Clinical trials: Salt-sensitivity of Blood Pressure
Hypertension
Blood Pressure Response to Sodium in the Diet
Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) of the sodium-bicarbonate co-transporter gene (SLC4A5) are associated with hypertension.
- Trial name
- NCT01899495
- Testing
- High sodium diet and low sodium diet
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Salt-Sensitivity of Blood Pressure
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing.
- Trial name
- NCT06094816
- Testing
- Furosemide (Diuretic), Hypertonic Saline Infusion
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Hypertension,Essential
The Significance of Sodium Balance and the Value of Salt-blood Test in Identifying Salt Sensitive Patients
This is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis Salt-blood test is associated to a decrease in blood pressure.
- Trial name
- VASA (NCT05165823)
- Testing
- Sodium restriction
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Regional Hospital Holstebro
Salt-sensitivity of Blood Pressure
Gut Microbiome, Metabolome, and SSBP
The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pressure (SSBP).
- Trial name
- Gut-SSBP (NCT07790900)
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Genetics in Hypertension
Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health.
- Trial name
- Beta2AR (NCT07832942)
- Testing
- low sodium diet, high sodium diet, renal plasma flow
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Brigham and Women's Hospital
Hypertension
Skin Sodium and Salt Sensitivity of Blood Pressure
Eating too much salt raises blood pressure and the risk of having a heart attack or stroke. The investigators do not fully understand why salt raises blood pressure, but storage of sodium in the body, particularly in the skin…
- Trial name
- INTREPID (NCT05976438)
- Testing
- Amlodipine, Chlortalidone
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hypertension
Genetic Determinant of Blood Pressure Sensitivity to Salt Intake
Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of…
- Trial name
- JEU004 (NCT01706887)
- Testing
- Diet Amiloride
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Comparison on Blood Pressure Effect of an Equivalent Sodium Intake, With Different Nature, for Hypertensive Subjects
Numerous large-scale epidemiological studies have made it possible to establish a link between the average consumption of table salt (sodium chloride) and blood pressure figures.
- Trial name
- SODIVASC-II (NCT05108402)
- Testing
- Phenotyping, Drug intake
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sodium, Renal Function
The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects.
The study was a double-blinded, randomized, placebo-controlled cross-over study. 27 healthy subjects received a four days standardized, sodium reduced diet (100 mmol sodium) and treatment with sodium chloride (200 mmol sodium) or…
- Conditions
- Sodium, Renal Function, Blood Pressure
- Trial name
- EGNA (NCT06968182)
- Testing
- Sodium Chloride
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Frank Mose
Blood Pressure
Effects of Yoga on Sodium-induced Pressor Responses in African American Adults
This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.
- Trial name
- NCT05353270
- Testing
- Yoga, Waitlist control
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Texas State University