Clinical trials: Schizophrenia and Disorders With Psychotic Features
Gambling Disorder, Psychotic Disorders
Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis
The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.
- Trial name
- ANTE-UP (NCT05686772)
- Testing
- Antipsychotic use, Psychiatric comorbidities, Sociodemographics/socioeconomic status
- Where
- 2 sites in Canada
- Volunteers
- 520 people
- Sponsor
- Laval University
Schizophrenia, Schizoaffective Disorder
Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia
The aim of the project is to investigate the use of Raloxifene (a new form of estrogen) in the treatment of young women with schizophrenia and schizoaffective disorder.
- Trial name
- NCT02354001
- Testing
- Raloxifene hydrochloride
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- The Alfred
Schizophrenia, Schizoaffective Disorders
Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine
The goal of this study is to answer the following questions: Whether treatment with amantadine, metformin or zonisamide can prevent or reverse the weight gain that is associated with olanzapine Whether taking amantadine…
- Trial name
- NCT00401973
- Testing
- olanzapine, amantadine, metformin
- Where
- 15 sites in United States, Brazil and 5 more
- Volunteers
- 199 people
- Sponsor
- Eli Lilly and Company
Schizophrenia
Twelve Month Study Comparing Paliperidone Palmitate and Select Oral Antipsychotics in Adults With Schizophrenia Who Have Been Recently Discharged From an Inpatient Psychiatric Hospital
The study will assess the use of paliperidone palmitate compared with oral antipsychotic treatment in delaying time to a protocol-defined treatment failure over 12 months, in patients diagnosed with schizophrenia who were…
- Trial name
- NCT01193166
- Testing
- paliperidone palmitate, risperidone, olanzapine
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Schizophrenia Disorder, Schizoaffective Disorder
Improving Health Literacy in Patients With Schizophrenia Spectrum Disorder
The Impact of Health Literacy on the Attitudes toward Pharmacological Treatment in Patients with Schizophrenia Spectrum Disorder This interventional study is aimed at: assessing and improving the health literacy and assessing the…
- Conditions
- Schizophrenia Disorder, Schizoaffective Disorder, Psychosis
- Trial name
- NCT07488156
- Testing
- Educational sessions
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Affective Disorders, Psychotic Disorder
The Effects of Progressive Muscle Relaxation Therapy in Patients With Schizophrenia
This study applied a randomized parallel case-controlled design. The study purpose was to evaluate the effects of progressive muscle relaxation on anxiety, psychiatric symptoms and quality of life among patients with chronic…
- Trial name
- NCT03667729
- Testing
- progressive muscle relaxation
- Volunteers
- 75 people
- Sponsor
- Taipei Medical University
Treatment Adherence and Compliance, Severe Mental Disorders
Medication Adherence in Severe Mental Illness: a Promotion Program
People living with serious mental illnesses such as schizophrenia and bipolar disorder often need long-term medication to stay well.
- Conditions
- Treatment Adherence and Compliance, Severe Mental Disorders, Bipolar Disorder (BD), Schizophrenia Disorder
- Trial name
- ADHERA (NCT07445802)
- Testing
- Telehealth Psychoeducational Adherence Program
- Volunteers
- 1,640 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Schizophrenia, Schizoaffective Disorder
Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
Treatment of schizophrenia currently includes antipsychotic medications and cognitive therapies which improve some symptoms, but do not sufficiently restore cognitive functioning or reduce psychosocial disability.
- Trial name
- NCT04857983
- Testing
- Memantine
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Participation, Patient, Psychiatric Hospitalization
Shared Decision Making in Psychiatric Inpatient Care
Introduction National guidelines and The Patient Act from 2014 call for an active role for the patient in the decision making process.
- Conditions
- Participation, Patient, Psychiatric Hospitalization, Psychosis
- Trial name
- DEAL (NCT04175366)
- Testing
- Shared Decision Making
- Where
- 2 sites in Sweden
- Volunteers
- 160 people
- Sponsor
- Umeå University
Schizophrenia
Study Evaluating SCA-136 in Subjects With Acute Exacerbations of Schizophrenia
The purpose of this study is to determine whether a low dose and a high dose of the study drug SCA-136 are effective and safe in the treatment of schizophrenia requiring hospitalization.
- Trial name
- NCT00265551
- Testing
- SCA-136 (200 mg), SCA-136 (400 mg), olanzapine (15 mg)
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Mood Disorders, Anxiety Disorders
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and multi-centre randomized clinical trial (RCT) to establish the benefits of pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in…
- Conditions
- Mood Disorders, Anxiety Disorders, Psychotic Disorders
- Trial name
- PSY-PGx (NCT05656469)
- Testing
- Personalised medication advice based on pharmacogenetic testing
- Where
- 9 sites in United States, Germany and 5 more
- Volunteers
- 2,500 people
- Sponsor
- Parnassia Groep
Bipolar I Disorder, Schizophrenia
Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects
To evaluate the long-term safety and tolerability of OLZ/SAM in pediatric subjects with schizophrenia or Bipolar I disorder
- Trial name
- NCT04987229
- Testing
- OLZ/SAM
- Where
- 35 sites in United States, Argentina and 3 more
- Volunteers
- 236 people
- Sponsor
- Alkermes, Inc.
Schizophrenia
[18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis
The first purpose of this study is to determine if dopamine synthesis capacity is significantly lower in treatment non-responders from illness onset relative to treatment responders.
- Trial name
- DPTP (NCT02880995)
- Testing
- PET scan, clinical scale, 6 weeks of treatment with amisulpride
- Where
- 2 sites in South Korea
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Psychotic Disorders, Schizophrenia Spectrum Disorders
Feasibility, Acceptability, and Preliminary Efficacy of Yoga-based Group Intervention for Outpatients With Schizophrenia Spectrum Disorders
A three-arm pilot rater-blinded randomized controlled trial is conducted, comprising Yoga-based Group Intervention (YoGI + TAU) as the experimental condition, a strength and flexibility training (SFT + TAU) group, and treatment…
- Trial name
- YOGIA (NCT07455929)
- Testing
- Yoga-based Group Intervention (YoGI) and treatment as usual (TAU), Strength and Flexibility Training (SFT) and TAU
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Schizophrenia
Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia
This is a pilot study of pregnenolone as an augmentation treatment for schizophrenia. The goal of this placebo-controlled study is to provide preliminary efficacy data for potential pregnenolone effects on cognitive symptoms and…
- Trial name
- NCT00560937
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Durham VA Medical Center
Schizophrenia
Role of Vitamin D Supplementation in Schizophrenia
The treatment of schizophrenia is challenging as the existing medications improve only the positive symptoms with the limited benefit on cognitive and negative symptoms which have a large bearing on the functional outcome.
- Trial name
- NCT03101319
- Testing
- Vitamin D3 cholecalciferol, B Complex Oral Tablet
- Where
- India
- Volunteers
- 73 people
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Schizophrenia, Bipolar Disorder
A Biological Signature for the Early Differential Diagnosis of Psychosis
Schizophrenia (SZ) and mood disorders (BD, MDD) are among the most disabling disorders worldwide, with a relevant social, functional, and economic burden.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT06515522
- Testing
- differential diagnosis
- Volunteers
- 1,850 people
- Sponsor
- IRCCS San Raffaele
Schizophrenia, Central Nervous System Diseases
Safety and Cognitive Function Study of EVP-6124 in Patients With Schizophrenia
This study is being conducted to determine the safety and effect on cognitive function of two different doses of an investigational medication, EVP-6124, in individuals with schizophrenia who are on chronic stable atypical…
- Conditions
- Schizophrenia, Central Nervous System Diseases, Cognition
- Trial name
- NCT00968851
- Testing
- EVP-6124
- Where
- 31 sites in United States, Russia and 2 more
- Volunteers
- 317 people
- Sponsor
- FORUM Pharmaceuticals Inc
Schizophrenia
ITI-007 (Lumateperone Tosylate) for Schizophrenia
The purpose of this study is to offer open label ITI-007 treatment to patients who poorly respond or poorly tolerate approved medications.
- Trial name
- NCT03817528
- Testing
- ITI-007
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Major Depression
Behavior During Experimentally Induced Pain
Numerous factors can influence the processing of pain message: the affective or emotional, the sensorial and the cognitive components.
- Trial name
- NCT01594528
- Testing
- pain tests
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Esquirol
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