Clinical trials: Sarcopenia
Sepsis, Critical Illness
MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients
The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength.
- Conditions
- Sepsis, Critical Illness, ICU-acquired Muscle Weakness, ICU-acquired Weakness
- Trial name
- ICUAW (NCT07362862)
- Testing
- Electrical Muscle Stimulation System
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Health Discovery Labs
Osteoarthritis, Sarcopenia
The Efficacy of Nutrilite All-plant Protein Booster to Improve Sarcopenia and Osteoarthritis in Middle-aged and Elderly People
The goal of this clinical trial is to learn whether Amway Nutrilite All-plant protein booster prototype product (test product) will improve sarcopenia (SA) and osteoarthritis (OA) in middle-aged and elderly people.
- Trial name
- NCT06499012
- Testing
- All-plant Protein Booster Product Group
- Where
- China
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Amway (China) R&D Center
Sarcopenia, Body Composition
Validation of a Body-Composition Segmentation Software on a Diverse Public CT Scan Cohort
This study evaluates the standalone performance of Soma, a deep-learning software developed by Nucleo Research, Inc. for the automated segmentation of body-composition tissues (skeletal muscle, subcutaneous adipose tissue…
- Conditions
- Sarcopenia, Body Composition, Obesity
- Trial name
- SOMA (NCT07600866)
- Testing
- Soma Body-Composition Segmentation Software
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nucleo Research, Inc.
Sarcopenia, Frailty
Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty
The study will be conducted to investigate the efficacy, tolerability and pharmacokinetics of MYMD1 in participants with chronic inflammation associated with sarcopenia/frailty, a condition linked to elevated levels of…
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT05283486
- Testing
- MYMD-1 600MG, MYMD-1 750mg, MYMD-1 900mg
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- TNF Pharmaceuticals, Inc.
Sarcopenia in Elderly
A Study of PLH-2301 in Subjects With Sarcopenia
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of PLH-2301 in subjects with sarcopenia.
- Trial name
- PLH-2301_P2 (NCT07390552)
- Testing
- PLH-2301
- Where
- 5 sites in South Korea
- Volunteers
- 168 people
- Sponsor
- Pluto Inc.
Frailty, Muscle Loss
A Randomized-Control Study of Gym Tonic's Community Based Strength Training Intervention.
Launched in April 2015 , Gym Tonic is the first of its kind cross-border exercise-as-medicine partnership between research institutions, business enterprises and service providers from Singapore and Finland.
- Conditions
- Frailty, Muscle Loss, Sarcopenia
- Trial name
- NCT04661618
- Testing
- Gym Tonic programme and Gym equipment
- Where
- Singapore
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- PulseSync Pte Ltd
Sarcopenia, COPD
Evaluate the Effect of Dietary Supplement Combined Exercise Among Patients With Sarcopenia Comorbid With Lung Disease
This trial is a prospective multi-center study. The purpose of this study is to evaluate the effect of dietary supplement combined with supervised exercised on the physical performance, body composition and lung function among…
- Conditions
- Sarcopenia, COPD, ILD
- Trial name
- NCT05926713
- Testing
- Sarcojoint®, supervised exercise
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Orient Europharma Co., Ltd.
Sarcopenia
Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2
Men and women lose muscle mass and strength with age. Loss of muscle mass and strength is accompanied by a loss of muscle function which can lead to diminished quality of life and more importantly can lead to serious fall…
- Trial name
- NCT02043171
- Testing
- HMB plus Vitamin D, Non-Exercise, Exercise
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.
Sarcopenia
Evaluation of Safety and Efficacy of a Digital Therapeutic Device to Improve Strength in Sarcopenia (Sarc-DTx)
This clinical trial aims to demonstrate that the use of a digital therapeutic device (exoDTx) in patients with sarcopenia is superior to self-exercise in terms of muscle strength improvement and safety.
- Trial name
- NCT07319377
- Testing
- exoDTx, Self-exercise (Educational Material)
- Where
- 2 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Exosystems
Hip Fracture
Treatment of Sarcopenia in Post-Hip Fracture Patients (0677-032)
The purpose of this study is to demonstrate an improvement in physical functional recovery, following administration of Drug for 24 weeks, in patients who have recently experienced a hip fracture.
- Trial name
- NCT00128115
- Testing
- MK0677
- Where
- 5 sites in Germany, Norway and 3 more
- Volunteers
- 83 people
- Sponsor
- Merck Sharp & Dohme LLC
Ulcerative Colitis (Disorder), Crohn Disease
Partial Enteral Nutrition to Prevent Weight Loss and Sarcopenia in IBD Patients at Nutritional Risk - SIMBA
This is a multicenter, open-label, randomized two-arm interventional nutritional study evaluating the effects of partial enteral nutrition (LH VIOLA) in patients with Inflammatory Bowel Disease (IBD) at risk of malnutrition.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease, Malnutrition or Risk of Malnutrition, IBD
- Trial name
- SIMBA (NCT07433946)
- Testing
- LH VIOLA Supplementation
- Where
- 4 sites in Italy
- Volunteers
- 146 people
- Sponsor
- Lionhealth Srl Società Benefit
Sarcopenia, Back Pain
The "Free From Pain Exercise Book" Versus "The Back Book".
This pragmatic randomised control feasibility trial aims to investigate the effectiveness of the "Free From Pain Exercise Book" in comparison to "The Back Book" for reducing back pain in adults aged 60 and over.
- Conditions
- Sarcopenia, Back Pain, Arthritis
- Trial name
- NCT05359107
- Testing
- "The Free From Pain Exercise Book", "The Back Book"
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Talita Cumi Ltd.
Sarcopenia, Obesity and Obesity-related Medical Conditions
INTERMEDIATE-SIZE PATIENT POPULATIONS EXPANDED ACCESS TO TREATMENT FOR SARCOPENIC OBESITY
The expanded access is designed for patients requesting the treatment, and whose medical condition may benefit from treatment, but are unable to participate in any other IMM01-STEM clinical trial in their physician's opinion for…
- Trial name
- STEM-META-EAP (NCT06784297)
- Testing
- IMM01-STEM
- Sponsor
- Immunis, Inc.
Sarcopenia
Investigating Loss of Neuromuscular Junction Transmission Fidelity in Older Adults
Sarcopenia is a condition characterised by age-related loss of muscle mass and function. Factors affecting the strength of muscle contraction independent of mass, such as neuromuscular junction (NMJ) transmission, are…
- Trial name
- STAMINA (NCT04904926)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NMD Pharma A/S
Sarcopenia in Elderly
A Study to Evaluate the Efficacy and Safety of IN-207907 Injection in Elderly Patients With Sarcopenia
The goal of this clinical trial is to learn if intervention can treat sarcopenia in the elderly. Researchers will compare IN-207907 120 mg, 240 mg, 360 mg and placebo to see if SPPB score improves.
- Trial name
- NCT07668180
- Testing
- IN-207907 120 mg, IN-207907 240 mg, IN-207907 360 mg
- Volunteers
- 100 people
- Sponsor
- HK inno.N Corporation
Sarcopenia
Clinical Trial of CG-BM1 Allogeneic Human Bone Marrow Mesenchymal Stem Cell Injection in the Treatment of Sarcopenia
1. To evaluate the safety and tolerability of CG-BM1 for the treatment of patients with Sarcopenia. 2. To observe the preliminary effectiveness of CG-BM1 in treating Sarcopenia patients.
- Trial name
- CGBM1-SAR-01 (NCT07865676)
- Testing
- CG-BM1- 5.0 × 10^7 cells, CG-BM1-1.0 × 10^8 cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- GuangZhou Cellgenes Biotechnology Co., Ltd.
Sarcopenia
Study of Efficacy and Safety of AVTR101 in Sarcopenic Elderly
The goal of this clinical trial is to primarily evaluate the efficacy of AVTR101 to placebo on physical performance in sarcopenia patients.
- Trial name
- NCT06788236
- Testing
- AVTR101
- Where
- 4 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Aventi Biotechnology Inc.
Sarcopenia
Clinical Study of TJ0113 Capsule in the Treatment of Patients With Sarcopenia
This study is a randomized, double-blind, multicenter, placebo parallel-controlled Phase II clinical study designed to evaluate the clinical efficacy and safety of TJ0113 Capsule in patients with sarcopenia.
- Trial name
- NCT07620938
- Testing
- TJ0113
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Hangzhou PhecdaMed Co., Ltd.
Metastatic Colorectal Cancer
A Study to Assess the Impact of Sarcopenia on the Outcomes of Colorectal Cancer Patients Treated With Chemotherapy Combined With Bevacizumab
The purpose of this study is to explore the relationship between sarcopenia, as defined by computed tomography, treatment related outcomes and other body composition related parameters in a patient population receiving…
- Trial name
- NCT02673710
- Testing
- No intervention
- Where
- 23 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Hoffmann-La Roche
Muscle Strength, Sarcopenia
Nutritional Intervention for Age-related Muscular Function and Strength Losses
The purpose of the study is to Test the effect of a dietary supplement beta-hydroxy-beta-methylbutyrate (HMB) with and without Vitamin D to prevent and reverse the losses of muscular strength and functionality in older adults.
- Trial name
- NCT00874575
- Testing
- Vitamin D, Beta-hydroxy-Beta-methylbutyrate, Beta-hydroxy-Beta-methylbutyrate and Vitamin D
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.