Clinical trials: Schizo-Affective Type of Psychosis
First Episode Psychosis of Schizophrenia and Schizotypal Disorder, Psychotic Disorders
Extended Specialized Assertive Intervention for First Episode Psychosis
In a randomized clinical trial, the researchers want to investigate if the positive short-term outcomes (first 1-2 years), achieved with specialized assertive intervention programme (OPUS), can be maintained for five years if the…
- Conditions
- First Episode Psychosis of Schizophrenia and Schizotypal Disorder, Psychotic Disorders, Schizophrenia, Schizoaffective Disorder
- Trial name
- OPUSII (NCT00914238)
- Testing
- 2 years OPUS treatment, OPUS 5 years
- Where
- 2 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- University of Copenhagen
Schizophrenia, Schizoaffective Disorder, Mixed Type
Online HD-tDCS Over the Left DLPFC During a Working Memory Task for Treating Negative Symptoms of Schizophrenia
In this randomized double-blind trial, the investigators aim to investigate whether online high definition transcranial direct current stimulation (HD-tDCS) over the left dorsolateral prefrontal cortex (DLPFC) during a working…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Mixed Type, Negative Symptoms in Schizophrenia
- Trial name
- NCT05582980
- Testing
- HD-tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Schizophrenia, Schizoaffective Disorder
Pharmacokinetic Characterization of Intramuscular Olanzapine Depot
The goals of this study are to: Determine the blood levels of intramuscular (IM) olanzapine depot in patients at different points in time after an injection, and compare these levels to the amount of olanzapine in the blood of…
- Trial name
- NCT00094640
- Testing
- Intramuscular Olanzapine Depot
- Where
- 8 sites in Australia, Belgium and 6 more
- Sponsor
- Eli Lilly and Company
Psychosis, Schizophrenia
Service User and Staff Views on Digital Remote Monitoring for Psychosis
Psychosis is a severe mental health problem. Symptoms of psychosis include hallucinations (e.g. hearing voices that others cannot hear) and delusions (unusual, often troubling beliefs).
- Conditions
- Psychosis, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT05670197
- Testing
- No intervention. Participants will take part in a qualitative interview
- Where
- 6 sites in United Kingdom
- Volunteers
- 118 people
- Sponsor
- Manchester Academic Health Science Centre
Schizophrenia, Schizoaffective Disorder
Comparative Effectiveness of Adaptive Treatment Strategies for Schizophrenia
The study is a retrospective cohort study of adults with schizophrenia that will compare outcomes of new users of alternative psychotropic medication strategies using 10 years of Medicaid data.
- Trial name
- NCT02775864
- Testing
- Antipsychotic, Antidepressant, Benzodiazepine
- Volunteers
- 81,921 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Schizoaffective Disorder
A Comparison of Two Cognitive Batteries in People With Schizophrenia
The investigators will compare the test-retest reliabilities of two cognitive batteries in people with schizophrenia: Cognitive Drug Research Computerized Cognitive Assessment System ("CDR") and MATRICS Consensus Cognitive…
- Trial name
- NCT00499044
- Testing
- CDR Computerized Cognitive Assessment System, MATRICS Consensus Cognitive Battery
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- North Suffolk Mental Health Association
Schizophrenia and Schizoaffective Disorder, Bipolar Disorder (BD)
Survey on the Reproductive and Child-Rearing Situations of Patients With Severe Mental Disorders
Severe mental disorders represent a major public health concern, imposing substantial disease burden and adversely affecting multiple dimensions of patients' lives, while also creating intergenerational impacts on their offspring…
- Trial name
- NCT07005245
- Where
- China
- Volunteers
- 77,145 people
- Sponsor
- Peking University
Obesity, Vitamin D Deficiency
Vitamin D Supplementation in Psychiatric Illnesses
Children and adolescents with psychiatric illnesses who are treated with medications called second generation antipsychotic agents (SGA) often gain excessive weight during their treatment with these medications.
- Conditions
- Obesity, Vitamin D Deficiency, Psychosis, Schizophrenia
- Trial name
- VDSS (NCT01004354)
- Testing
- Ergocalciferols
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Massachusetts, Worcester
Psychotic Disorders, Depressive Disorder, Major
Treatment of Schizoaffective Disorder Using Mifepristone
This study tests the hypothesis that mifepristone will diminish cognitive distortion and alleviate psychosis in patients with schizoaffective disorder.
- Conditions
- Psychotic Disorders, Depressive Disorder, Major, Depressive Disorder
- Trial name
- NCT00725270
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Schizophrenia, Schizoaffective Disorder
The Efficacy of Metacognitive Skills Training in the Context of Forensic Psychiatric Care
Deficiencies in social cognition are part of the core symptomatology of psychotic disorders. And deficiencies in social cognition, the closely related concept of metacognition, and, for example, paranoid attitudes are all…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorders, Delusional Disorder
- Trial name
- NCT06005766
- Testing
- Metacognitive Skills Training (MCT), Treatment as usual
- Where
- Finland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Schizophrenia, Schizoaffective Disorder
Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with…
- Trial name
- REVISIT-C (NCT05208190)
- Testing
- Clozapine, treatment as usual
- Where
- 7 sites in United States
- Volunteers
- 280 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Schizoaffective Disorder
Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder
The purpose of this research study is to determine whether a new drug for schizophrenia is better for the maintenance treatment than a standard drugs currently prescribed.
- Trial name
- NCT00018642
- Testing
- quetiapine, haloperidol decanoate
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizoaffective Disorder
A Clinical Trial to Examine Effects of Atomoxetine in the Treatment of Negative Symptoms in Patients With Schizophrenia
This study proposes to examine the effect of atomoxetine on quality of life and negative symptoms such as social withdrawal, lack of interest in things, lack of thought content, flat emotions, slowed body movements and lack of…
- Trial name
- NCT00222794
- Testing
- Atomoxetine (Strattera)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Pittsburgh
DSM-IV Schizophrenia, Schizoaffective Disorder
Evaluation of the Strategies of Switching Schizophrenia Patients to Aripiprazole From Other Antipsychotic Agents
The purpose of this study is to determine whether moderately ill Asian schizophrenic patients can be switched from their previous antipsychotic medication to aripiprazole with minimal adverse clinical consequences, and elucidate…
- Trial name
- NCT00545467
- Testing
- Aripiprazole
- Where
- Taiwan
- Volunteers
- 79 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Schizoaffective Disorder
F-18 Altanserin PET Study of Patients Receiving Clozapine
To examine the feasibility of molecular imaging markers in clinical psychopharmacology
- Trial name
- APC (NCT01398189)
- Testing
- clozapine
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Bundang Hospital
Schizophrenia, Schizoaffective Disorder
Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin
This study supplements patients' current medications with Pravastatin, a cholesterol-lowering medication, to try to improve residual symptoms of schizophrenia, and also to improve cognitive functioning.
- Trial name
- NCT00177580
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pittsburgh
Schizophrenia, Bipolar Disorder
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
The purpose of this study is to better understand mental illness and will test the hypotheses that, while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after…
- Conditions
- Schizophrenia, Bipolar Disorder, Healthy, Psychosis
- Trial name
- GABAmech (NCT04004416)
- Testing
- Lorazepam and fMRI
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Schizophrenia, Schizotypal Disorder
Feasibility and Relevance of High-Intensity Functional Training in Patients With First-Episode Psychosis
The aim of the COPUS study is to investigate, whether it is possible to recruit and retain young people with first-episode psychosis, to an 8 week supervised High-Intensity Functional Training intervention (HIFT) (i.e.
- Conditions
- Schizophrenia, Schizotypal Disorder, First Episode Psychosis, Psychotic Disorders
- Trial name
- COPUS (NCT03409393)
- Testing
- The COPUS intervention, Usual Care (OPUS treatment)
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Schizophrenia
Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.
This application seeks renewed support for MH59803, "Dopaminergic substrates of startle gating across species," to extend a clear path of "bench-to-bedside" progress towards a critical paradigm shift in therapeutic models for…
- Trial name
- NCT02634684
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mental Disorder, Personality Disorders
Implementation, Efficacy and Costs of Inpatient Equivalent Home-Treatment in German Mental Health Care
The "inpatient-equivalent home treatment"(IEHT) according to §115d SGB-V is a particular version of the internationally well-known and evidence-based Home Treatment.
- Conditions
- Mental Disorder, Personality Disorders, Schizo Affective Disorder, Anxiety Disorders
- Trial name
- AKtiV (NCT04745507)
- Testing
- Inpatient Equivalent Home Treatment
- Where
- 10 sites in Germany
- Volunteers
- 629 people
- Sponsor
- Vivantes Netzwerk für Gesundheit GmbH