Clinical trials: Sarcopenia
Sarcopenia
Muscle Capillarization and Sarcopenia
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders.
- Trial name
- NCT03984994
- Testing
- Aerobic exercise training, Strength training
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cirrhosis, Aerobic Exercises
The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis
The goal of this randomized controlled trial is to investigate whether a 16-week structured aerobic exercise program combined with nutritional consultation can improve autonomic and endothelial function in patients with…
- Conditions
- Cirrhosis, Aerobic Exercises, Lifestyle Modification, Endothelial Function
- Trial name
- NCT06288828
- Testing
- Aerobic exercise + Nutrition consultant, Nutrition consultant
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Bone Loss, Hypotensive
Blood Flow and Bone Density in Healthy Adult Women
This project will test the efficacy of using a non-invasive neuromuscular stimulation on the plantar surface of the feet to prevent and/ or reverse bone loss in a sample of healthy adult women.
- Conditions
- Bone Loss, Hypotensive, Lower Limb Fluid Pooling
- Trial name
- NCT00397462
- Testing
- calf muscle pump stimulation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Sarcopenia, Osteopenia
Effect of a Ghrelin Receptor Agonist on Muscle and Bone
Adults with low muscle mass also usually have low bone mass, making them vulnerable to falls, fractures and other injuries. This project will determine the effectiveness of treatment with a ghrelin receptor agonist in improving…
- Trial name
- NCT04021706
- Testing
- Anamorelin Hydrochloride
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tufts University
Aging, Sarcopenia
Dietary Nitrate and Muscle Power With Aging
The purpose of this study is to see if drinking beetroot juice (BRJ) is beneficial for aging patients. We hope to determine the effect of BRJ on exercise performance.
- Trial name
- NCT03513302
- Testing
- nitrate
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sarcopenia, Gait Disorders in Old Age
A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT)
The main objective of the study is to evaluate the effect of two daily doses of BIO101 versus placebo on mobility function as measured by gait speed using the 400MW test.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-INT (NCT03452488)
- Testing
- BIO101
- Where
- 22 sites in United States, Belgium
- Volunteers
- 233 people
- Sponsor
- Biophytis
Sarcopenia
Effects of a Resistance Training Program in Older Women With Sarcopenia
This is a randomized clinical trial with a control group that will test how periodized resistance training will impact measures of sarcopenia in older women who have been identified as presarcopenic or sarcopenic.
- Trial name
- RESTORE-ME (NCT02628145)
- Testing
- Resistance Training Intervention, Active Control Group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rhode Island
Sarcopenia
Carnitine Supplementation and Skeletal Muscle Function
Research project objectives The primary aim of the current research project is to use carnitine supplementation as the anti-inflammatory intervention for exploring the relationship between inflammation and associated with aging…
- Trial name
- NCT02692235
- Testing
- carnitine
- Where
- Poland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Sarcopenia
A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study
This extension study was a 24-week off-drug follow-up of the core CBYM338E2202 (NCT ) study and the main objective was to determine the long-term durability of bimagrumab (BYM338) effect after a 6-month treatment period.
- Trial name
- NCT02468674
- Testing
- bimagrumab
- Where
- 30 sites in United States, Australia and 10 more
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Sarcopenia
Dose Range Finding Study of Bimagrumab in Sarcopenia
The purpose of this study was to determine the efficacy of repeat dosing with multiple dose levels of bimagrumab on patient physical function, skeletal muscle mass and strength in older adults with sarcopenia.
- Trial name
- NCT02333331
- Testing
- bimagrumab
- Where
- 58 sites in United States, Australia and 11 more
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Sarcopenia
Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.
- Trial name
- NCT04830514
- Testing
- Recommended Dietary Allowance of Protein, Habitual protein intake, Optimal Protein Intake
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hypogonadism, Diabetes
Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.
Background: Men≥65 years often produce lower levels of testosterone, meaning there is less testosterone circulating to the tissues of the body.
- Conditions
- Hypogonadism, Diabetes, Sarcopenia, Osteoporosis
- Trial name
- NCT00104572
- Testing
- Androgel (Testosterone Gel), Anastrozole (Aromatase Inhibitor), Calcium Cardone 500mg with vitamin D 400 IU
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Chronic Kidney Disease, Sarcopenia
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease
Chronic kidney disease is associated with the loss of skeletal muscle mass and function. This process detrimentally impacts mobility, functional independence, and quality of life.
- Conditions
- Chronic Kidney Disease, Sarcopenia, Frailty
- Trial name
- CoNR (NCT03579693)
- Testing
- CoQ10, Nicotinamide riboside
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Sarcopenia
Ankle Assistance and Resistance in Older Adults
The goal of this research protocol is to improve mobility in older individuals through advances in wearable assistive devices by focusing on two specific aims.
- Trial name
- NCT06284525
- Testing
- Ankle resistance and biofeedback
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University