Clinical trials: Schizophrenia and Disorders With Psychotic Features
Mental Disorders, Schizophrenia
STIM'ZO : Examining tDCS as an add-on Treatment for Persistent Symptoms in Schizophrenia
This project aims to provide the proof of concept for transcranial direct-current stimulation (tDCS) in the treatment of resistant/persistent Schizophrenia symptoms.
- Trial name
- STIM'ZO (NCT02744989)
- Testing
- Neuroconn or Neuroelectric tDCS stimulator
- Where
- 10 sites in France, Monaco
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Schizophrenia, Schizoaffective Disorder
Building Employment Skills Through Therapy for Veterans
Schizophrenia/Schizoaffective Disorder is associated with serious problems with cognitive skills, social skills, and functional skills (like employment).
- Trial name
- BESTVet (NCT01992913)
- Testing
- integrated Cognitive Behavioral Therapy, Usual Care, Computerized cognitive remediation (CCR)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Constipation
Effects of Psyllium on Constipation in Schizo-phrenic: A Randomized Controlled Crossover Trial
Constipation in schizophrenia is an important issue in clinical care. Constipation needs psychiatric professionals concerning and providing intervention because it may cause ileus and lead to death.
- Trial name
- NCT05528146
- Testing
- Psyllium huks
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Hungkuang University
Schizophrenia
Mindfulness and Cognition in Schizophrenia
Mindfulness (innovative and integrative practice in care) allows the individual to adapt his/her behavior (physical and emotional), in a stressful environment, by regulating cardiac activity, especially the parasympathetic…
- Trial name
- NCT03318640
- Testing
- Mindfulness
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Auditory Hallucination, Hearing Voices When No One is Talking
Imagery Interventions for Auditory Vocal Hallucinations
This study explores the feasibility, acceptability, and effectiveness of four imagery intervention techniques (metacognitive imagery intervention, imagery rescripting, promoting positive imagery and competing imagery task) for…
- Conditions
- Auditory Hallucination, Hearing Voices When No One is Talking, Psychosis
- Trial name
- NCT05603260
- Testing
- Imagery intervention for voice hearing (meta-cognitive imagery rescripting), Imagery intervention for voice hearing (Imagery rescripting), Imagery intervention for voice hearing (promoting positive imagery de novo)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Hella Janssen
Schizophrenia, Schizoaffective Disorder
Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis
This study will assess the effectiveness of an experimental treatment intervention for adolescents and adults who have experienced their first episode of psychosis during the past two years.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Delusional Disorder
- Trial name
- NCT01216891
- Testing
- Multi-element, team-oriented treatment
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Schizophrenia
Safety and Effectiveness of D-serine in Schizophrenia
This study will determine whether increasing D-serine within the body will improve negative symptoms and cognitive impairments in people with schizophrenia.
- Trial name
- NCT00322023
- Testing
- D-serine
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Schizophrenia
Study in Stabilized Schizophrenic Patients to Evaluate the Pharmacokinetics of Risperidone and 9-Hydroxy (OH)-Risperidone When Risperidone is Administered From a Polyurethane Implant
This is an study evaluating the safety, tolerability, and PK of EN3342 in implantation durations of 6 months.
- Trial name
- NCT01774435
- Testing
- EN3342
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Schizophrenia
Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia
The purpose of this study is to assess how oxytocin delivered intranasally changes regional brain blood flow measured by positron emission tomography (PET) in conjunction with oxygen-15 labeled water in persons with…
- Trial name
- NCT01123317
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
DSM-5 Schizophrenia
Impact of Caregiver Beliefs on Adherence to Antipsychotic Medications in Patients With Schizophrenia
Only one third of patients with schizophrenia are observant to their treatment knowing that the lack of adherence to treatment is one of the most important predictors of relapse.
- Trial name
- CroyAid-SCZ (NCT03471013)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Schizophrenia
Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Adolescent Patients With Schizophrenia
The purpose of this study is to demonstrate efficacy and safety of quetiapine fumarate (SEROQUEL) compared with placebo in the treatment of adolescent patients with schizophrenia.
- Trial name
- ANCHOR 112 (NCT00090324)
- Testing
- quetiapine fumarate tablets
- Where
- 42 sites in United States, Germany and 8 more
- Volunteers
- 249 people
- Sponsor
- AstraZeneca
Schizophrenia
Paliperidone Extended-Release (ER) Versus Risperidone for Neurocognitive Function in Patients With Schizophrenia
Primary objective: To examine whether the switch to paliperidone ER from risperidone improves cognitive function in stabilized patients with schizophrenia.
- Trial name
- NCT00827840
- Testing
- Paliperidone ER, Risperidone
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Chonnam National University Hospital
Schizophrenia
Imaging Dopamine D2 Agonist Binding Sites in Schizophrenia
The goals of this study is to determine (1) if differences in D2/3 receptor affinity states exist between medication-free subjects with SCH (MF-S) compared with healthy controls (HC), (2) the degree to which pre- and…
- Trial name
- NCT03999190
- Testing
- NPA radiotracer, Raclopride radiotracer, Dextroamphetamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Schizophrenia
Study to Evaluate the Efficacy and Safety of Risperidone ISM® in Patients With Acute Schizophrenia: Open Label Extension
This is the long-term open label extension (OLE) of the study PRISMA-3 (NCT03160521). Those patients who complete participation in the main segment of the study (double blind) together with other clinically stable not previously…
- Trial name
- PRISMA-3_OLE (NCT03870880)
- Testing
- Risperidone ISM 75 mg, Risperidone ISM 100 mg
- Where
- 24 sites in United States, Ukraine
- Volunteers
- 215 people
- Sponsor
- Rovi Pharmaceuticals Laboratories
Schizophrenia
Genetic Expression in Schizophrenics Treated With SSRI Augmentation: Relationship to Clinical and Cognitive Function
In our study we aim to examine the effect of SSRI augmentation on negative symptoms and cognitive function in schizophrenia patients as well as to examine the effect of SSRI augmentation on the RNA and protein products in…
- Trial name
- NCT00645580
- Testing
- Fluvoxamine
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Schizophrenia
Study Comparing Bioavailability of Oral Formulations of Vabicaserin
The purpose of this study is to determine the absorption rate of four oral formulations of vabicaserin.
- Trial name
- NCT00541996
- Testing
- vabicaserin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Schizophrenia, Schizophreniform Disorders
Investigating the Muscarinic System in Schizophrenia Using Positron Emission Tomography
Within the schizophrenia population, there are individuals that respond to first-line antipsychotic treatments while others do not.
- Trial name
- NCT06278246
- Testing
- PET Scan
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Psychotic Disorders
The Role of Personal Identity in Psychotic Symptoms: a Study With the Repertory Grid Technique
Personal identity is being recently recognized as a core element for mental health disorders, with relevant clinical implications. However, scarcity of data exists on its role in schizophrenia and related disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Self
- Trial name
- NCT03820362
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- University of Barcelona
Schizophrenia
Relapse Prevention, RoW: Study to Evaluate Prevention of Relapse in Patients in Stable Chronic Schizophrenia Receiving Either Seroquel or Placebo
This study is being carried out to see if quetiapine (Seroquel) is effective in preventing patients from a schizophrenic relapse when studied for a long time (1 year) and if so, how it compares with non-active treatment.
- Trial name
- NCT00228462
- Testing
- Seroquel (quetiapine)
- Where
- 5 sites in Bulgaria, Poland
- Volunteers
- 197 people
- Sponsor
- AstraZeneca
Herpes Simplex, Schizophrenia
Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia
The effects of Valacyclovir (VAV) augmentation or placebo (PLA) as adjuncts to conventional antipsychotic drug treatment will be evaluated among patients with schizophrenia who have been exposed to herpes simplex virus type 1…
- Conditions
- Herpes Simplex, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT01794897
- Testing
- Experimental: Valacyclovir treatment
- Where
- India
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
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