Clinical trials: Schizophrenia Disorder
Schizophrenia
Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Original Study
This trial is designed to determine if administering repetitive transcranial magnetic stimulation (rTMS) simultaneously to two sites in the temporal lobes, one on the left and one on the right, produces greater improvements in…
- Trial name
- NCT00567281
- Testing
- Magstim Rapid 2 system triggering Magstim Super Rapid system, Magstim Rapid-2 system triggering Magstim Super Rapid system
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Psychosis
Strengthening Care in Collaboration With People With Lived Experience of Psychosis in Uganda
Background: Mental health services are most effective and equitable when designed, delivered, and evaluated in collaboration with people with lived experience of mental health conditions.
- Trial name
- SCAPE-U (NCT05863572)
- Testing
- Primary care health worker training, Community Health Workers Training, Home visits
- Where
- Uganda
- Volunteers
- 179 people
- Sponsor
- George Washington University
Schizophrenia
Cognitive Remediation Therapy in Schizophrenia: Effects on Epigenetics
This study is a randomised and controlled trial that aims to investigate whether Cognitive Remediation Therapy (CRT) can modulate epigenetic mechanisms by changing methylation levels of BDNF gene in patients with Schizophrenia.
- Trial name
- NCT04278027
- Testing
- Cognitive Remediation Therapy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Schizophrenia, Exercise
Comparison of the Effects of Aerobic Exercise and Computerized Cognitive Stimulation in Patients With Schizophrenia - A Randomized Controlled Trial
Schizophrenia is a chronic mental disorder characterized by the occurrence of both positive symptoms, such as hallucinations and delusions, and negative symptoms, such as apathy and withdrawal, repetition of cognitive skills and…
- Conditions
- Schizophrenia, Exercise, Computerized Cognitive Stimulation
- Trial name
- NCT06572657
- Testing
- cognitive stimulation, physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Schizophrenia
Proof of Concept Study of Cognitive Improvement in Patients With Schizophrenia
The purpose of this study is to demonstrate that AZD3480 improves cognition in patients with stable schizophrenia who are being treated with an atypical antipsychotic and who are active cigarette smokers, to assess the safety and…
- Trial name
- HALO (NCT00528905)
- Testing
- AZD3480
- Where
- 80 sites in United States, Canada
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
Schizophrenia
Functional Neuroimaging Effects of Cognitive Remediation Training
The purpose of this study is to examine behavioral and functional brain changes occuring as a result of cognitive remediation training in patients with schizophrenia.
- Trial name
- NCT00481156
- Testing
- Cognitive Remediation, Cognitive Behavioral Social Skills Training, Retest in Health Controls
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia
Pharmacokinetic Study of MIN-101 in Healthy Subjects
The aim of the study is to assess how MIN-101 is taken up by the body when given in different amounts and in different formulations.
- Trial name
- NCT02232529
- Testing
- MIN-101
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Minerva Neurosciences
Schizophrenia and Related Disorders
Role of an E-cigarette on Smoking Displacement in Smokers With Schizophrenia
It is well established in the scientific literature that people with schizophrenia smoke tobacco cigarettes at rates up to three times that of the general population, relapse more frequently, and die an average of 25 years…
- Trial name
- NCT03075202
- Testing
- e-cigarette, brand name JUUL
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Schizophrenia
A Study to Evaluate the Effect of KarXT on Urological Safety
The purpose of this study is to characterize the effect of KarXT on voiding dynamics and urological safety in participants with DSM-5 schizophrenia.
- Trial name
- NCT07221877
- Testing
- Xanomeline/trospium chloride
- Where
- 16 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
Schizophrenia, Sleep
Effect of Olanzapine on Sleep Electroencephalogram (EEG) in Schizophrenia Patients
Acute and sub-chronic administration of olanzapine has shown a favourable effect on the sleep disturbances in previously medicated schizophrenia patients with predominantly negative symptoms.
- Trial name
- NCT01149577
- Testing
- Olanzapine
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Schizophrenia, Schizoaffective Disorder
Switching Antipsychotics: Abrupt Discontinuation Versus Overlap
Clozapine has been demonstrated to be clinically superior to other antipsychotics in treatment-resistant schizophrenia (TRS), and is positioned as such in treatment guidelines.
- Trial name
- NCT02640300
- Testing
- Clozapine
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia Disorder
AI-assisted Masticatory Muscle Training in Patients With Schizophrenia
Dysphagia seems to be quite common and potentially severe in schizophrenia, which may lead to acute asphyxia or pneumonia. Dysphagia in schizophrenia could be associated with drug-induced Parkinsonism, dystonia, tardive…
- Trial name
- AI-assisted (NCT07154407)
- Testing
- AI-assisted Mastisting Training App
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Severe Mental Illness, Rehabilitation
Using Clinical Process Indicators, Patient Reported Outcome Measures (PROMs), and Patient Reported Experience Measures (PREMs) to Improve the Quality and Continuity of Care for Psychiatric Patients
The objective of the proposed study is to take a further step in this direction by developing, implementing and monitoring a routine systematic evaluation of clinical process and outcome indicators, patient reported experience…
- Conditions
- Severe Mental Illness, Rehabilitation, Schizophrenia
- Trial name
- PROM-PREM (NCT04314154)
- Testing
- Monitoring PROM @ PREM data on participating patients
- Where
- Israel
- Volunteers
- 125 people
- Sponsor
- Shalvata Mental Health Center
Emotional Dysregulation
Patients Suffering From Emotional Dysregulation
Emotional dysregulation (ED) is a common syndrome in psychiatric disorders. It is characterized by intense emotions, easily triggered, and with significant psychological impact: explosions of anger, irritability, impulsivity…
- Trial name
- Dys-Emotion (NCT06616337)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Schizophrenia
Schizophrenia Sensory Gating Deficit With Quetiapine
The purpose of this study is the use of magnetoencephalography or MEG (a machine that measures magnetic activity in your brain) and electroencephalography or EEG (a technique that measures electrical activity in your brain) to…
- Trial name
- NCT00536783
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New Mexico VA Healthcare System
Schizophrenia, Bipolar Disorder
Real-Time Mobile Cognitive Behavioral Intervention for Serious Mental Illness
The purpose of this study is to evaluate the effectiveness of a mobile real-time cognitive behavioral intervention for serious mental illness (SMI) and to identify the facilitators, barriers, and costs of implementation.
- Trial name
- NCT02035202
- Testing
- CBT2go, Smartphone
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of California, San Diego
Psychotic Disorders
Irish Omega-3 Study
The Irish Omega-3 study is a clinical trial designed to investigate the potential of Omega-3 fatty acids in the reduction of risk of psychosis.
- Trial name
- NCT02848469
- Testing
- 1000mg of eicosapentaenoic acid and 1000mg docosahexaenoic acid
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- University College Cork
Mania, Schizophrenia
Unraveling the Relation of Patient's Profile and Therapeutical Effects of Atypicals, Including Quetiapine Effect
With this observational study we want to examine if the intensity of agitation, the intensity of psychotic symptoms and the presence of sleeping disorder predict the success of the treatment with a atypical antipsychotic after 12…
- Trial name
- UPTAQE (NCT00534222)
- Where
- 6 sites in Netherlands
- Volunteers
- 387 people
- Sponsor
- AstraZeneca
Schizophrenia
Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids
This research study helps to demonstrate that adding vitamins and fats (nutritional supplements) to a diet will help reduce body weight and improve the lipid profile.
- Trial name
- NCT00211562
- Testing
- Olanzapine, Omega 3, Vitamin E+C
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Augusta University
Schizophrenia, Treatment-resistant Schizophrenia
Neural Biomarkers of Clozapine Response
Clozapine has consistently shown to be a superior drug for psychosis in patients who do not respond to other treatments, but its mechanism of action remains unknown.
- Conditions
- Schizophrenia, Treatment-resistant Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT03076346
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pittsburgh