Clinical trials: ST-segment Elevation Myocardial Infarction
ST-segment Elevation Myocardial Infarction (STEMI)
Predictive Value of PRECISE DAPT Score in STEMI Patients After Primary PCI
To investigate the predictive value of PRECISE DAPT score in relation to coronary slow flow \& other short term major adverse cardiovascular events (MACE) post PPCI .
- Trial name
- NCT04549766
- Testing
- calculate PRECISE DAPT score using clinical data
- Volunteers
- 150 people
- Sponsor
- Assiut University
ST Segment Elevation Myocardial Infarction (STEMI), Allogeneic Mesenchymal Bone Marrow Cells
A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With ST Segment Elevation Myocardial Infarction (STEMI)
The purpose of this study is to assess the safety and tolerability of human allogeneic mesenchymal bone marrow cells (aMBMC) administered intravenously to subjects with ST Segment Elevation Myocardial Infarction (STEMI).
- Trial name
- NCT01770613
- Testing
- Stem cells
- Where
- 2 sites in United States
- Sponsor
- Stemedica Cell Technologies, Inc.
Non-ST-segment Elevation Myocardial Infarction
Study on High-sensitivity Troponin 0h/1h for Rapid Diagnosis of Non-ST-segment Elevation Myocardial Infarction in the Chinese Population
The purpose of the study is to establish a high-sensitivity troponin 0h/1h process for the diagnosis of patients suspected of NSTEMI for the Chinese population, obtain the inclusion and exclusion criteria for diagnosis of these…
- Trial name
- NCT03331549
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction
Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in Myocardial Infarction
This was a double-blind, randomized, placebo-controlled study that was designed to enroll a total of 225 participants with de novo anterior wall acute ST-segment elevation myocardial infarction (STEMI) due to a lesion of the left…
- Trial name
- AMICI (NCT01781390)
- Testing
- Mesenchymal Precursor Cells (MPC) 12.5 M, Mesenchymal Precursor Cells (MPC) 25 M
- Volunteers
- 106 people
- Sponsor
- Mesoblast, Inc.
ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention
Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction
This is a double-blind, multicenter, randomized, placebo-controlled clinical trial. It is planned to enroll patients admitted with anterior ST-segment elevation myocardial infarction (STEMI) within 6h of symptom onset and undergo…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, Cardioprotection
- Trial name
- COOPERATION (NCT04912518)
- Testing
- Dexmedetomidine (DEX)
- Where
- 9 sites in China
- Volunteers
- 250 people
- Sponsor
- Harbin Medical University
Ischemic Heart Disease, Myocardial Infarction
Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study
RITA-MI aims to develop of a novel therapeutic concept to target the immune response in patients with acute myocardial infarction (MI) by depleting B-cells with a single injection of Rituximab which is approved for clinical use…
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Inflammation
- Trial name
- RITA-MI (NCT03072199)
- Testing
- RiTUXimab Injection
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Angioplasty
Aspiration Device in Myocardial Infarction Trial
Early promising data are published focusing on the role of manual thrombus aspiration devices in patients with ST segment elevation (STEMI).
- Trial name
- NCT00370578
- Testing
- repeated thrombus aspiration during primary PCI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
STEMI
STENTYS Self-expanding Versus Balloon-expandable Stent in Acute Myocardial Infarction (AMI)
Study hypothesis: the Stentys self-expandable Stent results into a better alignment of the struts to the vessel wall than a balloon-expandable stent within a few days after the procedure in acute myocardial infarction patients.
- Trial name
- APPOSITION ll (NCT01008085)
- Testing
- Stentys coronary stent, Balloon-expandable stent
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Stentys
STEMI, Morphine
Methylnaltrexone as a Method to Improve Ticagrelor Uptake in Morphine Treated STEMI Patients
This study will examine the impact of the peripheral opioid antagonist methylnaltrexone on the onset of effect of ticagrelor in morphine treated patients with ST elevation myocardial infarction (STEMI).
- Conditions
- STEMI, Morphine, Ticagrelor, Methylnaltrexone
- Trial name
- MOVEMENT (NCT02942550)
- Testing
- Methylnaltrexone bromide (Relistor®)., Sodium Chloride 9mg/mL
- Where
- 2 sites in Sweden
- Volunteers
- 82 people
- Sponsor
- Karolinska University Hospital
ST Elevation Myocardial Infarction
Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure.
- Trial name
- REMOD-TEP (NCT02789098)
- Testing
- (15)-O water positron emission tomography and Biomarkers
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Acute Myocardial Infarction
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?
Rationale: A safety and dose defining study in which the investigators hypothesize that in patients with acute coronary syndrome without ST-elevation (NSTEMI) treatment with heme arginate results in better clinical outcome by…
- Trial name
- HAEM (NCT00483587)
- Testing
- Heme arginate
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Primary PCI - STEMI
STEMI Treated With Primary Angioplasty and Intravenous Lovenox or Unfractionated Heparin (UFH)
Randomized evaluation of enoxaparin (0.5mg/kg IV) versus UFH (50-70IU/kg with GPIIb/IIIa inhibitors; 70-100IU without GPIIb/IIIa inhibitors).
- Trial name
- ATOLL (NCT00718471)
- Testing
- Enoxaparin, UFH (unfractionated heparin)
- Where
- France
- Volunteers
- 910 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
STEMI
Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients
Methodology This study will enroll (120) patients presenting with acute anterior STEMI who will undergo early reperfusion presenting at Helwan University Hospitals and Ain Shams University Hospitals.
- Trial name
- NCT05957887
- Testing
- Dapagliflozin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mohamed Nabil Elkholy
ST Elevation Myocardial Infarction, Non ST Elevation Myocardial Infarction
Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry
The CLEAR SYNERGY trial will study the long term effects of treatments following PCI to treat myocardial infarction. These treatments address both the culprit artery (PCI with SYNERGY stent) as well as the non-culprit arteries…
- Trial name
- CLEAR SYNERGY (NCT03048825)
- Testing
- Colchicine, Spironolactone, SYNERGY Bioabsorbable Polymer Drug-Eluting Stent
- Where
- 109 sites in United States, Australia and 12 more
- Volunteers
- 7,264 people
- Sponsor
- Population Health Research Institute
Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
Safety of Accelerated Rule-out Protocols in Patients Admitted With Chest Pain to a Crowded Chest Pain Unit (CPU)
The aim of this observational study registry is to assess the safety of a Non-ST-elevation myocardial infarction (STEMI) rapid rule-out strategy as proposed by European Guidelines in patients presenting with suspected acute…
- Trial name
- NCT03111862
- Testing
- NSTEMI Rule-Out according to hs-TnT
- Where
- Germany
- Volunteers
- 3,567 people
- Sponsor
- University Hospital Heidelberg
STEMI
A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in STEMI
The PANACEA trial is an investigator-initiated prospective, single-center, two-arm, non-blinded pilot randomized controlled trial of high-dose IV N-Acetylcysteine therapy used as an adjunct to pharmaco-invasive reperfusion in…
- Trial name
- PANACEA (NCT04023266)
- Testing
- Intravenous N-Acetylcysteine
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Ischemic Heart Disease
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial
This trial will evaluate Orbital Atherectomy compared to conventional balloon angioplasty technique for the treatment of severely calcified lesions prior to implantation of drug-eluting stents (DES).
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
- Trial name
- ECLIPSE (NCT03108456)
- Testing
- Orbital Atherectomy, Balloon
- Where
- 104 sites in United States
- Volunteers
- 2,005 people
- Sponsor
- Abbott Medical Devices
Myocardial Infarction
Long Term Follow-up of Autologous Bone Marrow Mononuclear Cells Therapy in STEMI
The benefit of current reperfusion therapies for ST-elevation myocardial infarction (STEMI) is limited by post-infarction left ventricular (LV) dysfunction.
- Trial name
- NCT00626145
- Testing
- saline infusion, autologous bone marrow mononuclear cells infusion
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Xijing Hospital
Myocardial Reperfusion Injury
Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI
Percutaneous coronary intervention (PCI) for acute coronary syndromes frequently fails to restore myocardial perfusion despite establishing epicardial vessel patency.
- Trial name
- BQ-123 (NCT00586820)
- Testing
- BQ-123
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic