Clinical trials: Schizophrenia (Recent-onset)
Schizophrenia
Aripiprazole Once-monthly Versus Daily Oral Atypical Antipsychotic Treatment in Patients With Recent-onset Schizophrenia
This is an observational, non-interventional study that will include two cohorts of patients with schizophrenia who initiated maintenance treatment during a schizophrenia-related hospitalisation or during the immediate three…
- Trial name
- NCT03130465
- Where
- 67 sites in France, Germany and 2 more
- Volunteers
- 636 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Psychotic Disorders
Cognitive Behavioural Therapy- Social Functioning In Adolescence With Recent Onset Schizophrenia
Rationale: There is growing consensus that targeting negative symptoms such as social withdrawal is essential to be able to preserve social participation, thereby reducing the high yearly costs of schizophrenia. Aaron T.
- Trial name
- Social (NCT03217955)
- Testing
- CBT-SA, Standard Treatment
- Volunteers
- 98 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Psychotic Disorders, Recent-Onset Psychosis
Effects of a Peer-facilitated, Acceptance-based Self-learning for Illness Management (PASIM) Program
Psychosis is a very disabling mental illness with a wide range of dysregulations and disruptions in cognition, emotions, and behaviors, resulting in poor functioning and frequent relapses, especially in the first five years of…
- Trial name
- NCT07129369
- Testing
- PASIM program, Psychoeducation, Usual-Care-only
- Where
- 2 sites in China
- Volunteers
- 186 people
- Sponsor
- Chinese University of Hong Kong
Schizophrenia, Psychotic Disorder
tDCS for Cognitive Impairment Associated With Recent-onset Schizophrenia
Background: In parallel to the traditional symptomatology, deficits in cognition (memory, attention, reasoning, social functioning) contribute significantly to disability and suffering in individuals with schizophrenia.
- Trial name
- STICOG (NCT05440955)
- Testing
- left fronto-temporal transcranial Direct Current Stimulation (tDCS)
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Recent-Onset Psychosis, Schizophrenia
Multifamily Psychoeducation and Cognitive Remediation for Recent-Onset Psychosis
The goal of this study is to determine whether pairing multifamily group psychoeducation with cognitive remediation may facilitate improved outcomes among individuals with recent-onset psychosis.
- Conditions
- Recent-Onset Psychosis, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder With Psychotic Features
- Trial name
- NCT01196286
- Testing
- Multifamily Group Psychoeducation (MFG), Cognitive Remediation (CR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Psychosis
Efficacy of Social Cognitive Training (SCT) in Recent-onset Psychosis
Participants with recent onset psychosis (ROP) experience delusions, hallucinations, and impairment in social, cognitive and emotional functioning.
- Trial name
- NCT03962426
- Testing
- SocialVille Social Cognitive Training
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Schizophrenia
Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia
The aim of this study is to investigate the efficacy of neuroscience-guided computerized cognitive training exercises on the remediation of cognitive deficits and symptoms associated with recent-onset schizophrenia and to examine…
- Trial name
- NCT00694889
- Testing
- Neuroadaptive cognitive training, Computer games
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Francisco
Schizophrenia (Recent-onset)
Oral Risperidone Versus Injectable Paliperidone Palmitate for Treating First-Episode Schizophrenia
This study will determine the efficacy of oral risperidone (Risperdal) versus long-acting injectable paliperidone palmitate (Invega Sustenna) in treating people with first-episode schizophrenia.
- Trial name
- NCT01451736
- Testing
- paliperidone palmitate, risperidone
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Early Psychosis, Psychotic Disorders
Effects of an Acceptance-based Medication Adherence Therapy for Recent-onset Psychosis
This randomized controlled trial aimed to examine the effectiveness of a 10-session acceptance-based, insight-inducing medication adherence therapy (AIM-AT) program for recent-onset psychosis (in addition to usual care) over a…
- Trial name
- AIM_AT (NCT06192602)
- Testing
- AIM_AT, CPG, TAU
- Where
- Hong Kong
- Volunteers
- 126 people
- Sponsor
- Chinese University of Hong Kong
Schizophrenia
Treating Schizophrenia by Correcting Abnormal Brain Development
The purpose of this study is to determine whether treatment with tiagabine (Gabitril) during the early course of schizophrenia can fundamentally correct the brain deficits associated with the disease.
- Trial name
- NCT00179465
- Testing
- Tiagabine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Beth Israel Deaconess Medical Center
Schizophrenia
Impact of Structural and Myelin Abnormalities on Cognitive Impairments in Recent-onset Schizophrenia - Before and After Lurasidone Treatment (MARYLU)
The present longitudinal study aims to investigate the impact of lurasidone treatment in recent-onset psychosis patients. The effects of lurasidone will be studied primarily in terms of structural and myelin modifications, in…
- Trial name
- MARYLU (NCT05351736)
- Testing
- Lurasidone
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Schizophrenia
Effectiveness of Aripiprazole Long-acting Injection in Recent Onset and Chronic Schizophrenia Patients
The aim of the study is to investigate the effectiveness of Aripiprazole long-acting injection in recent onset and chronic schizophrenia patients
- Trial name
- NCT03839251
- Testing
- abilify maintena
- Where
- 5 sites in South Korea
- Volunteers
- 82 people
- Sponsor
- Chonbuk National University Hospital
Schizophrenia, Schizophreniform Disorder
Pregnenolone Augmentation in the Treatment of Patients With Recent-Onset Schizophrenia
Pregnenolone (PREG) is a neurosteroid, which displays multiple effects on the central nervous system, and may be beneficial in the treatment of patients with schizophrenia.
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorders
- Trial name
- PREG-2008 (NCT00847600)
- Testing
- Pregnenolone
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Schizophrenia
Continued Early Intervention for Recent-onset Schizophrenia
The purpose of this study was to determine whether outreach integrated treatment of first episode schizophrenia was more effecive than standard outpatient treatment.
- Trial name
- NCT00184509
- Testing
- integrated psychosocial treatment (behavior)
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Norwegian University of Science and Technology
Schizophrenia
High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia
The purpose of this study is to compare efficacy and safety of add-on treatment with a moderately high dose of D-serine, an NMDA-glycine site agonist, in young, recent onset schizophrenia patients who suffer from significant…
- Trial name
- SATROS (NCT01459029)
- Testing
- D-serine
- Where
- 2 sites in Israel
- Volunteers
- 54 people
- Sponsor
- Hadassah Medical Organization
Schizophrenia, Schizoaffective Disorder
Prednisolone Addition for Patients With Recent-onset Psychotic Disorder
Treatment with prednisolone can be used as a proof of concept to investigate the possibility of immune modulation as a treatment for schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychotic Disorder NOS
- Trial name
- NCT02949232
- Testing
- Prednisolone
- Where
- 4 sites in Belgium, Denmark and 1 more
- Volunteers
- 42 people
- Sponsor
- UMC Utrecht