Clinical trials: Sacral Neuromodulation
Overactive Bladder Syndrome, Urinary Retention
OptiLUTS Part C: the Development of a Symptom Assessment Tool in Sacral Neuromodulation.
Sacral neuromodulation (SNM) is a two-staged 2nd-line therapy for therapy-resistant LUTS and fecal incontinence. Currently, the assessment of symptoms at baseline and after stage I is directed towards a discipline related…
- Conditions
- Overactive Bladder Syndrome, Urinary Retention, Dysfunctional Voiding, Fecal Incontinence
- Trial name
- OptiLUTS (NCT05313984)
- Testing
- Sacral neuromodulation
- Where
- Belgium
- Volunteers
- 93 people
- Sponsor
- University Hospital, Ghent
Overactive Bladder (OAB)
INOPASE - Performance and Safety Study of a Personalised SNM System
The goal of this clinical trial is to learn whether a new sacral neuromodulation (SNM) system (INO-SNM-01) can safely and effectively sense bladder nerve activity and provide stimulation to help manage symptoms of refractory…
- Trial name
- NCT07193407
- Testing
- Sacral Neuromodulation System
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- INOPASE Pty Ltd
Overactive Bladder, Non-obstructive Urinary Retention
Sacral Neuromodulation & Urodynamics
In the field of urology, sacral neuromodulation (SNM) is a well-accepted, second-line, minimally invasive treatment for patients with overactive bladder dry (OABD) or wet (OABW), and for patients with non-obstructive urinary…
- Trial name
- NCT03614767
- Testing
- urodynamics
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universiteit Antwerpen
Detrusor Overactivity
UNGF Assessment in Patients With Detrusor Overactivity Undergoing Sacral Neuromodulation
The purpose of this study is to find a noninvasive test to help physicians diagnose detrusor overactivity (DO), to use this urine test to help diagnose bladder problems, determine if treatments are working, and determine if…
- Trial name
- NCT01850706
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Urinary Incontinence, Urge
Sacral Nerve Stimulation to Treat Urgency Urinary Incontinence With Wireless Neuromodulation
The purpose of this pivotal study is to illustrate the safety and effectiveness of the StimGuard Sacral Nerve Stimulation (SNS) System in the treatment refractory urge incontinence.
- Trial name
- NCT02434874
- Testing
- StimGuard Sacral Nerve Stimulator System
- Where
- United States
- Sponsor
- Uro Medical Corporation
Rechargeable Sacral Neuromodulation Device, Neurogenic Lower Urinary Tract Dysfunction
Cost Profile and Budget Implications of Rechargeable Versus Non-rechargeable Sacral Neuromodulation Devices for Neurogenic Lower Urinary Tract Dysfunction
Traditional sacral neuromodulation devices are not rechargeable. In recent years, new rechargeable sacral neuromodulation devices have been developed and put into the market.
- Trial name
- SNM、NLUTD (NCT07173517)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Qilu Hospital of Shandong University
Refractory Neurogenic LUTD
Sacral Neuromodulation for Neurogenic LUT Dysfunction
Prospective, randomized, placebo-controlled, double-blind multicenter trial including 4 tertiary sacral neuromodulation referral centers in Switzerland (Zürich, Bern, Nottwil, St.Gallen).
- Trial name
- NCT02165774
- Testing
- Turning OFF the neuromodulator, Turning ON the neuromodulator
- Where
- 4 sites in Switzerland
- Volunteers
- 61 people
- Sponsor
- University of Zurich
Cystometry, Sacral Neuromodulation
Efficacy of Sacral Nerve Modulation on Urinary and Defecation Dysfunction After Spinal Cord Injury：A Prospective, Single-arm Study
The aim of this study is to investigate the long-term efficacy of sacral nerve modulation surgery in the treatment of neurogenic lower urinary tract dysfunction caused by incomplete spinal cord injury, as well as its preventive…
- Conditions
- Cystometry, Sacral Neuromodulation, Ultrasound
- Trial name
- NCT06553469
- Testing
- sacral neuromodulation
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Qilu Hospital of Shandong University
Urinary Retention
Efficacy of Electrical Pudendal Nerve Stimulation and Sacral in Treating Non-obstructive Neurogenic Urinary Retention
To observe the clinical effects and make a comparative study between efficacy of electrical pudendal nerve stimulation (EPNS) and sacral neuromodulation (SNM) , evaluate the advantages of EPNS in the treatment of neurogenic…
- Trial name
- NCT06158074
- Testing
- electrical pudendal nerve stimulation, sacral neuromodulation
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Overactive Bladder
Clinical and Urodynamic Predictors for Sacral Neuromodulation Outcomes in Overactive Bladder
Overactive bladder syndrome (OAB) is a prevalent disorder that affects about 10% of the adult population and > 40% of elderly. It is defined by the presence of urgency, with or without urge incontinence, in the absence of…
- Trial name
- NCT03156088
- Testing
- Sacral Neuromodulator "InterStim"
- Volunteers
- 100 people
- Sponsor
- Assiut University
Endometriosis
Sacral Neuromodulation for Pelvic Pain Associated With Endometriosis
The purpose of this study is to find out if sacral neuromodulation is an effective treatment for pelvic pain associated with surgically treated endometriosis.
- Trial name
- NCT03139734
- Testing
- Sacral Neuromodulation
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Seinajoki Central Hospital
Constipation, Surgery
Effectiveness and Safety of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation
Rationale: Previous reviews showed that the evidence regarding the effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant, idiopathic (slow-transit) constipation is of suboptimal quality.
- Trial name
- NCT02961465
- Testing
- Sacral Neuromodulation
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht University Medical Center
Neurogenic Bladder, Neurogenic Bowel
Sacral Neuromodulation in Neurogenic Patients
The goal of this observational study is to evaluate efficacy and safety of sacral neuromodulation in neurogenic patients compared to non-neurogenic (idiopathic) patients. [.
- Conditions
- Neurogenic Bladder, Neurogenic Bowel, Urge Incontinence, Overactive Bladder
- Trial name
- NCT05688644
- Testing
- InterStim II
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Omri Schwarztuch Gildor
Urinary Incontinence, Urge
Refractory Overactive Bladder: Sacral NEuromodulation v. BoTulinum Toxin Assessment (ROSETTA)
The purpose of this randomized, open-label, active-control trial is to compare the effectiveness of intra-detrusor botulinum toxin A (Botox A®, Allergan) versus sacral neuromodulation (InterStim®, Medtronic) for the treatment of…
- Trial name
- ROSETTA (NCT01502956)
- Testing
- InterStim® device, Botox® injection
- Where
- 9 sites in United States
- Volunteers
- 386 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Overactive Bladder, Non Obstructive Urinary Retention
Time of Effect Onset in Treating Overactive Bladder or Non Obstructive Urinary Retention by Sacral Neuromodulation
Sacral neuromodulation (SNM) is a minimally invasive secondary treatment for overactive bladder syndrome (OAB) or for non-obstructive urinary retention (NOR), when refractory to conservative treatment.
- Trial name
- NCT02040519
- Testing
- Filling out voiding diaries.
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Maastricht University Medical Center
Urinary Incontinence, Urge
Axonics SacRal NeuromodulaTIon System for Urinary Urgency Incontinence TreatmeNt
The ARTISAN-SNM study is designed to evaluate the safety and effectiveness of the Axonics Sacral Neuromodulation System as an aid in the treatment of the symptoms of urinary urgency incontinence (UUI) in patients who have failed…
- Trial name
- ARTISAN-SNM (NCT03327948)
- Testing
- Axonics Sacral Neuromodulation System (SNM) System
- Where
- 4 sites in United States, Netherlands and 1 more
- Volunteers
- 129 people
- Sponsor
- Axonics, Inc.
Faecal Incontinence
Best Surgical Technique for Optimal Lead Placement in Sacral Neuromodulation - a Comparative Cadaver Study
Sacral neuromodulation (SNM) is an established treatment option for patients with faecal incontinence. The location of the stimulating electrode is considered to be essential for treatment success.
- Trial name
- NCT04726904
- Testing
- Sacral neuromodulation in conventional implantation technique
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Rectal Cancer, for Bowel Dysfunction Following Surgery for Rectal Cancers
Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for Rectal Cancers With Sphincter Preservation
The purpose of this study is to evaluate whether a medical device/implant (InterStimTM) will help patients to have more normal bowel movements. The InterStimTM device is a neuromodulating device.
- Trial name
- NCT02163187
- Testing
- Implantation of the InterStimTM, MSK BFI questionnaires, The Low Anterior Resection Score (LARS) questionnaires
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Overactive Bladder Syndrome, Urinary Urge Incontinence
Cycling Study With the Axonics System
A prospective, multi-center, study comparing continuous sacral neuromodulation (SNM) stimulation to daily cyclic stimulation of 2 hours "on" and 22 hours "off" using the Axonics System.
- Conditions
- Overactive Bladder Syndrome, Urinary Urge Incontinence, Sacral Neuromodulation
- Trial name
- NCT05543382
- Testing
- Axonics System
- Where
- 6 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Axonics, Inc.
Interstitial Cystitis
Sacral Neuromodulation in Patients With IC
The hypothesis for this study is that bilateral sacral neuromodulation will improve symptoms of interstitial cystitis by at least 25% when compared to unilateral sacral neuromodulation as reported by patient's responses to the…
- Trial name
- NCT00590473
- Testing
- Interstim
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Drexel University College of Medicine