Clinical trials: Schizophrenia and Disorders With Psychotic Features
Psychosis, First Episode Psychosis
Thermoregulation Among Individuals With First-episode Psychosis
The project will evaluate thermoregulatory processes among individuals with and without first-episode psychosis.
- Trial name
- NCT04369677
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nicholas Breitborde
Depressive Disorder, Major
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00208156
- Testing
- Mifepristone
- Where
- 13 sites in United States
- Volunteers
- 87 people
- Sponsor
- Corcept Therapeutics
Insomnia, Schizophrenia
Cognitive Behavioral Therapy for Insomnia (CBT-I) in Schizophrenia(SLEEPINS)
Sleep problems are pervasive in people with schizophrenia. In our study, our goal is to determine whether we can alleviate sleep symptoms and improve quality of life and well-being in patients with major psychiatric disorders…
- Conditions
- Insomnia, Schizophrenia, Schizoaffective Disorder
- Trial name
- SLEEPINS (NCT04144231)
- Testing
- iCBT-I, GCBT-I
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Schizophrenia
Non-Interventional Study of Participants With Newly Diagnosed Schizophrenia Treated With Paliperidone Palmitate
The primary objective of this study is to explore hospitalization (number, length and reasons for psychiatric hospitalizations) in young, adult, newly diagnosed schizophrenia participants during the first 12 months of treatment…
- Trial name
- NCT02532842
- Where
- 7 sites in Croatia, Russia and 1 more
- Volunteers
- 90 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Schizophrenia
Efficacy of Chronic Disease Self-management Program in People With Schizophrenia
This was a randomized controlled behavioral intervention trial to assess the efficacy of investigating program of chronic disease self-management program in people on schizophrenia patients conditions of depression, activities of…
- Trial name
- NCT04503954
- Testing
- Chronic disease self-management program, General psychiatric intervention
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Schizophrenia, Psychotic Disorders
Effect of Curcumin Add-On Therapy on Quality of Life and IL-1β Levels in Patients With Schizophrenia
This study aims to evaluate the effect of curcumin extract as an adjuvant therapy on quality of life and inflammatory markers in patients with schizophrenia receiving risperidone.
- Trial name
- CUR-SCZ (NCT07523256)
- Testing
- Curcumin, Risperidone 4mg/day
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Rinvil Renaldi
Schizophrenia
Investigation of Community Reablement on Instrumental Activities of Daily Living in People With Schizophrenia
This is a randomized controlled behavioral intervention trial to assess the efficacy of investigating program of Reablement-Instrumental Activities of Daily Living (RE-IADL) on schizophrenia patients at immediately and long-term.
- Trial name
- NCT04350775
- Testing
- RE-IADL, General community rehabilitation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Schizophrenia, Schizoaffective Disorder
Treatment of Negative Symptoms of Schizophrenia With Transcranial Magnetic Stimulation (TMS)
This study will test whether repetitive transcranial magnetic stimulation (rTMS) is helpful in treating negative symptoms and social deficits of schizophrenia.
- Trial name
- NCT00517075
- Testing
- Transcranial Magnetic Stimulation (TMS), repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Family Members, Healthy
The Effect Of Logotherapy-Based Psychoeducatıon Applıed To Famıly Members Of Indıvıduals Dıagnosıs Of Schızophrenıa
Objective: This study aimed to determine the effects of logotherapy-based psychoeducation applied to family members of individuals diagnosed with schizophrenia on meaning in life, hope, and depression, and to examine experiences…
- Trial name
- NCT06859112
- Testing
- logotherapy focused psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- aslı zeynep sipahi
Schizophrenia
The Efficacy of Computerized Cognitive Remediation Therapy for Chronic Schizophrenia
The study group received antipsychotic drugs combined with Computerized Cognitive Remediation Therapy (CCRT) for 4 times/week for 45 minutes each time. The control group only received antipsychotic drugs. For a total of 12 weeks.
- Trial name
- NCT03772951
- Testing
- Cognitive Remediation Therapy, Clozapine
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai Mental Health Center
Alzheimer's Disease, Schizophrenia
Optimisation of Antipsychotic Drug Use in Older People
Drugs such as amisulpride, known as antipsychotic drugs, are used to treat troublesome and distressing symptoms in older people.
- Trial name
- NCT01454453
- Testing
- Patients- dose titration
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- Institute of Psychiatry, London
Schizophrenia, Schizophrenic Disorder
Brief Hospitalization for Schizophrenia: Strategies to Improve Treatment Outcome
The goal of this research program is to implement a series of psychoeducational training classes designed to teach individuals with schizophrenia the importance of medication treatment, how to identify and manage medication side…
- Trial name
- NCT00018837
- Testing
- Community Re-Entry Program: What is Schizophrenia
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Depression, Psychosis
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic…
- Conditions
- Depression, Psychosis, Anhedonia
- Trial name
- PEEPS (NCT05282277)
- Testing
- Transdermal Estradiol, Micronized Progesterone, Raclopride C11
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia
Reboxetine Adjuvant Therapy for the Treatment of Schizophrenia
30 patients will randomly be selected and will be administered either reboxetine or a placebo. changes in cognition and behavior will be assessed by computer tests and scales during a six week study period.
- Trial name
- NCT00409201
- Testing
- reboxetine adjuvant therapy
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Abarbanel Mental Health Center
Schizophrenia, Auditory Hallucinations
A Pilot Double-blind Sham-controlled Trial of Repetitive Transcranial Magnetic Stimulation for Patients With Refractory Schizophrenia Treated With Clozapine
The primary outcome of this study is to evaluate the effects of low frequency subthreshold repetitive Transcranial Magnetic Stimulation applied to the left temporoparietal cortex of patients with refractory schizophrenia on the…
- Trial name
- NCT01015001
- Testing
- (1Hz) rTMS applied over the left temporoparietal cortex
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Smoking Behavior in Schizophrenia
Quetiapine Decreases Smoking in Patients With Chronic Schizophrenia
A single-blind switching study in which forty subjects currently being treated with risperidone will be randomly assigned to either stay on risperidone or switched to quetiapine.
- Trial name
- NCT00231101
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Arthur P. Noyes Research Foundation
Schizophrenia
A Study of Plasma Concentrations, Metabolism and Excretion of 14C-paliperidone After a Single Oral Dose
The purposes of this study are to investigate the metabolic pathways of paliperidone and excretion of paliperidone and its metabolites in healthy adult male volunteers, both CYP2D6 poor and extensive metabolizers, after…
- Trial name
- NCT00796029
- Testing
- 14C-paliperidone
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia
The Role of miR-30 Family Dysregulation in Response to Antipsychotic Treatment
The aberrant expression of micro-RNAs (miRNAs) has been described in many human diseases, including schizophrenia (SZ). The previous work has indicated a strong genetic association between the miRNA-30e precursor (pre-miR-30e)…
- Trial name
- NCT02650102
- Testing
- Risperidone, Olanzapine, Quetiapine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanxi Medical University
Mental Health, Oral Health Care
The Mouth Matters in Mental Health Trial -2
This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment.
- Conditions
- Mental Health, Oral Health Care, Psychosis
- Trial name
- NCT07470437
- Testing
- Link work intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 480 people
- Sponsor
- Lancashire and South Cumbria NHS Foundation Trust
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