Clinical trials: Sadness
Healthy Volunteers
FiH Study to Assess Safety and PK of SAD and MAD of ANT3310 Alone and in Combination With Meropenem in Healthy Subjects
The purpose of this study is to evaluate the safety and tolerability of single and multiple intravenous ascending doses of ANT3310, a novel, specific, competitive inhibitor of serine β-lactamases, alone and in combination with…
- Trial name
- NCT05905913
- Testing
- ANT3310, Meropenem
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Antabio
COPD, Anxiety
Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)
Objective: Determine whether treatment of perceived stress, anxiety, and depression with anti-depressant therapy improves dyspnea scores, 6-minute walk (6MW) distance and quality of life (QoL) in patients with Chronic Obstructive…
- Conditions
- COPD, Anxiety, Depression, Stress
- Trial name
- SAD-COPD (NCT02813447)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
IPF
A Study to Evaluate the Safety, Tolerability, PK and PD of HNC1058
The purpose of this First-in-Human study is to evaluate the safety and tolerability after single ascending oral doses of HNC1058 given to healthy subjects, compared to placebo.
- Trial name
- NCT05803850
- Testing
- HNC1058 Capsules
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
Social Anxiety Disorder (SAD), Autistic Disorder
Autism Traits in Adolescents With Social Anxiety Disorder: Associations With Parental Broader Autism Phenotype
This observational study aims to examine autism-related traits in adolescents diagnosed with social anxiety disorder (SAD) and to evaluate their associations with broader autism phenotype (BAP) features in their parents.
- Trial name
- NCT07106840
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Ankara City Hospital Bilkent
Seasonal Affective Disorder
Bright Light Therapy in Seasonal Affective Disorder (SAD)
The aim of this study is to investigate the efficacy of bright light therapy in SAD. This is a placebo-controlled, double-blind randomized controlled trial (RCT).
- Trial name
- VAHAVA (NCT01030276)
- Testing
- Bright light therapy
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- University of Oulu
Sadness
Psychophysiological Effects of Birdsongs VS Music
The main goal of this study is to learn the psychophysiological effects of birdsongs on sadness. The main questions it aims to answer are: 1. Can birdsongs alleviate sadness in a short term? 2.
- Trial name
- NCT06581445
- Testing
- Birdsongs, Music
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Skin Disease, Immune System Disease
A Study of HL40626S Tablets in Healthy Adults
This is a single-centre, randomized, double-blind, placebo-controlled Phase 1 study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of HL40626S tablets following single and…
- Conditions
- Skin Disease, Immune System Disease, Skin Diseases, Papulosquamous, Psoriasis (PsO)
- Trial name
- NCT07736586
- Testing
- HL40626S tablets
- Where
- 2 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- HighsLab Therapeutics Inc.
Sadness
Swimming Immediately After Having a Meal
Many believe that it is unsafe to swim immediately after having a meal and that it is preferable to wait at least 30 minutes. The fear is that swimming can cause stomach cramps and muscle cramps with discomfort and potentially…
- Trial name
- NCT05401396
- Testing
- Swimming immediately after eating
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Diabete Mellitus
A Randomized, Double-blind, Placebo-controlled, Sequential Single and Multiple Ascending Doses of YG1699
This is a randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics (PK) of YG1699 following single and multiple ascending oral dose administration.
- Trial name
- NCT03953092
- Testing
- YG1699
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Youngene Therapeutics Inc., Ltd.
Healthy Volunteers
A Phase I Study Comparing the Safety, Pharmacokinetics and Renal Effects of VRP-034 and Marketed Polymyxin B in Healthy Volunteers
This is a Phase 1, single-center, randomized, double-blind, active-controlled clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and nephrotoxicity attenuation potential of VRP-034 compared with…
- Trial name
- VRP-034 (NCT07502144)
- Testing
- VRP-034 (Polymyxin B 500,000 IU), Commercially available Polymyxin B 500,000 IU (Poly-MxB)
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Venus Remedies Limited
Healthy Volunteers, Sickle Cell Disease
A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients
FT-4202 is an oral small-molecule agonist of pyruvate kinase red blood cell isozyme (PKR) being developed for the treatment of hemolytic anemias.
- Trial name
- NCT03815695
- Where
- 18 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Forma Therapeutics, Inc.
Alzheimer Dementia, Alzheimer Disease
SAD Phase I Study (First-in-human) to Investigate Contraloid Acetate
This is a single-center first-in-human single-ascending-dose clinical trial assessing the safety and tolerability of oral dosing of Contraloid acetate in healthy volunteers.
- Trial name
- NCT03944460
- Testing
- Contraloid
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Dieter Willbold
Used in Patients Receiving Anticoagulant Therapy (e.g., Rivaroxaban or Apixaban, Inhibitors of Coagulation Factor Xa) Who Require Reversal of Anticoagulation
Phase I Study of MT1011 Injection in Healthy Subjects
This is a single-center, randomized,double-blind, placebo-controlled Phase I study to evaluate safety, PK and PD of single ascending dose (SAD) of MT1011 injection in healthy adult subjects.
- Trial name
- NCT07024160
- Testing
- MT1011
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shaanxi Micot Pharmaceutical Technology Co., Ltd.
Healthy Volunteers
VNRX-7145 SAD/MAD Safety and PK in Healthy Adult Volunteers
This is a 2-part, first-in-human dose-ranging study to evaluate the safety and pharmacokinetics of escalating doses of VNRX-7145.
- Trial name
- NCT04243863
- Testing
- VNRX-7145
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Seasonal Affective Disorder, Vitamin D3
The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff
The purpose of this study is to investigate whether vitamin D3 (70 micrograms) is better than placebo in preventing depression symptoms among employees in health care
- Conditions
- Seasonal Affective Disorder, Vitamin D3, Mental Health, Dietary Supplement
- Trial name
- D3-vit-SAD (NCT01462058)
- Testing
- Vitamin D3
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Connie Thuree Nielsen, consultant, MD, ph.d
Safety Issues, Tolerability
Single Ascending Dose and Multiple Ascending Dose Study of AVR-48
This is a Phase 1 (healthy adult volunteers), 2-part, double-blind, randomized, placebo controlled trial to evaluate the safety and pharmacokinetic (PK) profiles of escalating single doses of AVR-48 versus placebo (SAD) and…
- Conditions
- Safety Issues, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06847698
- Testing
- AVR-48
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AyuVis Research, Inc.
Colonic Diseases
A Clinical Phase I Study on GIC-1001 in Healthy Volunteers
The objectives of this single center, randomized, double-blinded, placebo-controlled Phase I clinical study are to evaluate the safety and tolerability of five (5) single and four (4) multiple increasing oral doses of GIC-1001…
- Trial name
- NCT01738425
- Testing
- GIC-1001; 125 mg oral tablets
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- gicare Pharma Inc.
Ulcerative Colitis
SAD/MAD Study in Healthy Subjects and Adults With UC to Evaluate Safety, Tolerability, PK, PD of AMT-101
A randomized, double-blind placebo-controlled first in human study in approximately 36 male healthy subjects and approximately 20 male and female patients with active UC who have had an inadequate response to or demonstrated…
- Trial name
- AURIGA1 (NCT04224857)
- Testing
- AMT-101
- Where
- 4 sites in Georgia, Germany and 2 more
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Applied Molecular Transport
Childbirth-related PTSD, PTSD
International Survey of Childbirth-Related Trauma - Swedish Part
The goal of this cross-sectional observational study is to analyze childbirth-related PTSD, traumatic birth experiences and stress symptoms postpartum.
- Conditions
- Childbirth-related PTSD, PTSD, Postnatal Depression, Fear of Childbirth
- Trial name
- SwIntersect (NCT06207916)
- Where
- Sweden
- Volunteers
- 619 people
- Sponsor
- Region Östergötland
Social Anxiety
Arousal Training for Social Anxiety Disorder
The primary objective of the study is to examine the safety, usability and preliminary efficacy of a novel arousal-based biofeedback system in alleviating social anxiety.
- Trial name
- NCT02493010
- Testing
- Arousal-based biofeedback system
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School