Clinical trials: Schizophrenia and Disorders With Psychotic Features
Schizophrenia
Auditory Verbal Hallucinations in Schizophrenia
Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient…
- Trial name
- HAV (NCT01886417)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Schizophrenia
Treating Thought Problems in Patients With Schizophrenia
This study will compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment. This study will also determine whether the intensity of CAT can be reduced and still provide benefits to patients with schizophrenia.
- Trial name
- NCT00051740
- Testing
- Cognitive Adaptation Therapy (CAT), Minimal Environmental Supports (MES)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Schizophrenia
Antipsychotic Response in Schizophrenia
Motor slowing is a hallmark, clinical sign in mental illness. Slowness can be related to a specific disease process, as in negative schizophrenia or depression or it can be the result of medications used to treat forms of mental…
- Trial name
- NCT00018668
- Testing
- Risperidone, Olanzapine, Quetiapine
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Schizophrenia Disorder, Schizoaffecitve Disorder
DecNef for Auditory Verbal Hallucinations (AVH) in Schizophrenia
The purpose of this study is to learn whether a research neurofeedback training approach done during MRI scans may help reduce hallucinations such as the experience of hearing voices persistent despite treatment.
- Trial name
- DecNef (NCT07779226)
- Testing
- Decoded Neurofeedback
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Columbia University
Schizophrenia
Early Medication Discontinuation and Long-term Clinical Outcome in FEP
The study aims to examine the relationship between early maintenance therapy decisions in first episode psychosis, and the subsequent long-term clinical outcome at 9-10 years by comparing a group of patients who were randomized…
- Trial name
- FEP (NCT01926340)
- Where
- Hong Kong
- Volunteers
- 178 people
- Sponsor
- Professor Eric Y.H. Chen
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Clinical High Risk for Psychosis (CHR)
Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment.
- Trial name
- EM-PREPS (NCT06870305)
- Testing
- MBTP : Mindflulness based training for psychosis
- Where
- 2 sites in France
- Volunteers
- 270 people
- Sponsor
- Centre Psychothérapique de Nancy
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Psychosis, Suicidal
Acceptability and Feasibility of MOL in Acute Inpatient Units
The current study aims to test the acceptability and feasibility of a psychological therapy called Method of Levels (MOL) as an intervention for people in acute psychiatric inpatient units who are experiencing psychosis and/or…
- Trial name
- NCT05377294
- Testing
- Method of Levels therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Manchester
Bipolar Disorder, Affective Disorders, Psychotic
A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder
The purpose of this study is to determine the safety and efficacy of topiramate in adolescents with manic or mixed episodes of Bipolar I Disorder.
- Conditions
- Bipolar Disorder, Affective Disorders, Psychotic, Mood Disorders, Mental Disorders
- Trial name
- NCT00035802
- Testing
- Topiramate
- Volunteers
- 13 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia
Nicotine Effects on Endophenotypes of Schizophrenia
The purpose of this study is to test the effects of nicotine on cognition with the following schizophrenia endophenotypes: prepulse inhibition, antisaccades, the continuous performance test, spatial working memory and a verbal…
- Trial name
- NCT01315002
- Testing
- Transdermal nicotine patch
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Schizophrenia, Emotions
Emotional Response in Psychiatric and Control Participants
The purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health…
- Trial name
- NCT03056781
- Testing
- social interaction, food consumption
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Serious Mental Illness, Psychotic Disorder
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
People with serious mental illness (depression, bipolar, and schizophrenia spectrum disorders) have high rates of repeated criminal legal involvement and psychiatric hospitalizations.
- Conditions
- Serious Mental Illness, Psychotic Disorder, Depression, Bipolar
- Trial name
- CLCO-9 (NCT07359157)
- Testing
- Changing Lives and Changing Outcomes-9
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Psychosis
Method of Level (MOL) Therapy for Psychosis
The study is a systematic case replication series of a new psychological therapy Method of Levels (MOL) for people who experience psychosis. Between 6 and 8 people with psychosis who receive services from CMHT will be recruited.
- Trial name
- NCT04038112
- Testing
- psychological therapy Method of Levels (MOL)
- Volunteers
- 6 people
- Sponsor
- University of Manchester
Schizophrenia
Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
This study will determine the effectiveness of oral risperidone versus long-acting injectable risperidone in treating people with first-episode schizophrenia.
- Trial name
- NCT00330551
- Testing
- Oral Risperidone, Risperidone in Long-Acting Injectable Form (Consta)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia
Treatment of Schizophrenic Patients With Ziprasidone
To determine whether ziprasidone provides good efficacy and tolerability in the treatment of schizophrenic Greek patients.
- Trial name
- TRITON (NCT00579670)
- Testing
- Ziprasidone
- Where
- 20 sites in Greece
- Volunteers
- 450 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Schizophrenia
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES)
This PPG entitled "A Study on Psychopathological Progress of Early Schizophrenia-like Disorder (SOPRES)" is designed to study the "Progress of Psychopathology" of pre-psychotic state of schizophrenia (SCH) using a prospective…
- Trial name
- NCT00173069
- Volunteers
- 324 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia
Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)
The purpose of this study is to understand treatment preference and satisfaction among adults with schizophrenia in the United States who are prescribed xanomeline and trospium chloride (X/T) therapy
- Trial name
- NCT07101094
- Testing
- xanomeline and trospium chloride (X/T) therapy
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bristol-Myers Squibb
Schizophrenia
Efficacy and Safety of SEROQUEL Extended Release (XR) in Acute Schizophrenia
The purpose of the study is to determine whether treatment with quetiapine XR (Seroquel XR) tablets for 3 weeks will improve their agitation when they have acute psychosis.
- Trial name
- NCT00954122
- Testing
- Quetiapine XR (Seroquel XR)
- Where
- 2 sites in Malaysia
- Volunteers
- 35 people
- Sponsor
- AstraZeneca
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