Clinical trials: Schizophrenia and Disorders With Psychotic Features
Bipolar Disorder, Psychotic Disorders
Determining the Safety and Effectiveness of Olanzapine in Children and Adolescents
This study will examine the safety and effectiveness of the antipsychotic drug olanzapine in children and adolescents with bipolar disorder or psychosis.
- Trial name
- NCT00183612
- Testing
- Olanzapine
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Massachusetts General Hospital
Psychoses, Substance-Induced
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Ketamine, an FDA approved anesthetic agent, is becoming the sedative/analgesic of choice for emergency sedation in children because it causes deep sedation with minimal respiratory depression in comparison to other available…
- Trial name
- NCT00205712
- Testing
- Ketamine, Dexmedetomidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Schizophrenia
Improving Cognition in Schizophrenia Using Non-invasive Brain Stimulation
This is a double-blind sham-controlled study to evaluate the effects of the combination of non-invasive brain stimulation, i.e. transcranial direct current stimulation (tDCS), with brief cognitive training (CT) on cognition in…
- Trial name
- NCT04184830
- Testing
- non-invasive brain stimulation
- Volunteers
- 49 people
- Sponsor
- King's College London
Psychosis
Compassion Focused Therapy for Distressing Experiences
This study aims to develop and test the feasibility of a new therapy called Compassion Focused Therapy (CFT) for psychosis. This therapy helps people with psychosis manage distressing experiences by building internal feelings of…
- Trial name
- NCT02733575
- Testing
- Compassion Focused Therapy
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- King's College London
Schizophrenia
A Physical Dependence Study in Schizophrenia
The purpose of this study is to determine whether or not people with schizophrenia who take LY2140023 become physically dependent on it, and experience a series of symptoms such as craving to have the drug when they stop using…
- Trial name
- NCT01452919
- Testing
- LY2140023
- Where
- 10 sites in United States, Greece
- Volunteers
- 123 people
- Sponsor
- Denovo Biopharma LLC
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Schizophrenia, Schizoaffective Disorder
Study of Amantadine for Risperidone Consta or Paliperidone Treated Patients to Decrease Prolactin Elevation
The purpose of this study is to show that amantadine might help to reduce the side effect of the medications which are prescribed to treat schizophrenia or schizoaffective disorder.
- Trial name
- NCT00975611
- Testing
- Amantadine Hydrochloride, USP
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- David C. Henderson, MD
Treatment-refractory Schizophrenia, Treatment-resistant Schizophrenia
Cognitive Behavioral Therapy for Sleep and Circadian Disturbances (CBT-I) in Treatment-Resistant Schizophrenia
Using a randomized controlled design, the project aims to test if cognitive behavioral therapy interventions specifically targeting sleep disorders can significantly lessen the burden of the disrupted sleep in patients with…
- Trial name
- COSTS (NCT06749444)
- Testing
- CBT-I, CBT
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Jimmi Nielsen
Mental Health, Psychotic Disorders
Monitoring and Management for Metabolic Side Effects of Antipsychotics
The purpose of this study is to test an approach for implementing guideline recommendations for assessing and managing metabolic side effects (including weight gain, diabetes, elevated lipids) in patients prescribed antipsychotic…
- Trial name
- AMMP (NCT01875861)
- Testing
- Evidence-Based Quality Improvement Plus Facilitation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
Early and Short Psycho-educational Lifestyle Intervention
People with severe mental illness have an increased risk of somatic comorbidities such as metabolic syndrome, obesity, hypertension, dyslipidemia and diabetes mellitus, which induce an increased risk of early mortality, mainly…
- Trial name
- HYVIE (NCT02657941)
- Testing
- Motivational group, educational group
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia
Metformin Treatment on Cognitive Impairment of Schizophrenia Co-morbid Metabolic Syndrome
In this study, the investigators will investigate the impact and the related mechanism of metformin treatment on cognitive impairment of schizophrenia with a high risk of metabolic syndrome.
- Trial name
- NCT03271866
- Testing
- metformin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Central South University
Schizophrenia, Psychotic Disorders
Role Functioning Changes NOS
During this study the investigators will 1) collect measures of social cognition and social functioning in adolescents and young adults who are experiencing early symptoms of a major mental disorder; and 2) evaluate the…
- Conditions
- Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- NCT02505022
- Testing
- Pharmacotherapy, Behavioral treatment
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Northwestern University
Schizophrenia
Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Negative Symptoms of Schizophrenia
This study was conducted to evaluate the efficacy, safety, and tolerability of AVP-786, as compared with placebo, for the treatment of negative symptoms of schizophrenia.
- Trial name
- NCT03896945
- Testing
- AVP-786
- Where
- 72 sites in United States, Bulgaria and 2 more
- Volunteers
- 136 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Schizophrenia
A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305)
This randomized, multi-center double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4917838 (bitopertin) in patients with sub-optimally controlled symptoms of schizophrenia.
- Trial name
- NCT01235559
- Testing
- bitopertin [RO4917838] level 1, bitopertin [RO4917838] level 2
- Where
- 90 sites in United States, Bulgaria and 5 more
- Volunteers
- 604 people
- Sponsor
- Hoffmann-La Roche
Schizophrenia and Related Disorders, Medication Adherence
Embedded Narrative in Interactive Game Design for Improving Medication Adherence of Schizophrenia
This study explores the potential of an interactive narrative game to enhance medication adherence among stable schizophrenia patients.
- Conditions
- Schizophrenia and Related Disorders, Medication Adherence, Mental Health Issue, Gamification
- Trial name
- NCT06175559
- Testing
- Healing Town: Embedded Narrative in Interactive Game (Psycho-education Tool) Design
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhu Dian
Schizophrenia
Study Comparing Bioavailability of Oral Formulations of Vabicaserin
The purpose of this study is to determine the absorption rate of four oral formulations of vabicaserin.
- Trial name
- NCT00541996
- Testing
- vabicaserin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Psychosis, Schizophrenia Disorders
HYEEG Discourse in Psychosis: A Neurobehavioural Study
This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify…
- Trial name
- DISCOURSE-NB (NCT06978803)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia
Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia
This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled.
- Trial name
- rTMS-FPCC (NCT04309370)
- Testing
- 20 Hz rTMS
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Schizophrenia
Schizophrenia for "Life" - a Registry and Interview Study Among Elderly With Lifelong Schizophrenia
The elderly demographic is on the rise - and this includes elderly living with schizophrenia. Yet very little is known about their lives, how they cope with their condition and how it develops over time.
- Trial name
- NCT02246283
- Where
- Denmark
- Volunteers
- 10,404 people
- Sponsor
- Kjeld Andersen
Affective Disorders, Psychotic Disorder
The Effects of Progressive Muscle Relaxation Therapy in Patients With Schizophrenia
This study applied a randomized parallel case-controlled design. The study purpose was to evaluate the effects of progressive muscle relaxation on anxiety, psychiatric symptoms and quality of life among patients with chronic…
- Trial name
- NCT03667729
- Testing
- progressive muscle relaxation
- Volunteers
- 75 people
- Sponsor
- Taipei Medical University
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