Clinical trials: STEMI - ST Elevation Myocardial Infarction
ST Elevation Myocardial Infarction
Dutogliptin in Co-administration With Filgrastim in Early Recovery Post-myocardial Infarction
The goal of this phase 3, randomized, double-blind, placebo-controlled clinical trial is to explore the safety and efficacy of dutogliptin administered subcutaneously (SC) in co-administration with filgrastim in adult patients…
- Trial name
- HEAL-MI (NCT05881382)
- Testing
- Dutogliptin + Filgrastim
- Volunteers
- 4,100 people
- Sponsor
- Recardio, Inc.
ST Segment Elevation Myocardial Infarction (STEMI), No Reflow Phenomenon
The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow
The aim of this work is to study the role of intracoronary adrenaline administration as a preventive tool for no reflow in patients undergoing primary PCI.
- Trial name
- NCT06847568
- Testing
- Adrenaline
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- Ain Shams University
Distal Radial Artery Approach, ST Elevation Myocardial Infarction
Comparison of Success Rate Between Distal Radial Approach and Radial Approach in STEMI
ST-segment elevation myocardial infarction (STEMI) is an emergent disease to treat as soon as possible. 2017 ESC guidelines for the management of STEMI recommend using radial approach (RA) rather than femoral approach (FA) to…
- Trial name
- NCT03611725
- Testing
- Distal radial artery, Radial artery
- Where
- 3 sites in South Korea
- Volunteers
- 352 people
- Sponsor
- Wonju Severance Christian Hospital
Non-ST Elevated Myocardial Infarction, Electrocardiography
Clinical Characteristics, Treatments, and Outcomes of MI Patients Presenting With Normal ECG
the investigators aimed to analyzed data for hospitalized MI patients with normal ECG.
- Trial name
- NCT04710446
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Henan Provincial People's Hospital
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
STEMI
CMR Repeatability in STEMI
The investigators propose to conduct a study to measure the reproducibility of CMR parameters that have been used to predict outcome following PPCI: infarct size, left ventricular volumes, myocardial salvage, microvascular…
- Trial name
- NCT01468662
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Bristol
Myocardial Infarction
Myocardial Salvage and Contrast Dye Induced Nephropathy Reduction by N-Acetylcystein
Acetylcystein is a potent antioxidans which is able to prevent contrast dye induced nephropathy in stable patients undergoing additional hydration. In primary percutaneous intervention for infarction hydration is not possible.
- Trial name
- LIPSIA-N-ACC (NCT00463749)
- Testing
- Acetylcystein
- Where
- Germany
- Volunteers
- 251 people
- Sponsor
- University of Leipzig
Neutrophils.Hypersegmented | Bld-Ser-Plas, STEMI - ST Elevation Myocardial Infarction
CLEAR SYNERGY Neutrophil Substudy
CLEAR SYNERGY is an international multi center 2x2 randomized placebo controlled trial of colchicine and spironolactone in patients with STEMI.
- Trial name
- NCT03874338
- Testing
- Colchicine Pill
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- NYU Langone Health
Cardiovascular Diseases
Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction
The 'no-reflow' phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- and long-term mortality.
- Trial name
- NCT02798874
- Testing
- Ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
An Epidemiological Cohort Study of Acute Coronary Syndromes in The Greek Population. The PHAETHON Study
A nationwide registry of patients with acute coronary disease to evaluate epidemiological patient characteristics, medical management, implementation of invasive strategy, patient outcome and impact on quality of life in Greece.
- Trial name
- PHAETHON (NCT02420808)
- Where
- Greece
- Volunteers
- 800 people
- Sponsor
- Hellenic Cardiovascular Research Society
STEMI, CAD
Remote Ischemic Conditioning in STEMI to Decrease Infarct Size
Following acute STEMI patients may have significant myocardial damage and subsequent heart failure. There is currently conflicting data regarding the benefit of remote ischemic conditioning to decrease the magnitude of…
- Trial name
- RemCon-STEMI (NCT03930589)
- Testing
- Remote Ischemic conditioning, Standard of care
- Volunteers
- 251 people
- Sponsor
- University of Alberta
Myocardial Infarction, Myocardial Ischemia
Time for a Paradigm Shift: STEMI/NSTEMI to OMI/NOMI ?
The current ST-segment elevation (STEMI)/non-STEMI treatment paradigm misses nearly one fourth of acute coronary occlusions (ACO) that needs immediately reperfusion.
- Trial name
- DIFOCCULT-2 (NCT05705102)
- Testing
- Coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people
- Sponsor
- Marmara University
ST Elevation Myocardial Infarction
Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
This is a prospective, randomized, double-blind, double-dummy, and controlled clinical study over a total of 4-week therapy with DLBS1033 in the management of STE-ACS after a primary PCI.
- Trial name
- NCT02976701
- Testing
- DLBS1033, Standard therapy
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Dexa Medica Group
CONUT Score, ST Elevation (STEMI) Myocardial Infarction
Association of Prognostic Nutritional Index and Controlling Nutritional Status Score With ST Elevation Myocardial Infarction
It is well known that malnutrition is a prognostic risk factor in chronic heart failure (CHF). Weight loss and the development of cardiac cachexia are associated with poor prognosis in CHF.
- Conditions
- CONUT Score, ST Elevation (STEMI) Myocardial Infarction, Mortality
- Trial name
- NCT07369037
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Muğla Sıtkı Koçman University
ST Elevation Myocardial Infarction (STEMI), Acute Coronary Syndromes (ACS)
A Single-Center, Retrospective, Propensity-Score-Matched Cohort Study Comparing Drug-Coated Balloon Versus Drug-Eluting Stent for Reducing Immediate Post-Procedural Slow-Flow/No-Reflow in Acute ST-Elevation Myocardial Infarction Patients With High Thrombus Burden
This is a single-center, retrospective, propensity-score-matched observational study. It aims to compare the rate of immediate slow-flow or no-reflow after percutaneous coronary intervention (PCI) between drug-coated balloon…
- Trial name
- STEMI-DCB (NCT07806370)
- Testing
- Drug-Coated Balloon (DCB), Drug-Eluting Stent (DES)
- Where
- China
- Volunteers
- 668 people
- Sponsor
- Xijing Hospital
Myocardial Infarction
Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMI
The primary goal To assess the effect of atorvastatin in patients treated since the first 24-96 hours of the disease on the parameters of global and regional myocardial deformation in the infarcted area and the structural and…
- Trial name
- CONTRAST (NCT02590653)
- Testing
- Atorvastatin
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Penza State University
Myocardial Infarction
Complete Lesion Versus Culprit Lesion Revascularization
To investigate the clinical outcomes of acute myocardial infarction (AMI) patients with multivessel disease undergoing percutaneous coronary intervention (PCI) either in infarct-related artery only or in multivessel in Drug…
- Trial name
- COCUA (NCT01180218)
- Testing
- complete revascularization, Culprit revasularization
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel
The administration of these drugs is realized according to the European Society of Cardiology guidelines. All patients will be pretreated with aspirin 300 mg orally, heparin iv to maintain an activated clotting time of >250 sec…
- Conditions
- Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032290
- Testing
- Assessment of Coronary Flow Reserve, Percutaneous coronary intervention, ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive Symptoms
Brief Summary: The aim of this study is to explore the initial feasibility and acceptability of (a) Mindfulness-Based Cognitive Therapy (MBCT) adapted for ACS patients; (b) the group videoconferencing delivery medium; and (c)…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT04231097
- Testing
- MBCT intervention for ACS patients
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Atherosclerotic Cardiovascular Disease, STEMI
Real Life Lipid Management in Hospitals Not Participating in PENELOPE Trial - Control Population for PENELOPE
Guideline recommended evidence-based clinical care correlates with improved patient outcomes. In real life care, however, adherence to guideline recommendations remains suboptimal.
- Conditions
- Atherosclerotic Cardiovascular Disease, STEMI, Non STEMI
- Trial name
- PENELOPECTRL (NCT05659888)
- Where
- 13 sites in Netherlands
- Volunteers
- 827 people
- Sponsor
- Clinical Operations WCN B.V.