Clinical trials: ST-elevation Myocardial Infarction (STEMI)
STEMI
Optical Coherence Tomography in STEMI
The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.
- Trial name
- NCT02791178
- Testing
- Optical coherence tomography (OCT), Index of microcirculatory resistance (IMR), Cardiac MRI
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National Heart Centre Singapore
Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential
CHIP in Health and Disease
Clonal hematopoiesis (CH), including clonal hematopoiesis of indeterminate potential (CHIP), is an age-associated condition characterized by the expansion of hematopoietic stem and progenitor cell clones carrying acquired somatic…
- Conditions
- Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential, Clonal Cytopenia of Undetermined Significance (CCUS), Myelodysplastic Syndrome
- Trial name
- CHIP2 (NCT07780552)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
STEMI, Primary PCI
Early Administration of Heparin At FMC for PPCI of STEMI Patients
Heparin is the first choice of anticoagulation drug for primary PCI of STEMI patients. However, the priority of use of hepairn in first medical contact or in Cathlab has not yet studied.
- Trial name
- HELP-PCI (NCT05329155)
- Testing
- Heparin Sodium Injection
- Where
- China
- Volunteers
- 1,145 people
- Sponsor
- Renmin Hospital of Wuhan University
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III All-comers Orsiro Safety and Performance Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- BIOFLOW-III (NCT01553526)
- Where
- 43 sites in Austria, Chile and 11 more
- Volunteers
- 1,356 people
- Sponsor
- Biotronik AG
Myocardial Infarction
GLP-1 on Non-ST-Segment Elevation Myocardial Infarction
The investigators planned to evaluate the effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
- Trial name
- NCT02577848
- Testing
- GLP-1
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Acute ST Segment Elevation Myocardial Infarction, Acute Coronary Syndrome
Comparing Ticagrelor and Clopidogrel Pharmacodynamics After Thrombolysis
This study involves doing platelet function testing in patients who have undergone fibrinolysis. Fibrinolysis (Use of clot busting medicine in heart attack) is the standard of care to restore blood flow in blocked arteries as…
- Trial name
- TACAT (NCT02048085)
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Sponsor
- Medical Center of South Arkansas
Reperfusion Injury, Myocardial
Effects of Melatonin on Reperfusion Injury
Acute myocardial infarction is a major cause of mortality and morbidity. Primary percutaneous coronary intervention (pPCI) is currently the most effective treatment strategy in acute myocardial infarction.
- Trial name
- NCT03303378
- Testing
- melatonin (Helsinn Chemical Co, Biasca, Switzerland)
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Infarction, Inflammation
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
Oxygen treatment is widely used in acutely ill patients. In particular, oxygen treatment is routinely used in acute coronary syndrome (ACS) patients with suspected acute myocardial infarction and variably recommended in…
- Conditions
- Myocardial Infarction, Inflammation, Acute Coronary Syndrome (ACS), Reperfusion Injury
- Trial name
- NCT02286544
- Testing
- Salmonella typhi vaccine (Typhim Vi®), Oxygen (Oxymask®), Atorvastatin
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Myocardial Reperfusion, STEMI - ST Elevation Myocardial Infarction
Impact of Injection Pressure on Myocardial Reperfusion During Primary PCI
Percutaneous coronary intervention for myocardial infarction with ST elevation could be complicated with thrombus embolisation to the more distal segments of the culprit artery.
- Trial name
- ImPress (NCT03445364)
- Testing
- Use of different injection pressure during primary PCI
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Sestre Milosrdnice
Sarcoidosis With Myocarditis, Sarcoidosis
Cell Free DNA in Cardiac Sarcoidosis
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing…
- Conditions
- Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction
- Trial name
- cfDNA in CS (NCT03858777)
- Testing
- cell free DNA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nabeel Hamzeh
Acute Coronary Syndrome, ST Elevated Myocardial Infarction
the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry
The global burden and threat of non-communicable diseases (NCDs) have become a major health challenge that undermines social and economic development throughout the world.
- Conditions
- Acute Coronary Syndrome, ST Elevated Myocardial Infarction, Non ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- PERFUSION (NCT04887571)
- Testing
- No Intervention - Observational Registry
- Where
- 4 sites in South Africa
- Volunteers
- 870 people
- Sponsor
- University of Cape Town
ST-elevation Myocardial Infarction (STEMI)
Effect of Digitally Supported Medical Nutrition Therapy on Left Ventricular Ejection Fraction in Patients With ST-Elevation Myocardial Infarction
This study is designed to investigate the effect of a nutrition program supported by digital content on heart function in patients who have experienced a heart attack with ST-elevation.
- Trial name
- NCT07427199
- Testing
- Digital Content-Supported Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Saglik Bilimleri Universitesi
ST Elevation Myocardial Infarction
The Effect of Low-Level Tragus Stimulation on Echocardiographic Parameters in Patients With ST-Segment Elevation Myocardial Infarction - A Single-Centre Randomized Control Trial
The goal of this clinical trial is to learn the effect of low level tragus stimulation (LLTS) on echocardiographic parameter in patient with ST-segment Elevation Myocardial Infarction (STEMI) who undergo primart percutaneous…
- Trial name
- ELITE-STEMI (NCT07058857)
- Testing
- Parasym Neuromodulation Device (Treatment Group)
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Diponegoro
Coronary Artery Disease, Aortic Valve Disease
Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology
The goal of the 3D-CARDIOPATH study is to investigate the potential added value of emerging 3D imaging modalities by imaging ex vivo cardiac specimens (diseased coronary arteries, calcific aortic valves, and thrombotic materials)…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Aortic Valve Calcification, STEMI
- Trial name
- 3D-CARDIOPATH (NCT05975567)
- Testing
- Three-dimensional imaging of the collected cardiac specimens
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Stent Thrombosis, Myocardial Infarction, Acute
TADCLOT- a Double Blind Randomized Controlled Trial
Compare the safety and efficacy of a twice-daily Clopidogrel regimen vs. Ticagrelor in reducing major adverse events in patients undergoing primary PCI in a double-blind randomized controlled trial.
- Trial name
- TADCLOT (NCT06318481)
- Testing
- Ticagrelor 90 MG, Clopidogrel
- Where
- Pakistan
- Volunteers
- 2,200 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
STEMI
Cangrelor Following Ticagrelor Loading vs Ticagrelor Loading Alone in STEMI
Platelets and thrombus formation play a key role in the pathogenesis of acute coronary artery occlusion and subsequent myocardial infarction.
- Trial name
- NCT02943369
- Testing
- Ticagrelor 180 mg loading dose, Cangrelor 30 mcg/kg bolus + 4 mcg/kg/min
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Attikon Hospital
Myocardial Infarction
A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary Intervention
This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of RO4905417 in patients with non ST-elevation myocardial infarction (Non-STEMI) undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT01327183
- Testing
- Percutaneous Coronary Intervention (PCI), RO4905417
- Where
- 66 sites in United States, Canada and 2 more
- Volunteers
- 532 people
- Sponsor
- Hoffmann-La Roche
Acute Myocardial Infarction, STEMI
A Study of Acute Myocardial Infarction Using FDY-5301
The purpose of this study is to evaluate the safety, efficacy, and pharmacokinetics (PK) of three dose levels of FDY-5301 compared to placebo in STEMI patients undergoing PCI.
- Trial name
- NCT03470441
- Testing
- FDY-5301
- Where
- 23 sites in United States, Hungary and 2 more
- Volunteers
- 120 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
Stable Angina, Unstable Angina
Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
A multi-center, prospective, consecutive enrolled, observational registry. The population being studied includes all patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or…
- Conditions
- Stable Angina, Unstable Angina, ACS - Acute Coronary Syndrome, STEMI
- Trial name
- eCOBRA (NCT03103620)
- Testing
- COBRA PzF Coronary Stent System
- Where
- 18 sites in France
- Volunteers
- 1,027 people
- Sponsor
- CeloNova BioSciences, Inc.
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