Clinical trials: ST-segment Elevation Myocardial Infarction (STEMI)
ST Elevation Myocardial Infarction (STEMI)
Effect of Very Early and Rapid Lowering Cholesterol With Evolocumab on Left Ventricular Remodeling in Patients With Anterior STEMI Undergoing Primary PCI
For patients with anterior ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), whether early application of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors to…
- Trial name
- EVALUATE-STEMI (NCT05613426)
- Testing
- Rosuvastatin 20 mg, Evolocumab 140 mg/1 ml Subcutaneous Solution [REPATHA]
- Where
- 6 sites in China
- Volunteers
- 119 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
ST Elevation Myocardial Infarction
Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction
GNR-060(JSC "GENERIUM", Russia) is a proposed biosimilar to the referent product Metalyse. This study is to compare the clinical efficacy and safety of GNR-060 vs Metalyse as a thrombolitic agent in patients with with ST…
- Trial name
- NCT05601999
- Testing
- GNR-060, Metalyse
- Where
- 11 sites in Russia
- Volunteers
- 244 people
- Sponsor
- AO GENERIUM
ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention
The investigators evaluate the efficacy and safety of intravenous administration of nicorandil as adjuncts to reperfusion treatment in acute ST-segment elevation acute myocardial infarction (STEMI) patients undergoing primary…
- Trial name
- CLEAN (NCT04665648)
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Fudan University
Non-ST-segment Elevation Myocardial Infarction
Study on High-sensitivity Troponin 0h/1h for Rapid Diagnosis of Non-ST-segment Elevation Myocardial Infarction in the Chinese Population
The purpose of the study is to establish a high-sensitivity troponin 0h/1h process for the diagnosis of patients suspected of NSTEMI for the Chinese population, obtain the inclusion and exclusion criteria for diagnosis of these…
- Trial name
- NCT03331549
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital
ST-elevation Myocardial Infarction
Cost-effectiveness of Remote Ischemic Conditioning as an Adjunct to Primary Percutaneous Coronary Intervention
The aim of this study is to investigate the cost-effectiveness of remote ischemic conditioning as an adjunct to primary percutaneous coronary intervention from the perspective of a Danish healthcare system.
- Trial name
- NCT02431338
- Testing
- Remote ischemic conditioning
- Where
- Denmark
- Volunteers
- 333 people
- Sponsor
- University of Aarhus
ST Elevation Acute Myocardial Infarction
COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial
Remote ischemic conditioning (RIC) and intravenous exenatide administered immediately before primary angioplasty have been found to limit infarct size in patients with STEMI (ST segment elevation myocardial infarction), but the…
- Trial name
- COMBAT-MI (NCT02404376)
- Testing
- Exenatide, Remote Ischemic Conditioning (RIC)
- Where
- 6 sites in Spain
- Volunteers
- 378 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Coronary Syndrome
A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects
This study will evaluate the relative efficacy and safety of prasugrel and clopidogrel in a medically managed Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) acute coronary syndrome (ACS) population (that is…
- Trial name
- TRILOGY ACS (NCT00699998)
- Testing
- Clopidogrel, Prasugrel, Commercially-available Aspirin
- Where
- 688 sites in United States, Argentina and 51 more
- Volunteers
- 9,326 people
- Sponsor
- Eli Lilly and Company
Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction
ST-elevation myocardial infarction (STEMI) is mostly caused by the rupture or the erosion of a vulnerable atherosclerotic plaque, initiating with intraluminal thrombosis and resulting in total occlusion of the coronary artery.
- Trial name
- NCT03731884
- Testing
- Time from the onset of symptoms to PCI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- G. d'Annunzio University
ST-segment Elevation Myocardial Infarction
EROSION II: OCT Guided PPCI in STEMI
This protocol describes a prospective, multi-center study intended to test the hypothesis that patients with STEMI caused by plaque rupture or plaque erosion without obstructive stenosis (diameter stenosis <70%) can be stabilized…
- Trial name
- NCT03062826
- Testing
- dual antiplatelet therapy (aspirin + ticagrelor or aspirin + clopidogrel)
- Where
- 16 sites in China
- Volunteers
- 347 people
- Sponsor
- Harbin Medical University
Myocardial Infarction
Trimethylamine N-oxide in Myocardial Infarction
Trimethylamine-N-oxide (TMAO) is produced from the metabolism of gut microbiota and is reportedly pro-atherogenic and associated with cardiovascular events.
- Trial name
- NCT03418285
- Volunteers
- 112 people
- Sponsor
- Yokohama City University Medical Center
STEMI, Covid19
Evaluation of the Effect of Long-term Lipid-lowering Therapy in STEMI Patients With Coronavirus Infection COVID-19
It is planned to include 200 patients hospitalized with primary myocardial infarction with and without ST segment elevation (STEMI or NSTEMI) in combination with COVID-19 within the first 15 days from the disease onset.
- Conditions
- STEMI, Covid19, NSTEMI
- Trial name
- CONTRAST-3 (NCT04900155)
- Testing
- Atorvastatin 80mg, Atorvastatin-Ezetimibe
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Penza State University
Acute Myocardial Infarction
Intracoronary Autologous Stem Cell Transplantation in ST Elevation Myocardial Infarction: TRACIA STUDY.
The purpose of this study is to evaluate the ejection fraction (EF) increase at 6 months follow up and major adverse cardiovascular events (MACE) after intracoronary autologous stem cell transplantation in ST elevation myocardial…
- Trial name
- TRACIA (NCT00725738)
- Testing
- Stem Cell Transplantation
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- National Heart Institute, Mexico
ST-elevation Myocardial Infarction (STEMI)
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI
This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the ambulance if they meet all eligibility criteria.
- Trial name
- CELEBRATE (NCT04825743)
- Testing
- zalunfiban
- Where
- 45 sites in United States, Canada and 6 more
- Volunteers
- 2,463 people
- Sponsor
- CeleCor Therapeutics
ST Elevation (STEMI) Myocardial Infarction
Bempedoic Acid in PPCI Impact on Clinical Outcome and Inflammatory Markers
Bempedoic acid in PPCI
- Trial name
- NCT07129850
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stable Angina, Unstable Angina
Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography
The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.
- Conditions
- Stable Angina, Unstable Angina, Non ST Segment Elevation Myocardial Infarction, Post MI
- Trial name
- NCT02070679
- Testing
- Vitamin E
- Where
- 2 sites in Iran
- Volunteers
- 284 people
- Sponsor
- Urmia University of Medical Sciences
Coronary Artery Diseases
BIOTRONIK - BIOFLOW-III Registry French Satellite
For the majority of Coronary Artery Disease (CAD) treatment with Percutaneous Transluminal Coronary Angioplasty (PTCA) provides high initial procedure success.
- Trial name
- NCT02273648
- Testing
- Drug Eluting Stent (DES)
- Where
- 50 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Biotronik France
Multivessel Coronary Artery Disease, STEMI
The Use Of FFR Guided PCI Versus Complete Revascularization and Treatment Of Infarct Related Artery Only In Patients With STEMI
In patients with ST elevation myocardial infarction (STEMI) the treatment goal is revascularization of the occluded artery with the use of primary percutaneous coronary intervention (PCI).
- Conditions
- Multivessel Coronary Artery Disease, STEMI, FFR Guided PCI
- Trial name
- FAIO (NCT02637440)
- Testing
- FFR guided PCI, Angio guided PCI
- Where
- 2 sites in Ireland
- Volunteers
- 560 people
- Sponsor
- University of Limerick
ST-Elevation Myocardial Infarction, Acute Coronary Syndrome
European Registry on STEMI Patients Transferred for PCI With Upstream Use of Abciximab - EuroTransfer Registry
EUROTRANSFER Registry is a prospective, international, web-based European Registry on Patients with ST-Elevation MI Transferred for Mechanical Reperfusion (PCI) with a Special Focus on Upstream Use of Abciximab.
- Trial name
- NCT00378391
- Where
- 15 sites in Finland, Germany and 5 more
- Volunteers
- 1,800 people
- Sponsor
- Jagiellonian University
Myocardial Infarction
Routine Angioplasty and Stenting After Fibrinolysis for Acute Myocardial Infarction
Background: In Canada, most patients with acute myocardial infarction (AMI) present to hospitals without cardiac catheterization facilities. Thrombolytic therapy remains the standard-of-care in these centres.
- Trial name
- NCT00164190
- Testing
- Routine Early Percutaneous Coronary Intervention after Thrombolysis
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Canadian Heart Research Centre
ST Segment Elevation Myocardial Infarction
DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction
This study focuses on Cardioprotective strategies.
- Trial name
- DANAMI-3 (NCT01435408)
- Testing
- Conventional primary PCI, Ischemic postconditioning., Deferred stenting in primary PCI.
- Where
- 5 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet