Clinical trials: Safety Issues, open to volunteers
Reproductive Issues
The Efficacy and Safety of Female PRP Co-incubation With Sperm During (IUI) Cycles
The investigators hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.
- Trial name
- NCT07615634
- Testing
- non-PRP group (control group), PRP group (intervention group)
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Chinese University of Hong Kong
Reproductive Issues, Male Infertility
Efficacy and Safety of a New Sperm Capacitation Method
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various…
- Conditions
- Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia
- Trial name
- HyperSperm01 (NCT06742437)
- Testing
- Standard sperm preparation, HyperSperm
- Where
- 4 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fecundis Lab SL
Firearm Injury, Safety Issues
Pediatric Trauma Centers RE-AIM at Gun Safety
Universal firearm injury and violence prevention counseling of parents and patients has been recommended by multiple national organizations for over a decade, yet clinicians rarely deliver this counseling.
- Trial name
- ACTFAST (NCT06123611)
- Testing
- Adopting Comprehensive Training for FireArm Safety in Trauma centers
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Johns Hopkins University
Firearm Injury, Safety Issues
Adult Trauma Centers RE-AIM at Gun Safety
The goal of this interventional study is to evaluate the implementation and effectiveness of a comprehensive a universal firearm injury prevention program, ACTFAST (Adopting Comprehensive Training for FireArm Safety in Trauma…
- Trial name
- ACTFAST (NCT06302452)
- Testing
- Adopting Comprehensive Training for FireArm Safety in Trauma Centers
- Where
- 3 sites in United States
- Volunteers
- 1,776 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Reproductive Issues
Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Husband's Sperm
Hypotheses: We hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.
- Trial name
- NCT07282327
- Testing
- Female PRP co-incubation with husband's sperm in the IUI
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Chinese University of Hong Kong
Thromboembolic Disease, Lower Extremity Problem
The Safety and Efficiency of Endovascular Treatment of Acute or Subacute Thromboembolic Occlusions of Lower Extremity.
Based on the development of new tools, including drug coated balloon, paclitaxel eluting stent, interwoven stents, debulking tools, More and more acute or subacute thromboembolic occlusions of lower extremity included stage IIb…
- Conditions
- Thromboembolic Disease, Lower Extremity Problem, Endovascular Treatment, Safety Issues
- Trial name
- NCT04861506
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First People's Hospital of Hangzhou
Safety Issues, Efficacy, Self
Lower Silesia Culotte Bifurcation Registry (LSCBR).
The study aimed to evaluate the outcomes of bifurcation PCI using two techniques (Culotte vs. DK-Culotte) using data from a retrospective analysis.
- Trial name
- LSCBR (NCT06284057)
- Testing
- Bifurcation PCI with two stent technique Culotte Technique or Double Kiss (DK) Culotte
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Patient Satisfaction, Drug Adherence
Tenofovir Alafenamide Switch Therapy in Chronic Hepatitis B
Chronic hepatitis B (CHB) patients may be unsatisfied to entecavir (ETV) therapy due to the inconvenience in drug taking, i.e., fasting for more than 2 hours and/or dose adjustment according to estimated glomerular filtration…
- Conditions
- Patient Satisfaction, Drug Adherence, Efficacy, Self, Safety Issues
- Trial name
- NCT05583006
- Testing
- tenofovir alafenamide (TAF)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Bone Regeneration, Safety Issues
Evaluation of Performance, Safety and Benefit of the Wishbone HA as Bone Graft Substitute, a Pre-market Clinical Investigation
This investigation is a pre-market, prospective, multi-center, randomized, single blinded, parallel controlled clinical investigation performed in at least 5 clinical centers for confirmatory purposes of the use of WHA as…
- Trial name
- NCT06383377
- Testing
- Tooth extraction and bone graft procedure
- Where
- 5 sites in Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Wishbone SA
Safety Issues, Tolerance
Study to Evaluate LPH-5 in Healthy Subjects
This study will explore the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of LPH-5.
- Trial name
- NCT06722820
- Testing
- LPH-5
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Lophora
Safety Issues
Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever
This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT04270786
- Testing
- Early de-escalation, Standard
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Safety Issues, Efficacy, Self
Lower Silesian Orbital Atherectomy Registry (LOAR)
The Lower Silesian Orbital Atherectomy Registry (LOAR), is an observational registry collecting all consecutive cases of percutaneous coronary intervention (PCI) performed with the support of the Orbital Atherectomy Device due to…
- Trial name
- LOAR (NCT06451146)
- Testing
- PCI Facilitated with Orbital Atherectomy Device
- Where
- 2 sites in Poland
- Volunteers
- 500 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Effects of Chemotherapy, Safety Issues
Polatuzumab Vedotin and Zanubrutinib Plus R-CHP for Patients With Newly Diagnosed Untreated Non-GCB DLBCL
Aim of this study will evaluate the efficacy and safety of Polatuzumab Vedotin and Zanubrutinib in combination with R-CHP for newly diagnosed untreated Non-GCB DLBCL Patients with extranodal involvement.
- Trial name
- NCT06468943
- Testing
- Polatuzumab Vedotin, Zanubrutinib, Rituximab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Safety Issues
Safety, Tolerability, PK and PD of SSS55 in Healthy Subjects
This study was a single-dose, randomized, double-blind, placebo-controlled study of SSS55 injection to evaluate the safety, tolerability, PK characteristics, immunogenicity and preliminary efficacy characteristics of single-dose…
- Trial name
- NCT07058779
- Testing
- SSS55
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Safety Issues, Feasibility
A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent form of dementia, affecting 3-4% of the population over a lifetime. It's characterized by abnormal Amyloid-beta (Aβ) and tau protein expression and accumulation in the central…
- Conditions
- Safety Issues, Feasibility, Therapeutic Value
- Trial name
- NCT06448442
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Firearm Injury, Safety Issues
BeSMART Secure Storage Counseling in the Inpatient Setting
Firearm injuries are the leading cause of death for American youth. While most of these deaths are homicides, approximately one third are suicides and 5% are unintentional shootings where a child gains access to an unsecured…
- Trial name
- BeSMART (NCT06485141)
- Testing
- Safe Storage Intervention, Safe Kids Medication
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Safety Issues, Tolerability
Single Ascending Dose and Multiple Ascending Dose Study of AVR-48
This is a Phase 1 (healthy adult volunteers), 2-part, double-blind, randomized, placebo controlled trial to evaluate the safety and pharmacokinetic (PK) profiles of escalating single doses of AVR-48 versus placebo (SAD) and…
- Conditions
- Safety Issues, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06847698
- Testing
- AVR-48
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AyuVis Research, Inc.
Social Functioning, Addiction, Substance
Pain Clinic Provides Public Health Safety
Chronic pain is associated with psychological disorders; which may affect a patient's socioeconomic, legal, domestic, and employment situations.
- Conditions
- Social Functioning, Addiction, Substance, Safety Issues, Road Injury
- Trial name
- NCT06076512
- Testing
- Behavioral therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Safety Issues, Efficacy, Self
The Lower Silesia Shockwave Registry
Lower Silesia Shockwave Registry (LSSR), is a observational registry collecting all consecutive cases of percutaneous coronary intervention (PCI) performed with the support of shockwave intravascular lithotripsy in two…
- Trial name
- LSSR (NCT05916898)
- Testing
- PCI with support of Shockwave Intravascular Lithotripsy
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Miedziowe Centrum Zdrowia SA