Clinical trials: Salivary Gland Cancer
Bladder Cancer, Breast Cancer
Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Conditions
- Bladder Cancer, Breast Cancer, Carcinoma of Unknown Primary, Esophageal Cancer
- Trial name
- NCT00014456
- Testing
- filgrastim, docetaxel, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parotid Tumor, Parotid Neoplasms
Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy
The parotid has a close relationship with the extra temporal course of the facial nerve. The study aimed to evaluate the accuracy and safety of trident landmark during superficial parotidectomy in the identification of the facial…
- Conditions
- Parotid Tumor, Parotid Neoplasms, Surgery, Head and Neck Disorder
- Trial name
- NCT04803032
- Testing
- Superficial parotidectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Salivary Gland Cancer, Salivary Gland Neoplasms
Survival With Patients Treated With Salivary Gland Cancer
Salivary gland malignancies is very heterogenous group of tumors regarding tumor histology and localization. The aim of this study is to assess main clinical and pathological parameters related to patients survival
- Trial name
- NCT05390294
- Testing
- Surgical intervention with or without postoperative adjuvant therapy
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Clinical Center of Vojvodina
Mucositis, Xerostomia
Effectiveness of Photobiomodulation Protocols in Radiation-induced Oral Side Effects in H&N Cancer Patients
Head and neck cancer (HNC) are among the most frequent malignancies in the world. The main treatment modalities for HNC are surgical excision, radiotherapy (RT), and chemotherapy (CT).
- Conditions
- Mucositis, Xerostomia, Hyposalivation
- Trial name
- NCT05242991
- Testing
- Photobiomodulation therapy
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- Federal University of Rio Grande do Sul
Carcinoma, Non-Small-Cell Lung
The Treatment of Advanced Lung Cancer With Dribbles Antigen by Targeting Activation of Tcells
Malignant tumor has become the leading cause of death in humans, and the number one killer in malignant tumor is the lung cancer.
- Trial name
- NCT03057340
- Testing
- Dribble vaccine
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer, Head and Neck Neoplasms
Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study
The Photobiomodulation therapy could have positive effects on quality of life and oral health in head and neck cancer survivors post-radiotherapy. The improvement in quality of life will be maintained after a follow-up period.
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Xerostomia
- Trial name
- LAXER (NCT05106608)
- Testing
- Energy density photobiomodulation (7.5), Energy density photobiomodulation (3)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer
Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial
Nasopharyngeal carcinoma (NPC) is the highest reported otorhinolaryngological malignancy reported in Malaysia affecting predominantly male adults between 40-60 years old [1, 2].
- Trial name
- NCT04491435
- Testing
- Summated Xerostomia Inventory, Sialometry
- Where
- Malaysia
- Volunteers
- 94 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Head and Neck Cancer, Non-melanomatous Skin Cancer
Radiation Therapy in Treating Patients With Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective for head and neck cancer.
- Trial name
- NCT00021125
- Testing
- adjuvant therapy, radiation therapy
- Where
- United Kingdom
- Volunteers
- 460 people
- Sponsor
- Medical Research Council
Thyroid Cancer
The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer
The purpose of this study is to determine whether the use of honey mouthwashes in the prevention of salivary side effects of 131I (radioiodine) therapy.
- Trial name
- NCT01833650
- Testing
- thymus honey mouthwash
- Where
- Cyprus
- Volunteers
- 120 people
- Sponsor
- Cyprus University of Technology
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
Sorafenib Tosylate, Cisplatin, and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
This phase I/II trial studies the side effects and the best dose of sorafenib tosylate and docetaxel when given together with cisplatin and to see how well they work in treating patients with recurrent or metastatic squamous cell…
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT02035527
- Testing
- sorafenib tosylate, cisplatin, docetaxel
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Salivary Gland Carcinoma
A Phase II Study of Advanced Salivary Gland Carcinoma Based on Molecular Typing
This is a single-center, open-label, phase 2 study to evaluate the efficacy and safety of target therapy for patients with relapsed/metastastic salivary gland carcinoma based on molecular typing.
- Trial name
- NCT05924256
- Testing
- SHR-A1811, SHR 3680 + leuprolide, SHR-A1921
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Fudan University
Malignant Neoplasm of Salivary Gland, Benign Neoplasm of Salivary Gland
Diagnostic Accuracy of Human Transcriptional Activator(MYB) Expression by ELISA Technique Versus Immmunohistochemistry in Detecting Salivary Gland Carcinomas
in this resarch we will use ELISA Technique to estimate Human Transcriptional Activator(MYB) Expression .compare it by Immmunohistochemistry analysis of MYB Expression in the malignant and benign salivary gland tumor
- Trial name
- NCT03687294
- Testing
- enzyme linked immunosorbent assay (ELISA)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Xerostomia
Comparing Over-the-counter Dry Mouth Remedies After Radiation
The purpose of this study is to compare the effectiveness of over-the-counter remedies for dry mouth.
- Trial name
- NCT00595933
- Testing
- sugar-free chewing gum, chewing gum, mouth rinse
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Head and Neck Cancer
Perifosine in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Phase II trial to study the effectiveness of perifosine in treating patients who have recurrent or metastatic head and neck cancer.
- Trial name
- NCT00062387
- Testing
- perifosine
- Where
- 12 sites in United States
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate or Salivary Gland Cancer
This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.
- Trial name
- NCT00588185
- Testing
- [18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Cancer, Head and Neck Neoplasms
Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy
Patients with head and neck cancer post-radiotherapy may improve their perceived and amount of saliva after a 3-month Photobiomodulation (PBM) therapy focuses on three main salivary glands (parotid, submandibular and sublingual…
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Xerostomia
- Trial name
- NCT05614843
- Testing
- Energy density photobiomodulation (7.5)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad de Granada
Head and Neck Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Side Effects of High-Dose Intensity-Modulated Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: Tests that measure how much saliva is made, hearing, swallowing, voice function, and quality of life may improve the ability to plan treatment for patients with advanced head and neck cancer and may help doctors find…
- Conditions
- Head and Neck Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Oral Complications of Radiation Therapy, Radiation Toxicity
- Trial name
- NCT00415025
- Testing
- adjuvant therapy, management of therapy complications, quality-of-life assessment
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Stomach Neoplasms
Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample
The goal of this study is to study NIS expression in benign and malignant breast and thyroid samples using archival formalin-fixed paraffin-embedded tissue sections.
- Conditions
- Breast Cancer, Stomach Neoplasms, Salivary Gland Neoplasms, Thyroid Cancer
- Trial name
- NCT00568438
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Stanford University
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Solid Tumors With PTCH1 Loss-of-function Mutations
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
This study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF)…
- Trial name
- NCT05199584
- Testing
- ENV-101 (taladegib)
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Biomedicines, Inc.