Clinical trials: Saline
Knee Osteoarthritis
Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee
The purpose of this study is to determine the safety and effectiveness of micronized dehydrated human amnion chorion membrane as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee…
- Trial name
- NCT03485157
- Testing
- Micronized dHACM, Saline
- Where
- 17 sites in United States
- Volunteers
- 447 people
- Sponsor
- MiMedx Group, Inc.
Colon Mucous, Colonoscopy
Dose the Saline Reduce the Mucus Production When Water Exchange Colonoscopy is Used?
This is a study to compare the left colon mucus production between carbon dioxide (CO2) insufflation and water exchange (WE) colonoscopy in patients that require a routine or repeat colonoscopy.
- Trial name
- NCT04769739
- Testing
- CO2, Water, 50% saline
- Where
- Taiwan
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Preoperative Skin Preparation
Evaluation of the Antimicrobial Effectiveness of an Antimicrobial Cloth
Healthy volunteers will receive treatment to two body locations with the investigational product and placebo and the antimicrobial effectiveness of each treatment will be measured.
- Trial name
- NCT03229759
- Testing
- Octenidine Dihydrocloride in aqueous solution, Vehicle Control, Saline Control
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Labor Pain
Combined Spinal/Epidural (CSE) Saline Duration/Spread
An attempt is being made to see if by injecting a set volume of sterile saline into the epidural space during the treatment of labor pain with a combined spinal/epidural (CSE) increases the amount of pain relief obtained and…
- Trial name
- NCT01062893
- Testing
- Sterile normal saline 0 mls, 15 mls sterile normal saline
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
End-stage Renal Disease
Sodium Chloride and Protein-Bound Toxin Removal in Hemodiafiltration
An increase of the free fraction may allow a better removal of of protein-bound uremic toxins during dialysis. During predilution hemodiafiltration, the sodium chloride (NaCl) concentration will be increased in the infusion fluid…
- Trial name
- NCT01923961
- Testing
- HDF NaCl, Hemodialysis, Standard Predilution Hemodiafiltration
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- EXcorLab GmbH
Out-of-hospital Cardiac Arrest
Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
The overall goal of this study is to determine whether initiating hypothermia in cardiac arrest patients as soon as possible in the field results in a greater proportion of patients who survive to hospital discharge compared to…
- Trial name
- NCT00391469
- Testing
- Rapid infusion of 2 liters of 4oC normal saline, Rapid infusion of cold normal saline
- Where
- United States
- Volunteers
- 1,359 people
- Sponsor
- University of Washington
Coronary Artery Disease, Edema
The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
The organ dysfunction following cardiopulmonary bypass (CPB) occurs frequently in cardiac surgery patients. Systemic inflammatory response initiated by CPB through releasing of several mediators lead to altered endothelial…
- Trial name
- ESHHS (NCT01675453)
- Testing
- 7.2% NaCl plus 6% hydroxyethyl starch 200/0.5, 0.9% NaCl
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Obstruction; Catheter, Infusion Catheter (Vascular), Catheter; Complications (Indwelling Catheter)
Maintaining Patency in BioFlo Implanted Port Catheters With Saline Only Flushes
The purpose of this study is to determine the safest and most effective flushing solution for maintaining patency (unobstructed flow) in BioFlo implanted port catheters.
- Trial name
- NCT02923830
- Testing
- Heparinized saline catheter flush, Saline-only catheter flush
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- TriHealth Inc.
Pregnancy
Efficacy of Labor Epidurals for Postpartum Tubal Ligation
The goal of this study is to evaluate the effect of continuous postpartum epidural saline infusion on the reactivation of labor epidurals for postpartum tubal ligation surgery following vaginal delivery.
- Trial name
- NCT02564016
- Testing
- Normal Saline Infusion, Capped Epidural
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Postoperative Pain
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
This is a Phase 2b, randomized, double-blind, saline placebo- and active-controlled, multicenter study in subjects undergoing primary unilateral total knee arthroplasty (TKA) to evaluate the analgesic efficacy, safety, and…
- Trial name
- NCT03015532
- Testing
- HTX-011, Bupivicaine HCl, Ropivacaine
- Where
- 24 sites in United States
- Volunteers
- 285 people
- Sponsor
- Heron Therapeutics
Cystic Fibrosis
Hypertonic Saline and Mucociliary Clearance in Children
Previously, the investigators and others have shown that mucociliary clearance (MCC) is defective in patients with cystic fibrosis (CF) and it is now thought that alterations in airway mucus rheology figure prominently in the…
- Trial name
- NCT01293084
- Testing
- 0.12% saline, 7% saline
- Volunteers
- 17 people
- Sponsor
- Johns Hopkins University
Healthy
Study of Subcutaneous Hydration Enabled by Human Recombinant Hyaluronidase (Hylenex)
Randomized, double-blinded study that will evaluate the tolerability, safety, and flow rates of different solutions subcutaneously (SC) infused and preceded by human recombinant hyaluronidase (hylenex) 150 units.
- Trial name
- INFUSE-NSLR (NCT00656370)
- Testing
- recombinant human hyaluronidase
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Halozyme Therapeutics
Sinusitis
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Healthy children may develop symptoms of chronic sinusitis such as chronic cough, chronic runny nose, nasal congestion, even headaches.
- Trial name
- NCT00465530
- Testing
- Saline, Gentamycin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Julie Wei, MD
Postoperative Pain, Total Knee Arthroplasty
US Guided GNB vs Saline Injection for TKA
Do ultrasound-guided genicular nerve blocks with 0.5% bupivacaine provide improved knee analgesia for patients recovering from total knee replacement surgery compared to saline injection? Hypotheses: The investigators hypothesize…
- Conditions
- Postoperative Pain, Total Knee Arthroplasty, Nerve Block
- Trial name
- NCT03316118
- Testing
- bupivacaine, saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Northwestern University
Pancreatic Cancer
Placebo Controlled Trial of SOM230 for the Reduction of Post-Pancreatectomy Fistula, Leak, and Abscess
The purpose of this study is to help us learn more about how to lower the patient's risk of the most common complications after their pancreas operation.
- Trial name
- NCT00994110
- Testing
- Pasireotide (SOM230)
- Where
- United States
- Volunteers
- 439 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain
Bacteriostatic Normal Saline Versus Lidocaine for Intradermal Anesthesia
The purpose of this study is to determine if creation of a skin wheel with bacteriostatic normal saline, which includes 0.9% benzyl alcohol, is less painful and provides a similar level of anesthesia compared to 1% lidocaine.
- Trial name
- NCT04495868
- Testing
- Bacteriostatic Normal Saline, 1% Lidocaine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Bronchiolitis
Nebulized Hypertonic Saline for Bronchiolitis
This study aims to examine the effect of nebulized 3% hypertonic saline in the treatment of viral bronchiolitis. The investigators hypothesize that nebulized 3% saline will decrease rate of hospital admission, decrease clinical…
- Trial name
- NCT00619918
- Testing
- Nebulized 3% saline, Nebulized 0.9% saline
- Where
- 2 sites in United States
- Volunteers
- 447 people
- Sponsor
- Children's Hospital Los Angeles
Wounds and Injuries, Wound Healing
Negative Pressure Wound Therapy With Instillation of Saline Solution Versus Collagenase Ointment in Full-thickness Wounds
Evaluation of wound bed surface area containing clean, healthy viable tissue in full-thickness wounds.
- Conditions
- Wounds and Injuries, Wound Healing, Granulation Tissue
- Trial name
- ACCELERATE (NCT03722485)
- Testing
- Negative Pressure Therapy w/ instillation and dwell (NPWTi-d), Collagenase Ointment
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- KCI USA, Inc
Cystic Fibrosis
Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis
The objective of the study is to determine whether or not inhalation of hypertonic saline will be tolerated by infants with cystic fibrosis and the effect of inhalation on their lung function.
- Trial name
- NCT00753987
- Testing
- Hypertonic Saline
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Osteoarthritis
Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis
A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the efficacy of a single dose of Autologous Protein Solution (APS) in patients with Osteoarthritis (OA) of the knee.
- Trial name
- PROGRESS IV (NCT02905240)
- Testing
- nSTRIDE APS, Saline
- Where
- 27 sites in United States
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet