Clinical trials: Sarcopenic Obesity
Heart Failure with Preserved Ejection Fraction (HFPEF), Heart Failure with Reduced Ejection Fraction
Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Study
This study is designed to evaluate the safety, feasibility, and effectiveness of a 12-week eccentric exercise program for older adults with sarcopenia (muscle loss) or sarcopenic obesity and chronic heart failure (HF).
- Conditions
- Heart Failure with Preserved Ejection Fraction (HFPEF), Heart Failure with Reduced Ejection Fraction, Sarcopenia in Elderly, Sarcopenic Obesity
- Trial name
- ECLYPSE-HF (NCT06826963)
- Testing
- Aerobic eccentric intervention
- Where
- 2 sites in Italy
- Volunteers
- 15 people
- Sponsor
- Universita di Verona
Sarcopenic Obesity, Obesity
Molecular Mechanisms Underpinning Sarcopenic Obesity
The coexistence of obesity and sarcopenia results in sarcopenic obesity, a high-risk geriatric condition associated with metabolic perturbations and several co-morbidities.
- Conditions
- Sarcopenic Obesity, Obesity, Sarcopenia, Aging
- Trial name
- NCT06120647
- Testing
- Essential amino acids (EAA)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- The Swedish School of Sport and Health Sciences
Obesity, Sarcopenia
GLP-1 Receptor Agonist Use and Sarcopenia in Obese Individuals Without Diabetes
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/GIP agonists such as semaglutide and tirzepatide produce marked weight loss in people with obesity, with reported reductions of about 15-20%.
- Trial name
- GLP1-SARCO (NCT07858864)
- Testing
- GLP-1 receptor agonist (e.g., semaglutide, tirzepatide) - prescribed by the treating physician as standard care; the study does not assign or alter treatment.
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul Saglik Bilimleri University
Sarcopenic Obesity
Sarcopenic Obesity in Liver Transplanted Patients
The prevalence of obesity in cirrhotic patients who are candidates for liver transplantation (LT) is increasing, a phenomenon consistent with the increased prevalence of obesity in the general population.
- Trial name
- OSaLT (NCT05029713)
- Testing
- Evaluation of appendicular skeletal muscle mass (ASMM) by bioelectrical impedance analysis (BIA)
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- University of Bari
Obese, Sarcopenic Obesity
Effect of Combined Resisted Training and Protein-based Diet on Frailty in Sarcopenic Elderly Women
Sixty obese elderly women will be recruited from Fawkia hospital outpatient clinic diagnosed by sarcopenia and randomly allocated into two groups for a 12-week intervention.
- Trial name
- NCT07627919
- Testing
- supervised resistance exercise training and a, high -protein diet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Sarcopenic Obesity, Sarcopenia
Lifestyle Modifications for the Treatment of Sarcopenic Obesity
This study evaluates the addition of a high-protein energy-restricted diet to exercise in the treatment of sarcopenic obesity in people aged 65 and over.
- Conditions
- Sarcopenic Obesity, Sarcopenia, Obesity
- Trial name
- NCT02379026
- Testing
- Protein Drink/Diet, Exercise, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Exercise Adherence
Effectiveness of a Peer Support Media Model on Obesity and Sarcopenia Awareness in At-Risk College Students
Sarcopenic obesity refers to a condition characterized by high body fat percentage and insufficient muscle mass, posing significant risks to physical and mental health.
- Trial name
- NCT06964880
- Testing
- Exercise with video on media platform, Printed Educational Handout
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Frailty, Sarcopenic Obesity
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
The continuing increase in prevalence of obesity in older adults including many older Veterans has become a major health concern.
- Conditions
- Frailty, Sarcopenic Obesity, Aging
- Trial name
- DEMFOS (NCT04221750)
- Testing
- Lifestyle therapy, Metformin Hydrochloride, Healthy Lifestyle
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sacropenic Obesity
Effects of the EatWelLog App on Enhancing Diet Management for Older Adults With Sarcopenic Obesity
Background: Sarcopenic obesity (SO) affects 10% of older adults increased to 23% of those 75+, raising health risks and health cost.
- Trial name
- NCT07867795
- Testing
- Dietary Modification programme, Exercise Training, The EatWelLog App
- Where
- Hong Kong
- Volunteers
- 212 people
- Sponsor
- The Hong Kong Polytechnic University
Muscle Performance, Sarcopenic Obesity
Safety and Efficacy of IMM01-STEM Against Placebo on Muscle Performance in Seniors With Obesity and Muscle Weakness
Placebo controlled study for safety and efficacy of IMM01-STEM on muscle performance in seniors with obesity and muscle weakness
- Trial name
- NCT06600581
- Testing
- IMM01-STEM
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- Immunis, Inc.
Sarcopenic Obesity, Chronic Obstructive Pulmonary Diseases
Protein, Sarcopenic Obesity, and COPD
Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults.
- Trial name
- PROSO-COPD (NCT06735573)
- Testing
- the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Aberdeen
Sarcopenic Obesity
Nutritional Supplementation in Sarcopenic Obesity
The obese patient presents a quantitative and qualitative deficit of muscle mass as occurs in the elderly subject that was named Sarcopenic Obesity (SO).
- Trial name
- SARCO (NCT05143398)
- Testing
- Diet + protein, Diet + EAA, Diet + EAA and TCA
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Sarcopenia
Pilot Study of the Human Metagenome in Metabolic Diseases
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
- Conditions
- Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation
- Trial name
- NCT06363253
- Testing
- No specific intervention
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Sarcopenia, Sarcopenic Obesity
Diet in Elderly With Type 2 Diabetes
Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass which may affect performance. Diabetes can affect muscle cell function, making sarcopenia worse.
- Conditions
- Sarcopenia, Sarcopenic Obesity, Diabetes Mellitus, Diabetes Mellitus, Type 2
- Trial name
- SARC-OLD (NCT05961878)
- Testing
- mediterranean diet with adequate protein intake
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sarcopenic Obesity, Obesity and Overweight
Effectiveness of Different Types of Training in Older Adults With Sarcopenic Obesity
This study is a randomized, parallel-group, double-blind clinical trial. The primary aim is to assess the effectiveness of power-based resistance training, multimodal exercise incorporating non-specific movements, and a control…
- Conditions
- Sarcopenic Obesity, Obesity and Overweight, Sarcopenia
- Trial name
- NCT06895122
- Testing
- High resistance training, Multicomponent Training
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- University of Salamanca
Esophageal Cancer, Gastric Cancer
Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer
In line with improvements in oncologic outcome for patients with esophageal cancer, the attritional impact of curative treatment with respect to functional status and health-related quality of life (HR-QL) in survivorship is…
- Conditions
- Esophageal Cancer, Gastric Cancer, Sarcopenia, Sarcopenic Obesity
- Trial name
- NCT03061370
- Testing
- Esophagectomy or Gastrectomy
- Where
- 2 sites in Ireland
- Volunteers
- 317 people
- Sponsor
- St. James's Hospital, Ireland
Sarcopenic Obesity
Dietary Modification Intervention Involving Family Support (FamNUTRI) for Managing Sarcopenic Obesity Among Community-dwelling Older Adults
The goal of this pilot RCT is to examine the feasibility and preliminary effects of a dietary modification intervention involving family support (FamNUTRI) on the management of sarcopenic obesity among older people living in the…
- Trial name
- NCT06933823
- Testing
- Dietary modification intervention involving family support, Dietary modification intervention
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- The Hong Kong Polytechnic University
Sarcopenia, Gait Disorders in Old Age
An OBServational Clinical Trial (SARA-OBS) in Sarcopenia and Sarcopenic Obesity in Patients Aged 65 Years and Over
The SARA-OBS is a single arm phase 2 clinical trial, with no investigational product and no therapeutic intervention that will be conducted in three European countries, (Belgium, France and Italy), and in the US.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-OBS (NCT03021798)
- Testing
- No Drug and no aspecific intervention
- Where
- 7 sites in United States, Belgium and 2 more
- Volunteers
- 218 people
- Sponsor
- Biophytis
Obesity
Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Population of Adult Obese Patients
This project aims first to determine the prevalence of sarcopenia in a population of obese people of extended age group (18-70 years).
- Trial name
- OBESAR (NCT03394469)
- Testing
- collection
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sarcopenia, Sarcopenic Obesity
The Relationship Betweensarcopenia And Myosteatosis With The Natural History Of Liver Cirrhosis
Malnutrition is a common figure associated with liver cirrhosis. The main component of malnutrition in liver cirrhosis is represented by sarcopenia, a condition of a progressive and generalized loss of muscle mass and strength.
- Conditions
- Sarcopenia, Sarcopenic Obesity, Cirrhosis, Liver
- Trial name
- NCT04466709
- Testing
- none intervention type
- Where
- Italy
- Volunteers
- 374 people
- Sponsor
- University of Roma La Sapienza