Clinical trials: ST-elevation Myocardial Infarction (STEMI)
ST-elevation Myocardial Infarction (STEMI)
Low-dose Evaluation of Aspirin After STEMI Patients With PCI: A Multicenter, Double-blind, Randomized Controlled Clinical Trial
The study aims to optimize the dual antiplatelet therapy regimen for patients with STEMI after PCI, focusing on addressing the following key technical challenges: establishing an effectiveness evaluation system for a low-dose…
- Trial name
- LEAST (NCT06756945)
- Testing
- aspirin 100 mg once daily (two 50 mg aspirin tablets) plus ticagrelor 90 mg twice daily
- Volunteers
- 3,612 people
- Sponsor
- Beijing Anzhen Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
The aim of the study was to intervene in the Aerobic exercise time of patients with STEMI and to explore the optimal exercise time for STEMI patients
- Trial name
- NCT06385834
- Testing
- Morning aerobic exercise, Evening aerobic exercise
- Where
- China
- Volunteers
- 201 people
- Sponsor
- RenJi Hospital
LCx Occlusion STEMI, STEMI
Outcomes of Isolated LCx Occlusion
To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute occlusion.
- Trial name
- NCT06750328
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diabetes, STEMI
Sweetheart-Register: Risk Management of Diabetics with Acute Myocardial Infarction
The Sweetheart register (Risk management of Diabetics with acute myocardial infarction) documents both the prevalence of pathologic glucose metabolism in consecutive high-risk patients with STEMI and NSTEMI in daily hospital…
- Conditions
- Diabetes, STEMI, NSTEMI, Myocardial Infarction
- Trial name
- Sweetheart (NCT01197742)
- Where
- 2 sites in Germany
- Volunteers
- 2,772 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
ST-segment Elevation Myocardial Infarction (STEMI)
A Randomized Controlled Trial on the Efficacy and Safety of Butylphthalide in Reducing Myocardial Infarction Size and Improving Outcomes in STEMI Patients After Primary PCI
This study is a prospective, randomized, placebo-double-blind, multicenter clinical trial. The purpose of this study is to investigate whether "butylphthalide +PCI" combined treatment mode on the basis of traditional drug therapy…
- Trial name
- RISE (NCT06704685)
- Testing
- Butylphthalide
- Volunteers
- 40 people
- Sponsor
- Xiangya Hospital of Central South University
Myocardial Infarction, Acute, Myocardial Infarction First
MSCs for Prevention of MI-induced HF
Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction First, Myocardial Infarction, Anterior Wall, Cardiac Remodeling, Ventricular
- Trial name
- PREVENT-TAHA8 (NCT05043610)
- Testing
- Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment
- Where
- 3 sites in Iran
- Volunteers
- 420 people
- Sponsor
- Shiraz University of Medical Sciences
STEMI - ST Elevation Myocardial Infarction, Stent Thrombosis
TISSARA Trial: Ticagrelor Intervention to Reduce Stent Thrombosis and Acute MI Risk
Stent thrombosis (ST) remains a critical complication following primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI).
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Stent Thrombosis, Antiplatelet Agents
- Trial name
- TISSARA (NCT06667349)
- Testing
- Ticagrelor
- Where
- Pakistan
- Volunteers
- 1,727 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
ST Segment Elevation Myocardial Infarction (STEMI), Coenzyme Q10
Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI
Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling.
- Trial name
- ESCOMI (NCT06661018)
- Testing
- Coenzyme Q 10
- Where
- 2 sites in Indonesia
- Volunteers
- 46 people
- Sponsor
- Universitas Diponegoro
ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention
Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction
This is a double-blind, multicenter, randomized, placebo-controlled clinical trial. It is planned to enroll patients admitted with anterior ST-segment elevation myocardial infarction (STEMI) within 6h of symptom onset and undergo…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, Cardioprotection
- Trial name
- COOPERATION (NCT04912518)
- Testing
- Dexmedetomidine (DEX)
- Where
- 9 sites in China
- Volunteers
- 250 people
- Sponsor
- Harbin Medical University
STEMI - ST Elevation Myocardial Infarction
Correlation Between Triglyceride Glucose Index and Residual SYNTAX Score in STEMI Patients Undergoing PPCI
The goal of this study To check correlation between triglyceride glucose (TyG) index and residual SYNTAX score (RSS) in STEMI patients undergoing PPCI. 2.
- Trial name
- NCT06642259
- Testing
- Echocardiography
- Volunteers
- 185 people
- Sponsor
- Assiut University
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
STEMI, Elevated IMR (>32)
A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients.
Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving…
- Trial name
- RESTORE-MI (NCT03998319)
- Testing
- Tenecteplase (1/3 systemic weight based dose), Sterile water for injection (WFI)
- Where
- 22 sites in Australia, New Zealand
- Volunteers
- 445 people
- Sponsor
- University of Sydney
ST-segment Elevation Myocardial Infarction (STEMI)
Prolonged Clinical Follow-up of OPTIMA-5
The OPTIMA-5 trial is a prospective, multi-center, randomized, patient blinded, controlled trial comparing a single bolus of half-dose recombinant staphylokinase (r-SAK) with normal saline (NS) in patients with ST-segment…
- Trial name
- NCT05649696
- Testing
- Recombinant Staphylokinase, Normal Saline
- Where
- 8 sites in China
- Volunteers
- 210 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Neutrophils.Hypersegmented | Bld-Ser-Plas, STEMI - ST Elevation Myocardial Infarction
CLEAR SYNERGY Neutrophil Substudy
CLEAR SYNERGY is an international multi center 2x2 randomized placebo controlled trial of colchicine and spironolactone in patients with STEMI.
- Trial name
- NCT03874338
- Testing
- Colchicine Pill
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- NYU Langone Health
ST-segment Elevation Myocardial Infarction (STEMI)
The Prognostic Value of Anion Gap in Predicting Major Adverse Cardiovascular Events Among Patients With ST-Segment Elevation Myocardial Infarction
This study aims to evaluate the prognostic value of the anion gap in predicting major adverse cardiovascular events among patients with ST-segment elevation myocardial infarction.
- Trial name
- ANGIO-STEMI (NCT06586424)
- Testing
- Anion gap
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Diponegoro
Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI)
Predictive Value of NT-proBNP on MACEs After Acute Coronary Syndrome
The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a cardiac biomarker in predicting short-term major adverse cardiovascular events (MACEs) in patients with Acute coronary syndrome (ACS) has been insufficiently…
- Conditions
- Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Major Adverse Cardiac Events
- Trial name
- MACEstdy (NCT06569511)
- Testing
- N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitive cardiac troponin T (hs-cTnT)
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Haseki Training and Research Hospital
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
Atherosclerotic Cardiovascular Disease, STEMI
Real Life Lipid Management in Hospitals Not Participating in PENELOPE Trial - Control Population for PENELOPE
Guideline recommended evidence-based clinical care correlates with improved patient outcomes. In real life care, however, adherence to guideline recommendations remains suboptimal.
- Conditions
- Atherosclerotic Cardiovascular Disease, STEMI, Non STEMI
- Trial name
- PENELOPECTRL (NCT05659888)
- Where
- 13 sites in Netherlands
- Volunteers
- 827 people
- Sponsor
- Clinical Operations WCN B.V.
STEMI
NLR AND CRP Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction
Acute myocardial infarction (AMI) is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide.
- Trial name
- NCT06491667
- Testing
- CBC, C-reactive protein
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
STEMI
OCT Guided Magmaris RMS in STEMI
Percutaneous treatment of coronary artery disease depends on the implantation of stents within diseased coronary segments. Compared with conventional bare-metal and drug- eluting stents, which remain permanently within the…
- Trial name
- BESTMAG (NCT03955731)
- Testing
- Magmaris resorbable magnesium scaffold
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven