Clinical trials: Sars-CoV-2 Infection
COVID-19
Treating COVID-19 With Hydroxychloroquine (TEACH)
Treatments for COVID-19 are urgently needed. Hydroxychloroquine (HCQ) is an antimalarial and immunomodulatory agent being repurposed for COVID-19 therapy based off in vitro data suggesting a possible antiviral effect.
- Trial name
- NCT04369742
- Testing
- Hydroxychloroquine (HCQ)
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- NYU Langone Health
SARS-CoV Infection, COVID-19
COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations
Background: Allergic reactions have been reported to occur after vaccination with both the Pfizer-BioNTech COVID-19 Vaccine and Moderna COVID-19 Vaccine.
- Conditions
- SARS-CoV Infection, COVID-19, Allergic Reaction, Mast Cell Disorder
- Trial name
- SARS (NCT04761822)
- Testing
- Moderna COVID-19 Vaccine, Pfizer-BioNTech COVID-19 Vaccine
- Where
- 29 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients
The efficacy of natural foods such as freeze-dried mare's milk (Saumal) in post-COVID syndrome therapy has not been studied. The literature review has shown that researchers have focused more on evidence-based medications and…
- Trial name
- NCT05970861
- Testing
- Freeze-dried Mare Milk (Saumal)
- Where
- Kazakhstan
- Volunteers
- 75 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Long COVID, Long Covid19
RECOVER-AUTONOMIC Platform Protocol
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06305780
- Testing
- IVIG + Coordinated Care, Ivabradine + Coordinated Care, IVIG + Usual Care
- Where
- 50 sites in United States
- Volunteers
- 381 people
- Sponsor
- Kanecia Obie Zimmerman
COVID-19 Pneumonia
The Development of a COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores
This is a study trial to assess the effectiveness of the immune response stimulated by the genetically engineered Bacillus subtilis which express and display Spike protein of the SARS-COV2 on the spore coat.
- Trial name
- NCT05057923
- Testing
- Bacillus subtilis
- Where
- Hong Kong
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- DreamTec Research Limited
COVID-19, Muscle Atrophy
Electrical Stimulation for Critically Ill Post-Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- COVID-19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase II (NCT05198466)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Melanoma
Targeted Melanoma Detection With Skin Self-Examination During COVID-19 Restricted Physician Access
The purpose of this study is to reduce melanoma mortality by improving early detection of melanoma with skin self-examination (SSE) among people who self-identify as being at risk and seek care for a concerning mole.
- Trial name
- TMD (NCT04420273)
- Testing
- SSE educational intervention, Active control:Healthy Living
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University
COVID
Prophylactic Ivermectin in COVID-19 Contacts
asymptomatic family close contact of confirmed COVID -19 patient will receive prophylactic ivermectin and will be followed up for 14 days for any symptoms \& diagnosis of COVID -19
- Trial name
- NCT04422561
- Testing
- Ivermectin Tablets
- Where
- Egypt
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Zagazig University
COVID-19
Communities Fighting COVID Return to School
San Diego State University (SDSU), a designated Hispanic-serving institution, is partnering with Sweetwater Union High School District, an independent public school district serving 90% ethnic minority and a high proportion of…
- Trial name
- NCT05150860
- Testing
- At-home COVID-19 testing, Onsite COVID-19 testing
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Asthma, Environmental Exposure
Home Air Quality Impact for Adults With Asthma
The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.
- Conditions
- Asthma, Environmental Exposure, Home Environment Related Disease
- Trial name
- NCT05224076
- Testing
- Home Air Quality
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Kansas Medical Center
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the…
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04973488
- Testing
- Therapeutic plasma exchange
- Where
- Romania
- Volunteers
- 38 people
- Sponsor
- Novacescu Alexandru
Covid-19, Deconditioning
Predictors of Recovery and the App-Facilitated Tele-Rehabilitation (AFTER) Program for COVID-19 Survivors
The aim of this study is to investigate the feasibility (safety, adherence) and initial efficacy (physical function and patient reported outcomes) of a multicomponent tele-rehabilitation program during COVID-19 recovery of…
- Trial name
- AFTER (NCT04663945)
- Testing
- Biobehavioral Tele-rehabilitation Sessions
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Colorado, Denver
Social Emotional Wellness
Implementing and Evaluating a Social-Emotional Learning Program for Refugee Children During the COVID-19 Pandemic
The overall goal of this overall goal is to pilot an adaptation of an established Social-Emotional Learning Program with novel wellness and COVID-19 safety components that are trauma-informed and culturally-specific in a…
- Trial name
- NCT04931888
- Testing
- EMPOWER
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
COVID
RAS and Coagulopathy in COVID19
To determine whether the coagulopathy associated with COVID-19 infection is driven by overactivation of the renin angiotensin system (RAS)
- Trial name
- NCT04419610
- Testing
- TRV027, sodium chloride 0.9%
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Advance Care Planning, Palliative Care
Palliative Care Educator
The investigators propose to conduct a stepped wedge cluster randomized trial of an advance care planning (ACP) educator-led intervention among hospitalized patients aged 65 and over, or any patient with Alzheimer's Disease and…
- Conditions
- Advance Care Planning, Palliative Care, Alzheimer's Disease and Related Dementias, Doctor-patient Communication
- Trial name
- VIDEO-PCE (NCT04857060)
- Testing
- ACP Educator led, video assisted discussion
- Where
- 2 sites in United States
- Volunteers
- 11,174 people
- Sponsor
- Tufts Medical Center
Bioequivalence
Bioequivalence Study of Favipiravir 200 mg Film Tablet (ATABAY, Turkey) Under Fasting Conditions
A single dose of Reference product containing 200 mg favipiravir and a single dose of Test product containing 200 mg favipiravir or vice versa; administered with 240 mL of water at room temperature, in each period under fasting…
- Trial name
- Favipiravir (NCT04406194)
- Testing
- FAVICOVIR 200 mg Film Tablet, AVIGAN 200 mg Film Tablets
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atabay Kimya Sanayi Ticaret A.S.
COVID
Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation
Interventional, randomized, double-blind, placebo-controlled study encompassing 2 development phases (Phase 2 and Phase 3).
- Trial name
- NCT04447469
- Testing
- mavrilimumab
- Where
- 32 sites in United States, Brazil and 3 more
- Volunteers
- 814 people
- Sponsor
- Kiniksa Pharmaceuticals International, plc
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy
This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Symptomatic COVID-19 Infection Laboratory-Confirmed
- Trial name
- NCT04532372
- Testing
- Best Practice, Leflunomide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- City of Hope Medical Center
COVID-19
Bidirectional Oxygenation Valve in the Management of Pulmonary Complications of COVID-19
The objective of this study is to determine the safety, feasibility and efficacy of a bidirectional oxygenation Positive End Expiratory Pressure (PEEP) mouthpiece in coronavirus disease 2019 (COVID-19) patients requiring…
- Trial name
- GO2 PEEP (NCT04331366)
- Testing
- GO2 PEEP MOUTHPIECE
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Emory University
Respiratory Viral Infection, Antiviral Treatment
An Open Label Study in Adults to Test the Efficacy of Mitoquinone/Mitoquinol Mesylate to Prevent Severe Viral Illness
Open label clinical trial of persons (adults) that will determine the safety and efficacy of the diet supplement oral mitoquinone/mitoquinol mesylate (Mito-MES) to prevent the development and progression of severe viral…
- Conditions
- Respiratory Viral Infection, Antiviral Treatment, COVID-19
- Trial name
- NCT05381454
- Testing
- Mitoquinone/mitoquinol mesylate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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