Clinical trials: Scheduled Cesarean Sections
Cesarean, Spinal Anesthesia
Prediction of Maternal Arterial Hypotension After Spinal Anesthesia by Passive Leg Raise Test.
Spinal anesthesia for cesarean section is associated with a high incidence of low blood pressure. However, the pathophysiology of this arterial hypotension is not unequivocal and could involve, in addition to drug vasoplegia, a…
- Trial name
- EDLIDL (NCT05133271)
- Testing
- Clinical hemodynamic and echocardiographic evaluation
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transient Tachypnea of the Newborn
Physiologically Based Cord Clamping To Improve Neonatal Outcomes After Elective Cesarean Delivery
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid.
- Trial name
- PhyCord1 (NCT06278415)
- Testing
- Physiological based cord clamping, Differed cord clamping
- Where
- 2 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Queen Fabiola Children's University Hospital
Pregnancy, Cesarean Delivery
Manual and Expressed Placental Removal at Cesarean Delivery and Its Effects on Various Cardiac Indices
The purpose of this study is to evaluate whether manual removal of the placenta during a cesarean delivery results in higher changes in the resistance of blood flow throughout the body, also called systemic vascular resistance…
- Trial name
- NCT00711451
- Testing
- Manual removal, Expressed removal
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Women's Health, Perinatal Care
Contribution of Virtual Reality in the Management of Patients Undergoing Scheduled Cesarean Section - VR-SCS
Cesarean deliveries account for 20.7% of all deliveries in France, according to the latest perinatal survey. At Nice University Hospital, the C-section rate over the last 5 years is around 19%.
- Conditions
- Women's Health, Perinatal Care, Cesarean, Analgesia
- Trial name
- VR-SCS (NCT06622408)
- Testing
- HypnoVR© virtual reality headset
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Postoperative Hypothermia
Prevention of Maternal Hypothermia After Scheduled Caesarean Section Using Active Intravenous Warming
Maternal hypothermia is very frequent after caesarean delivery under spinal anaesthesia and should be prevented, as it induces discomfort and increases the risk of postoperative complications.
- Trial name
- CESAR-RESOL2 (NCT03581721)
- Testing
- enFlow® IV fluid warmer and from July 2019 Fluido®Compact IV fluid warmer
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Shivering, Dose Finding Study
Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery
The purpose of this study is to determine the optimum dose of Dexmedetomidine to stop shivering in 90% of patients who experience shivering during scheduled elective cesarean deliveries.
- Trial name
- NCT04730609
- Testing
- Dexmedetomidine
- Where
- United States
- Sponsor
- Mayo Clinic
Pregnant Women
Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Hyperbaric bupivacaine 0.5% associated with opioids is the local anesthetic the most commonly used for spinal injection in cesarean section.
- Trial name
- NCT03036384
- Testing
- HB Prilocaine 2% (varying dose), HB Prilocaine 2%, Sufentanil
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Stillborn Caesarean Section
Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections
Intrathecal (i.t.) administration of isobaric bupivacaine, ropivacaine and levobupivacaine with addition of fentanyl for c-section either combined or not with administration of 10 ml of N/S 0,9% epidurally, in order to extent…
- Trial name
- NCT01558713
- Testing
- Bupivacaine- Fentanyl - Normal Saline, Ropivacaine-Fentanyl-Normal Saline, Levobupivacaine- Fentanyl- Normal Saline
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Patras
Preoperative Anxiety, Cesarean Delivery
Video Versus Verbal Preoperative Education in Elective Cesarean Delivery
This prospective randomized controlled trial aims to evaluate the effects of verbal and video-based preoperative education on anxiety levels and serum cortisol response in women scheduled for elective cesarean delivery under…
- Conditions
- Preoperative Anxiety, Cesarean Delivery, Stress Response
- Trial name
- VIDEO-CS (NCT07647601)
- Testing
- Video-Based Preoperative Education, Verbal Preoperative Education
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Scheduled Cesarean Sections, Postoperative Pain Management
Low Pain Prediction in Cesarean Section Patients
The investigators are attempting to see if eliminating the amount of long acting spinal narcotic during cesarean section delivery will demonstrate pain scores with movement when evaluated 24 hours postoperatively as those that…
- Conditions
- Scheduled Cesarean Sections, Postoperative Pain Management, Side Effects
- Trial name
- NCT02143141
- Testing
- duramorph
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Pregnant People, Anxiety
Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial
Patients presenting for a scheduled cesarean delivery who require a neuraxial anesthetic will be randomized to receive intravenous remimazolam or dexmedetomidine for procedural sedation during the placement of their spinal or…
- Trial name
- NCT07651956
- Testing
- Remimazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pregnant Women
Estimation of the Effective Dose (ED) 95 of Intrathecal Hyperbaric Prilocaine 2% for Scheduled Cesarean Delivery.
Prilocaine is a local anesthetic drug which as an intermediate duration of action shorter than bupivacaine 0,5% that is usually used for spinal anesthesia in scheduled cesarean section.
- Trial name
- NCT03607916
- Testing
- Hyperbaric prilocaine 2%, Morphine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Cesarean Section Complications
Towards Enhanced Recovery After Cesarean
One in 300 women will become persistent opioid users after cesarean delivery (1). Cesarean delivery is the most common surgical procedure in the United States, representing 31.9% of the 3,788,235 deliveries in 2018 (2).
- Trial name
- ERAS (NCT04612920)
- Testing
- Ibuprofen, acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Oklahoma
High-risk Nulliparous Pregnancy, Patients Scheduled for Cesarean Section, Surgical Fear, Preoperative Anxiety, and Cortisol Level
The Effect of Mandala Art Therapy on Surgical Fear and the Stress Hormone (Cortisol) in High-risk Pregnant Women Before Cesarean Section.
This randomized controlled study aims to evaluate the effect of mandala art therapy applied before cesarean section on surgical fear and cortisol levels in high-risk pregnant women.
- Trial name
- NCT07691320
- Testing
- Mandala Art Therapy
- Volunteers
- 142 people
- Sponsor
- Inonu University
Postpartum Hemorrhage
Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section
Postpartum hemorrhage (PPH) ranks among the leading causes of maternal morbidity and mortality, both in developed and developing countries.
- Trial name
- NCT00107874
- Testing
- misoprostol
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Surgical Site Infection
Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries
Pregnancy-associated infection represents a major cause of maternal morbidity and mortality. Cesarean delivery is the most common major surgical procedure and is associated with a rate of surgical site infection (SSI) that is…
- Trial name
- NCT04202471
- Testing
- Chlorhexidine Cloth
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Post Operative Pain
Too Much of a Good Thing? Impact of Initial Prescription Size in Post-cesarean Section Pain Management
This is a randomized controlled trial involving 170 opioid naive women ages 19-40 undergoing scheduled C-sections at Carilion Roanoke Memorial Hospital.
- Trial name
- NCT05360433
- Testing
- Oxycodone oral capsule
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Morbid Obesity, Cesarean Delivery Affecting Fetus
Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women
The objective of our study is to evaluate the effect of CPAP on umbilical cord acid base status in morbidly obese women at the time of scheduled cesarean delivery.
- Trial name
- NCT04993651
- Testing
- CPAP
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Eastern Virginia Medical School
Continuous Fetal Heart Beat Monitor and Analysis After Spinal Anesthesia
Fetal Heart Rate Pattern After Spinal Anesthesia for Scheduled Uncomplicated Cesarean Section
Spinal anesthesia may cause sympathetic blockade which decrease peripheral vascular resistance and bradycardia and then hypotension.
- Trial name
- NCT05776186
- Testing
- Spinal anesthesia with heavy bupivacaine
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital