrox, Morphine
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
Safety and Effectiveness of the Crystalline Sirolimus-Eluting Device in Patients With Coronary Artery Disease
This prospective, multicenter, post-market observational study aims to evaluate the safety and effectiveness of the crystalline sirolimus-coated balloon (SeQuent® Sirolimus-Coated Balloon) for the treatment of coronary artery…
- Conditions
- Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Stable Angina, Unstable Angina, NSTEMI, Drug Coated Balloon
- Trial name
- SECuRE (NCT07444957)
- Where
- Spain
- Volunteers
- 1,118 people
- Sponsor
- Fundación Interhospitalaria para la Investigación Cardiovascular FIC
ST Elevation Myocardial Infarction
TIMES: Ticagrelor vs. Placebo/ Clopidogrel With Aspirin in Anterior STEMI Patients Treated With Primary PCI
This is a single-centred, double blind randomized controlled trial comparing ticagrelor with placebo in clopidogrel and aspirin loaded patients.
- Trial name
- NCT03145194
- Testing
- Ticagrelor
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
ST-segment Elevation Myocardial Infarction (STEMI), Left Ventricular Thrombus
Anti-CoagulaTion on Left Ventricular Thrombus After ST Segment Elevation Myocardial Infarction
Contemporary data are lacking regarding the management of left ventricular thrombus (LVT) developed after ST segment elevation myocardial infarction
- Trial name
- ACTonLVT (NCT05892042)
- Testing
- Rivaroxaban 15 MG [Xarelto]
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Jilin University
Anterior STEMI
The RECOVERY Study: Using Supersaturated Oxygen Therapy To Treat Small Vessel Blockages After a Heart Attack
The study tests whether adding supersaturated oxygen (SSO₂) therapy to standard stent treatment can improve heart recovery after a major heart attack (anterior STEMI).
- Trial name
- NCT07000266
- Testing
- Percutaneous Coronary Intervention (PCI), Diagnostic Imaging, Device Treatment
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
STEMI
CMR Repeatability in STEMI
The investigators propose to conduct a study to measure the reproducibility of CMR parameters that have been used to predict outcome following PPCI: infarct size, left ventricular volumes, myocardial salvage, microvascular…
- Trial name
- NCT01468662
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Bristol
Myocardial Infarction
Cohort of STEMI Patients 2
ST-segment elevation myocardial infarction (STEMI) is an acute condition that accounts for 75% of sudden deaths in adults over 35 years of age and more than half of all cases of chronic heart failure.
- Trial name
- HIBISCUS STEMI (NCT05794022)
- Testing
- MRI, Biocollection, Quality of life questionaries
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Acute Coronary Syndrome, Myocardial Infarction
Triage Now: an Observational, Prospective Multimarker Study of Biomarkers in Patients Presenting With Chest Pain
Study of diagnostic tests for heart attack for patients with chest pain.
- Trial name
- NCT00380094
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Abbott RDx Cardiometabolic
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
Non-ST-elevation Myocardial Infarction
Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)
Whereas thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI) is recommended by current guidelines, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI).
- Trial name
- NCT01612312
- Testing
- Thrombectomy, Standard percutaneous coronary intervention
- Where
- 7 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University of Leipzig
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