Clinical trials: Schizophrenia and Disorders With Psychotic Features
Schizophrenia
Effect of Daily Short Message System (SMS) Reminders on Medication Adherence to Oral Antipsychotics in Patients With Schizophrenia
This study is a 6-month, multicenter, randomized study to assess the effect of daily SMS reminders sent during 3 months in the adherence to oral antipsychotic treatment in stabilized outpatients with schizophrenia.
- Trial name
- SMS (NCT00873249)
- Where
- 25 sites in Spain
- Volunteers
- 339 people
- Sponsor
- AstraZeneca
Schizophrenia
A Pharmacokinetic and Safety Study of Risperidone Long Acting Injectable in Schizophrenic Patients
The purpose of this study is to explore the pharmacokinetic profile and safety after biweekly (every 2-week) intramuscular (IM) injections (6 injections) of risperidone long acting injectable 25, 37.5, or 50 mg/dose in…
- Trial name
- NCT00653406
- Testing
- Risperidone long acting injectable
- Volunteers
- 29 people
- Sponsor
- Janssen Pharmaceutical K.K.
Schizophrenia Patients
Intermittent Theta-Burst Stimulation to Improve Negative Symptoms and Cognition in Schizophrenia
The planned randomized, sham-controlled, double-blind, monocentric study aims to evaluate the effectiveness of intermittent Theta-Burst Stimulation (iTBS) on negative symptoms and cognitive deficits in schizophrenia.
- Trial name
- ITBS-NKS-2024 (NCT06740747)
- Testing
- Intermittent theta-burst stimulation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Bipolar Disorder (BD), Schizophrenia Disorders
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved…
- Conditions
- Bipolar Disorder (BD), Schizophrenia Disorders, Major Depressive Diorder, Dementia
- Trial name
- GlobalMinds (NCT06641726)
- Testing
- Not applicable- observational study
- Where
- United Kingdom
- Volunteers
- 50,000 people
- Sponsor
- Akrivia Health
Mental Disorders, Mood Disorders
Resource-oriented Music Therapy for Psychiatric Patients With Low Therapy Motivation
The aim of this study is to examine whether resource-oriented music therapy helps psychiatric patients with low therapy motivation to improve negative symptoms and other health-related outcomes.
- Conditions
- Mental Disorders, Mood Disorders, Personality Disorders, Schizophrenia and Disorders With Psychotic Features
- Trial name
- NCT00137189
- Testing
- Resource-oriented music therapy, Standard care
- Where
- 5 sites in Australia, Austria and 1 more
- Volunteers
- 144 people
- Sponsor
- NORCE Norwegian Research Centre AS
Schizophrenia
Augmenting Clozapine With Sertindole - SERCLOZ
The purpose of the study is to determine whether addition of sertindole to clozapine treatment can improve psychosis or the metabolic side-effects of clozapine in patients with treatment-resistant schizophrenia.
- Trial name
- NCT00345982
- Testing
- Serdolect
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Schizophrenia, Schizoaffective Disorder
Brain Imaging, Cognitive Enhancement and Early Schizophrenia
The proposed project is designed to examine the effects of cognitive rehabilitation on brain structure and function in a randomized trial of 102 early course schizophrenia patients treated for 18 months with either cognitive…
- Trial name
- BICEPS (NCT01561859)
- Testing
- Cognitive Enhancement Therapy, Enriched Supportive Therapy
- Where
- 5 sites in United States
- Volunteers
- 102 people
- Sponsor
- Beth Israel Deaconess Medical Center
Schizophrenia, Schizoaffective Disorder
Prebiotic Treatment in People With Schizophrenia
The proposed project is based on the observation that schizophrenia is characterized by a chronic pro-inflammatory state, which contributes to the severity of a number of the clinical manifestations of the illness, including…
- Trial name
- FOCIS (NCT05527210)
- Testing
- Prebiotic
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Bipolar Disorder, Schizophrenia
Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder
This is an in-clinic, single arm, open-label study assessing tachyphylaxis, tolerance, and withdrawal following repeated doses of Igalmi in adult males and females with agitation associated with schizophrenia or bipolar disorder.
- Conditions
- Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder
- Trial name
- NCT06041646
- Testing
- Sublingual film containing Igalmi
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- BioXcel Therapeutics Inc
Schizophrenia; Psychosis, Schizophrenia and Related Disorders
Accelerated rTMS for Psychomotor Slowing
The goal of this clinical trial is to optimize the treatment of psychomotor slowing in patients with schizophrenia using Transcranial Magnetic Stimulation (TMS).
- Conditions
- Schizophrenia; Psychosis, Schizophrenia and Related Disorders, Schizo Affective Disorder, Brief Psychotic Disorder
- Trial name
- ATMSSlowing (NCT06134661)
- Testing
- cTBS (continuous Theta Burst Stimulation)
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Bern
Schizophrenia, Schizophrenia Relapse
10-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals
This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the ten years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with…
- Conditions
- Schizophrenia, Schizophrenia Relapse, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- ADARFEP_10Y (NCT03090490)
- Testing
- Antipsychotic treatment discontinuation, Maintenance treatment discontinuation
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Fundación Marques de Valdecilla
Mental Disorders, Schizophrenia
Web-Based Weight Management for Individuals With Mental Illness
Obesity and physical inactivity have become serious problems for individuals with mental illness, resulting in increased rates of chronic disease, premature death, and substantial health care costs.
- Conditions
- Mental Disorders, Schizophrenia, Affective Disorders, Psychotic, Overweight
- Trial name
- eWellness (NCT01324973)
- Testing
- eWellness
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Schizophrenia
Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia
This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled.
- Trial name
- rTMS-FPCC (NCT04309370)
- Testing
- 20 Hz rTMS
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Schizophrenia, Schizoaffective Disorder
Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia
The aim of the proposed pilot study is to find out whether varenicline (ChantixTM) treatment decreases alcohol use and smoking in patients with schizophrenia or schizoaffective disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Alcohol Dependence, Nicotine Dependence
- Trial name
- NCT00727103
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Upstate Medical University
Schizophrenia Spectrum and Other Psychotic Disorders
Testing a New Device to Advance the Use of Social Skills Training With Mental Health Consumers and Clinicians
This study aims to test a new device called the Social Skills Coach that is being created to help mental health consumers with social skills and community functioning.
- Trial name
- SST (NCT03053557)
- Testing
- Social Skills Coach
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Schizophrenia
A Clinical Pharmacology Trial of Brexpiprazole Long Acting Injectable (LAI) Administered as a Single Dose in Patients With Schizophrenia
The purpose of this study is to determine the pharmacokinetics (PK), tolerability and safety of brexpiprazole LAI following a single administration in subjects with schizophrenia.
- Trial name
- NCT05119894
- Testing
- Brexpiprazole LAI: Dose 1, Brexpiprazole LAI: Dose 2, Brexpiprazole LAI: Dose 3
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Schizophrenia
Trial to Investigate the Safety and Efficacy of GWP42003-P Versus Placebo as Adjunctive Therapy in Participants With Schizophrenia Experiencing Inadequate Response to Ongoing Antipsychotic Treatment
This study will be conducted to evaluate the efficacy, safety, and tolerability of GWP42003-P versus placebo in participants with schizophrenia experiencing inadequate response to ongoing antipsychotic treatment.
- Trial name
- NCT04421456
- Testing
- GWP42003-P
- Where
- 39 sites in United States, Poland and 2 more
- Volunteers
- 95 people
- Sponsor
- Jazz Pharmaceuticals
Schizophrenia
Observational Study of Long Acting Injectable Medications (LAIs) in Schizophrenia (OASIS)
The objectives of this study are to describe characteristics, treatment patterns, and outcomes of patients with schizophrenia newly initiated on 1 of 4 FDA-approved atypical Long Acting Injectable (LAI) antipsychotics (ABILIFY…
- Trial name
- NCT03919994
- Where
- 57 sites in United States
- Volunteers
- 338 people
- Sponsor
- Alkermes, Inc.
Schizophrenia
Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)
The purpose of this study is to understand treatment preference and satisfaction among adults with schizophrenia in the United States who are prescribed xanomeline and trospium chloride (X/T) therapy
- Trial name
- NCT07101094
- Testing
- xanomeline and trospium chloride (X/T) therapy
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bristol-Myers Squibb
Schizophrenia
Long-Term Study of MP-214 in Patients With Schizophrenia
The objective of this study is to evaluate the long-term safety, tolerability, and efficacy of MP-214 in patients with schizophrenia.
- Trial name
- NCT01626872
- Testing
- MP-214 3mg, MP-214 6mg, MP-214 9mg
- Where
- 3 sites in Japan, South Korea and 1 more
- Volunteers
- 254 people
- Sponsor
- Tanabe Pharma Corporation
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