Clinical trials: Schizophrenia and Disorders With Psychotic Features
Autism Spectrum Disorders, Psychosis
Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment
The purpose of the proposed research is to study the potential changes in biomarkers of patients with neurodevelopmental disorders in response to treatment in clinical trials or in private psychiatry practice utilizing…
- Conditions
- Autism Spectrum Disorders, Psychosis, Fragile X Syndrome
- Trial name
- NCT01364818
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Schizophrenia and Related Disorders
Increasing Medication Check Participation Through Applying CT-r
The goal of this feasibility and acceptability trial is to learn about the acceptability of adding a recovery-oriented, psychological framework to a standard medication management appointment with a psychiatrist and any impact on…
- Trial name
- IMPACT (NCT06231407)
- Testing
- Recovery Oriented CBTp Medication Management, Treatment as Usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Schizophrenia, Schizoaffective Disorder
Efficacy and Tolerability of Switching to Ziprasidone From Other Antipsychotics
Because ziprasidone has not been extensively studied and is not widely accepted in the severely mentally ill in State hospitals this study aims to demonstrate its effectiveness and relative lack of side effects.
- Trial name
- NCT00458211
- Testing
- ziprasidone
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Bronx Psychiatric Center
Schizophrenia
Target Engagement of the Early Auditory Processing Network by Transcranial Direct Current Stimulation (tDCS)
Individuals with schizophrenia have difficulties in functioning in the community. No one really knows what factors determine how well patients manage in the real world.
- Trial name
- NCT02620267
- Testing
- tDCS Stimulation
- Volunteers
- 14 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Schizophrenia, Schizoaffective Disorder
Transcranial Current Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia
Investigating the effect of non-invasive transcranial current stimulation on auditory hallucinations in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Auditory Hallucinations
- Trial name
- NCT01963676
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Schizoaffective Disorder
Kuvan in People With Schizophrenia and Schizoaffective Disorder
Rater blinded trial of six weeks of Kuvan vs. multivitamin in 60 outpatients with schizophrenia or schizoaffective disorder. The aims are to evaluate an anticipated clinical response to Kuvan treatment including negative symptom…
- Trial name
- NCT01706965
- Testing
- Kuvan, Multivitamin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Schizoaffective Disorder
Effects of Risperidone and Olanzapine on Patients With Schizophrenia, Schizoaffective Disorder, Major Depression or Bipolar Disorder
This twelve month, open-label study considers the effect of Risperdal (risperidone) versus Zyprexa (olanzapine) on weight gain, physical health, and outcome in a population of those diagnosed with schizophrenia, schizoaffective…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Depressive Disorder, Major, Bipolar Disorder
- Trial name
- NCT00179062
- Testing
- olanzapine versus risperidone
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Schizophrenia
Study of CAD-9303 in Subjects With Schizophrenia
This study will consist of Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) cohorts that will be randomized, double-blind, and placebo-controlled to assess the safety, tolerability, and pharmacokinetics of CAD-9303.
- Trial name
- Affinity-1 (NCT04306146)
- Testing
- CAD-9303
- Where
- 2 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Cadent Therapeutics
Prodromal Symptoms, Prodromal Stage
HOPE TEAM - Clinical High Risk Group CBSST
Community-based treatments for adolescents at risk for psychosis are not widely available, nor are there established, gold-standard psychosocial group interventions for this population.
- Conditions
- Prodromal Symptoms, Prodromal Stage, Prodromal States, Psychosis
- Trial name
- NCT03738046
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Sponsor
- University of Pittsburgh
Schizophrenia
Study Evaluating Bifeprunox in Patients With Schizophrenia.
An open-label extension study using a variable dose (20 to 30 mg daily) of bifeprunox to evaluate long-term safety.
- Trial name
- NCT00366327
- Testing
- Bifeprunox
- Where
- 82 sites in United States
- Volunteers
- 400 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Treatment Resistant Schizophrenia Based on the DTMS
Exploration of the Deep Transcranial Magnetic Stimulation for Treatment Resistant Schizophrenia
Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia. Based on the hypothesis that deep transcranial magnetic stimulation(dTMS) on prefrontal cortex #PFC# could…
- Trial name
- NCT05167942
- Testing
- deep transcranial magnetic stimulation with H1 coil, High frequency deep transcranial magnetic stimulation with H1 coil, iTBS deep transcranial magnetic stimulation with H1 coil
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Healthy (Controls)
Exploring the Genetics of Schizophrenia in Manitoba
Schizophrenia is a serious mental illness that affects about 1 in 100 Canadians, shortens life expectancy, and places a large burden on individuals, families, and the healthcare system.
- Trial name
- GENES-MB (NCT07656870)
- Where
- Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Schizophrenia, Schizoaffective Disorder
The Effects of tDCS on Auditory Hallucination, Insight, Neurocognitive Function and HRV in Patients With Schizophrenia
The study aimed to investigate whether transcranial direct current stimulation could modify auditory hallucination, insight, neurocognitive function, heart rate variability, psychosocial functioning and quality of life in…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Auditory Hallucination, Verbal, Neurocognitive Dysfunction
- Trial name
- NCT03388554
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Schizophrenia, Psychotic Disorders
Recovery Therapy Trial
This project will systematically apply a specialist version of Cognitive Behaviour Therapy (CBT), known as Recovery Therapy, to a random sample of patients with psychotic disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders
- Trial name
- NCT00239122
- Testing
- Recovery Therapy (Cognitive Behaviour Therapy for psychosis)
- Where
- 2 sites in Australia
- Volunteers
- 94 people
- Sponsor
- Melbourne Health
Schizophrenia
Add-on Methotrexate for the Treatment of Schizophrenia
A recent double-blind placebo-controlled study has tested the effect of methotrexate as an add-on treatment for patients with schizophrenia or schizoaffective disorder, administering 10 mg of methotrexate or placebo once a week…
- Trial name
- NCT03369795
- Testing
- Methotrexate
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Schizophrenia
Attention Shaping Procedures for Improving Psychosocial Skills Among Adults With Schizophrenia
This study will evaluate the effectiveness of attention shaping procedures in improving attentiveness and learning abilities in people undergoing psychosocial skills training treatment for schizophrenia.
- Trial name
- NCT00391677
- Testing
- Social skills training with attention shaping procedures, Social skills training without attention shaping
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder)
Ultrasound Assessment of Gluteal Muscle in Patients Receiving Depot Antipsychotics and Healthy Volunteers
This observational study will use ultrasound to assess the gluteal musculature in patients receiving depot antipsychotic medication and in healthy volunteers.
- Conditions
- Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder), Intramuscular Injection
- Trial name
- ULPSYK (NCT07815587)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Schizophrenia, Exercise
Comparison of the Effects of Aerobic Exercise and Computerized Cognitive Stimulation in Patients With Schizophrenia - A Randomized Controlled Trial
Schizophrenia is a chronic mental disorder characterized by the occurrence of both positive symptoms, such as hallucinations and delusions, and negative symptoms, such as apathy and withdrawal, repetition of cognitive skills and…
- Conditions
- Schizophrenia, Exercise, Computerized Cognitive Stimulation
- Trial name
- NCT06572657
- Testing
- cognitive stimulation, physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Schizophrenia
Guideline vs Usual Treatment in Schizophrenic Adolescents
The purpose of this study was to evaluate the applicability and usefulness of the guideline treatment for diagnosis and treatment of adolescents with schizophrenia, also to evaluate the compliance to the treatment according to…
- Trial name
- ACER (NCT02573701)
- Testing
- Guideline treatment (Risperidone, administered orally), "Psychosocial treatment", Treatment as Usual (any other antipsychotic)
- Volunteers
- 91 people
- Sponsor
- Hospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico