Clinical trials: Schizophrenia Disorders
Schizophrenia, Mood Disorders
"Art Therapy" in Acute Psychiatry
Background: Given the complexity of this problem, psychiatric in-patients in the acute stage of their disease need different types of therapeutic programs to recover they mental health state.
- Conditions
- Schizophrenia, Mood Disorders, Mental Disorder, Nurse-Patient Relations
- Trial name
- NCT03575442
- Testing
- 3 session program of "art therapy"
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Schizophrenia, Schizoaffective Disorder
Glucose and Lipid Metabolism on Antipsychotic Medication
This project aims to a) evaluate the effects of selected antipsychotic medications on insulin action in skeletal muscle (glucose disposal), liver (glucose production) and adipose tissue (whole-body lipolysis), b) evaluate the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Type 2 Diabetes Mellitus, Hyperglycemia
- Trial name
- Glulipid (NCT00515723)
- Testing
- risperidone, olanzapine, quetiapine
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Washington University School of Medicine
Schizophrenia Spectrum and Other Psychotic Disorders
Metacognitive Training and Insight in Schizophrenia
Although insight in schizophrenia spectrum disorders (SSD) has been associated with positive outcomes, the effect size of previous treatments on insight has been relatively small to date.
- Trial name
- MCT-I (NCT04104347)
- Testing
- Metacognitive training (MCT), Support group
- Where
- Spain
- Volunteers
- 252 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Supported Accommodation Residents, Schizophrenia, Shizotypal and Delusional Disorders
Quantitative Investigation of Environment and Participation
Supported accommodation provides individuals with complex mental health difficulties the opportunity to maintain a tenancy with different levels of staff support provided to develop and maintain living skills and engage in social…
- Conditions
- Supported Accommodation Residents, Schizophrenia, Shizotypal and Delusional Disorders, Mood Affective Disorders, Disorders of Adult Personality and Behavior
- Trial name
- QIEP (NCT04106960)
- Testing
- No Intevention Used
- Where
- United Kingdom
- Volunteers
- 235 people
- Sponsor
- Queen Margaret University
Schizophrenia, Schizoaffective Disorder
Neuroendocrine and Immune Response to Stress in Schizophrenia
This is a pilot study. We are testing the physiologic, immune and chemical responses to stress. We believe the results of all measures to stress will be blunted in schizophrenia compared to healthy controls.
- Trial name
- TSST (NCT01975584)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Biomarker Study of Acamprosate in Schizophrenia
NMDA receptors are brain receptors that are stimulated by glutamate. Poorly functioning NMDA receptors are thought to be involved in the pathology of schizophrenia.
- Trial name
- NCT00688324
- Testing
- Acamprosate
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Oxytocin and CBSST for People With Schizophrenia
A significant proportion of people with schizophrenia are characterized by impaired ability to socially engage with others, which may reflect social aversion secondary to defeatist beliefs; decreased motivation for social…
- Trial name
- NCT01752712
- Testing
- CBSST + Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Maryland, Baltimore
Bipolar I Disorder, Unspecified, With Psychotic Features, Bipolar I Disorder, Unspecified, Without Psychotic Features
Psychosis and Affective Research Domains and Intermediate Phenotypes
The objective of this multi-site research collaboration is to test the manifestation and distribution of biological markers for psychosis and affect dimensions across the schizophrenia/bipolar (SZ-BD) diagnostic boundary, and to…
- Trial name
- PARDIP (NCT02218853)
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Schizophrenia, Psychosis
Community-Based Cognitive Training in Early Schizophrenia
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset schizophrenia, schizoaffective, schizophreniform, and psychosis NOS who are…
- Trial name
- COTES (NCT01973270)
- Testing
- Neuroadaptive cognitive training
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of California, San Francisco
Schizophrenia, Schizoaffective Disorder
Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia
Schizophrenia is marked by problems in attention, memory and problem solving. These deficits predict long-term functional outcome such as the ability to live independently and maintain employment, but they are not ameliorated by…
- Trial name
- NCT02069392
- Testing
- Cognitive remediation training, Nicotine polacrilex lozenge
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder
The purpose of this study is to investigate the effect of Lu AF35700 on electrical activity in the heart as measured on an electrocardiogram (ECG) in patients with schizophrenia or schizoaffective disorder after 6 weeks of…
- Trial name
- NCT02901587
- Testing
- Lu AF35700 (10 mg/day), Lu AF35700 (30 mg/day), Quetiapine (Seroquel XR® 800 mg/day)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- H. Lundbeck A/S
Schizophrenic Disorders
Have a Good Grasp of the Worldthe World
Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible.
- Trial name
- GRASP (NCT02655172)
- Testing
- cognitive tasks + PANSS+ IQ, cognitive tasks
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Schizophrenia, Major Depression
Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core
Background: The Human Brain Collection Core (HBCC) collects brain and other tissues. They get these from deceased people who may or may not have had psychiatric disorders.
- Conditions
- Schizophrenia, Major Depression, Bipolar Disorder, PTSD
- Trial name
- NCT03092687
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Schizophrenia
Antipsychotics and Blood Vessel Function
Over the last decade, second generation antipsychotics have been increasingly utilized. Since their introduction, however, atypical antipsychotics have been increasingly associated with significant metabolic complications…
- Trial name
- NCT00585273
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Jess G. Fiedorowicz
Schizophrenia, Mental Illness
A Research in Pharmacogenomics and Accurate Medication of Risperidone
Risperidone is a selective monoamine receptor antagonist. It plays an antipsychotic effect by antagonizing 5-HT2 / D2 receptor. As a second-generation antipsychotic drug, risperidone is metabolized to 9-hydroxy Risperidone in the…
- Trial name
- NCT03302364
- Testing
- Risperidone
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Cui Yimin
Schizophrenia, Schizoaffective Disorder
Adjunctive Treatment for Decreasing Symptoms of Schizophrenia
This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patients with schizophrenia.
- Trial name
- NCT00222235
- Testing
- d-cycloserine, glycine
- Where
- 5 sites in United States, Israel
- Volunteers
- 240 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
In this study, we will compare cue-reactivity in smokers with and without schizophrenia and the influence of smoking cues on responding for cigarette puffs under a PR schedule of reinforcement.
- Trial name
- NCT00770237
- Testing
- Smoking Cues, Neutral Cues
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Substance Abuse
Screening Protocol for Research Participants
The Screening Protocol is a system devised to evaluate potential research participants for National Institute on Drug Abuse/Maryland Psychiatric Research Center (NIDA/MPRC) studies.
- Conditions
- Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
- Trial name
- ScreenProt (NCT01010620)
- Testing
- Various Screening psychiatric and medical assessments
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Schizophrenia and the Gut Microbiome
In a sample of 20 inpatients with a DSM-IV-TR/DSM 5 diagnosis of schizophrenia or schizoaffective disorder, investigators propose to conduct a prospective, 2 week observational trial to collect gastrointestinal stool samples in…
- Trial name
- NCT02921243
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Nicotine Dependence
Music to Reduce Use of Smoking in Patients With Schizophrenia
The purpose of this study is to explore the impact of self-selected music listening which targets disrupting the reward process maintaining smoking and additionally attenuating the reward processing deficits associated with…
- Conditions
- Schizophrenia, Nicotine Dependence, Smoking, Tobacco
- Trial name
- NCT03190161
- Testing
- Music session
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health