Clinical trials: Schizophrenia and Related Disorders
Schizophrenia, Bipolar Disorder
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
The goal of this project, which has not changed, is to evaluate the statewide implementation of a two-component intervention (health promotion plus academic detailing) with respect to consumer outcomes and changes in provider…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT02334280
- Testing
- In SHAPE
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tobacco Dependence
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or…
- Trial name
- NCT03507127
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Schizophrenia
Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan
This proposal responds to Request for Applications RFA ( Rapid Founding Award)-MH ( Mental Health)-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the NIMH ( National Institute…
- Trial name
- S-TOGET (NCT01077687)
- Where
- Taiwan
- Volunteers
- 1,050 people
- Sponsor
- National Taiwan University Hospital
Mental Health
Patient Generated Goals in Mental Health: Better Outcomes?
Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they…
- Trial name
- NCT03527914
- Testing
- Goal Based Outcomes, Treatment as Usual
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Chronic Pain, Schizophrenia
CBT-CP for Veterans With SMI
Chronic musculoskeletal pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic musculoskeletal pain leads to poorer mental and physical health-related functioning, representing…
- Conditions
- Chronic Pain, Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- CP-SMI (NCT06758414)
- Testing
- Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Health & Wellness (H&W)
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
Exploring Hand Function in People With Schizophrenia Based on Perspective of Sensorimotor Control
The study aims to explore the hand function in people with schizophrenia in the chronic stage.
- Trial name
- NCT04941677
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- National Cheng-Kung University Hospital
Cannabis Use
Assessment of Cannabis Craving in Schizophrenia Using Virtual Reality
Background: Individuals with schizophrenia or schizoaffective disorders have a high prevalence of cannabis use. Understanding some of the environmental factors that maintain cannabis use, such as socially triggered cravings, is a…
- Trial name
- NCT01212081
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alzheimer Disease
Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)
The purpose of this study is to assess acceptability, and safety of providing tDCS to ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for ADRD-related symptoms, mainly behavioral symptoms.
- Trial name
- NCT05478681
- Testing
- active tDCS
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Psychotic Disorders, Schizophrenia and Related Disorders
EEG Outcomes From Cognitive Behavioural Therapy for Psychosis
Despite overwhelming evidence for neurocognitive and neurophysiological factors involved in the etiology of psychosis, these factors have never been examined as mechanisms of improvement from CBTp.
- Trial name
- EPIC (NCT05703698)
- Testing
- Cognitive Behavioural Therapy for Psychosis
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Schizophrenia, Bipolar Disorder
Resting State Electroencephalogram for Psychotic Disorders
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. Meanwhile, the increased appetite, which might related to self-control process, has been an increasing concern for…
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT05065489
- Testing
- No intervention
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Central South University
Depression, Schizophrenia
Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy
Electroconvulsive therapy (ECT) serves as an effective adjuvant or alternative modality for major depressive disorder, schizophrenia, or bipolar affective disorder refractory to or contraindicated to psychopharmacological…
- Conditions
- Depression, Schizophrenia, Bipolar Disorder, Cognitive Dysfunction
- Trial name
- NCT03863925
- Testing
- Target controlled infusion, Schnider model, Bolus injection of Propofol
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation.
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT05276050
- Testing
- active F8-coil delivered rTMS, active H-coil delivered rTMS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia, Alcohol Use Disorder
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
This double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
- Trial name
- NCT02161718
- Testing
- Samidorphan + olanzapine (ALKS 3831)
- Where
- 71 sites in United States, Bulgaria and 1 more
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Schizophrenia, Schizoaffective Disorder
Impact of Medication Education on Adherence and Side Effects
Severe mental disorders such as schizophrenia, bipolar disorder, and psychotic depression often require long-term or lifelong medication treatment.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder With Psychotic Features, Major Depressive Disorder With Psychotic Features
- Trial name
- MED-ADHERE (NCT07374588)
- Testing
- Medication Education Program, Routine Psychiatric Inpatient Care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Cumhuriyet University
Schizophrenia, Schizophreniform Disorders
Treatment of Schizophrenia With an Omega-3 Fatty Acid (EPA) and Antioxidants
The purpose of this trial is to study the effect of adding the omega-3 fatty acid EPA and/or Vitamins E + C to antipsychotic drugs in younger patients with schizophrenia and related psychoses.
- Conditions
- Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- NCT00419146
- Testing
- Ethyl-eicosapentaenoic acid (EPA), Vitamins E + C
- Where
- Norway
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aker
Bipolar Disorder, Schizophrenia
Recovery Group Pilot
The purpose of this study is to develop and evaluate a low-cost, joint consumer/counselor-led, health education and support intervention that will foster self-care and recovery among adults with serious mental illness.
- Conditions
- Bipolar Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT00522613
- Testing
- Recovery Group Project
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kaiser Permanente
Schizophrenia, Schizo Affective Disorder
Financial Incentives to Improve Medication Adherence
Medication adherence is a challenge in all of medicine and is associated with multiple negative outcomes. Strategies to better measure and enhance adherence to medication are urgent and necessary to minimize unwanted health…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder, Depression
- Trial name
- NCT04191876
- Testing
- Wellth - Financial Incentives
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Alcohol Abuse, Schizophrenia
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community…
- Conditions
- Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- CMETG (NCT01567943)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
Schizophrenia and Related Disorders, Anxiety Depression
Real-life Assessment of Abilify Maintena + Rexult in Schizophrenia
MainRexult study aims to carefully evaluate a cohort of patients with schizophrenia and related disorder prescribed with the combination therapy with Abilify Maintena and Rexulti on its efficacy and tolerability in a real-life…
- Trial name
- MainRexult (NCT05169268)
- Testing
- ARIPiprazole Injection [Abilify], Brexpiprazole
- Where
- Hong Kong
- Volunteers
- 6 people
- Sponsor
- The University of Hong Kong
Schizophrenia, Bipolar Disorder
Psychosocial Intervention to Reduce Self-stigma and Improve Quality of Life Among People With Mental Illness in Chile
The principal objective of this pilot trial is to evaluate the effectiveness of a psychosocial intervention to reduce self-stigma and improve treatment adherence and quality of life among people with a severe mental illness who…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03197168
- Testing
- Intervention to reduce self-stigma among people with mental illness, Control
- Where
- Chile
- Volunteers
- 76 people
- Sponsor
- University of Chile