Clinical trials: Schizophrenia and Related Disorders
Major Depressive Disorder, Schizo Affective Disorder
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
The goal of this study is to evaluate the effectiveness of an behavioral activation intervention to increase meaningful activity and community participation for people with serious mental illness.
- Conditions
- Major Depressive Disorder, Schizo Affective Disorder, Schizophrenia, Bipolar Disorder
- Trial name
- NCT06336616
- Testing
- Behavior Activation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Temple University
Schizophrenia, Bipolar Disorder
Time and Virtual Reality in Schizophrenia and Bipolar Disorder
Patients with bipolar disorders report an acceleration or slowing of time flow, and patients with schizophrenic spectrum disorders a time fragmentation. These disorders would be linked to disorders of the sense of self.
- Trial name
- VirtualTimes (NCT04432116)
- Testing
- virtual reality 1, virtual reality 2
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease, Schizophrenia
Multi-center Imaging Genetics Studies in China
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
- Conditions
- Alzheimer Disease, Schizophrenia, Major Depressive Disorders
- Trial name
- CHIMGEN (NCT02681822)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Severe Mental Illness, Schizophrenia
The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial
The investigators programme of research will evaluate an existing physical health care screening intervention with the aim of helping Community Psychiatric Nurses (CPN) to improve the physical health wellbeing of people with a…
- Conditions
- Severe Mental Illness, Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- CHIP (NCT02453217)
- Testing
- Chinese CHIP, Treatment as usual
- Volunteers
- 144 people
- Sponsor
- Wai-Tong Chien
Schizophrenia, Autism
Pediatric Open-Label Extension Study
This is an open-label, 104-week, multicenter, extension study designed to evaluate the long-term safety, tolerability and effectiveness of flexibly dosed lurasidone (20, 40, 60 or 80 mg/day) in pediatric subjects who have…
- Conditions
- Schizophrenia, Autism, Bipolar Depression
- Trial name
- NCT01914393
- Testing
- Lurasidone 20, 40, 60, 80 mg, flexibly dosed
- Where
- 88 sites in United States, Bulgaria and 13 more
- Volunteers
- 702 people
- Sponsor
- Sumitomo Pharma America, Inc.
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia, Schizo Affective Disorder
Transcranial Weak Current Stimulation Treatments for Working Memory Dysfunction in Schizophrenia
For the present study, Investigators will examine the efficacy of active prefrontal anodal tDCS versus placebo (sham) interventions to treat WM dysfunction in schizophrenia.
- Trial name
- NCT04637724
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Israel
- Volunteers
- 33 people
- Sponsor
- Oded Meiron
Substance Use Disorder, Attention Deficit Disorder With Hyperactivity
tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia…
- Conditions
- Substance Use Disorder, Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, Schizophrenia
- Trial name
- tRND&SUDs (NCT01876524)
- Testing
- Transcranial Random Noise Stimulation
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Spanish Foundation for Neurometrics Development
Schizophrenia, Bipolar Disorder
Impact of Cognitive & Metacognitive Performance on Knowledge Learning When Conducting Therapeutic Education Programs
People with schizophrenia and bipolar disorder display alterations in cognition and metacognition. These alterations may have an impact on learning during therapeutic education programs.
- Trial name
- MetaCOGNITION (NCT04590300)
- Testing
- QUESTIONNAIRES
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Schizophrenia, Schizoaffective Disorder
Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia
In this trial, researchers aim to investigate if prolonged-release melatonin can facilitate the withdrawal of chronic benzodiazepine administration in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- SMART (NCT01431092)
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 86 people
- Sponsor
- Lone Baandrup
First-episode Psychosis
Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age.
- Trial name
- PEPAMARKER (NCT05384392)
- Testing
- Recorded interview, Clinical scales, Blood sample
- Where
- 5 sites in France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Brest
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Homeless Youth Study - Stepping Stone 2.0
Housing instability is both a cause and consequence of mental health problems. As such youth experiencing housing instability (e.g., homeless or marginally housed) have higher rates of mental health problems.Because of their…
- Trial name
- NCT03776422
- Testing
- Mobile self-help intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Schizophrenia and Related Disorders, Early Treatment-Resistance
The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Schizophrenia (SZ) affects approximately 4.5 million people across the European Union (EU) and is associated with annual healthcare and societal costs of 29 billion Euros.
- Trial name
- INTENSIFY SZ (NCT05958875)
- Testing
- Clozapine, Second-line Antipsychotics (treatment as usual)
- Where
- 13 sites in Austria, Germany and 3 more
- Volunteers
- 418 people
- Sponsor
- Dr. Inge Winter
Major Depressive Disorder, Bipolar Disorder
Taking Action for College Students
The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT06700902
- Testing
- Taking Action
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Temple University
Schizophrenia, Bipolar Disorder
A Pilot Randomised Controlled Trial of a Health Champion Intervention
This study is a pilot RCT to evaluate the effectiveness and implementation challenges of an intervention using volunteer 'Health Champions' matched with service users to support service their physical health goals.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT04124744
- Testing
- Health Champions intervention, Control group-treatment as usual
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College London
Mental Disorders, Severe, Schizophrenia and Related Disorders
A Trial of "Opening Doors to Recovery" for Persons With Serious Mental Illnesses
Insufficient community-based support after inpatient discharge for persons with serious mental illnesses (SMI) may lead to re-hospitalization, excessive criminal justice involvement, homelessness, and an inability to embrace…
- Conditions
- Mental Disorders, Severe, Schizophrenia and Related Disorders, Bipolar Disorder, Depressive Disorder
- Trial name
- ODR (NCT04612777)
- Testing
- Opening Doors to Recovery, Case Management, Intensive Case Management
- Volunteers
- 240 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Major Depressive Disorder
Effectiveness of Traditional Chinese Metacognitive Training (MCT) in Patients With Schizophrenia, Depression, or Bipolar Disorder Attending a Psychiatric Day Hospital in Taiwan
Schizophrenia is characterized by positive symptoms such as delusions and hallucinations, which significantly impact daily functioning.
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT07051746
- Testing
- Metacognitive Training (MCT), Traditional Chinese version
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- ZI-YU LIN
Bipolar Disorder, Schizophrenia
Change in Brain Bioenergetics in Bipolar Disorder in Response to Photic Stimulation
This study aims to gather additional information to support the theory that bipolar disorder is due to cellular (mitochondrial) dysfunction.
- Conditions
- Bipolar Disorder, Schizophrenia, Healthy Controls
- Trial name
- NCT00801567
- Testing
- Magnetic resonance spectroscopy (MRS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Mental Health Issue, Anxiety Disorders
Arts-based Social Prescribing for Mental Health
This is a parallel-group randomised-controlled trial aiming to assess the effect of exposure to the arts on mental health and wellbeing of community dwelling recipients of mental health care.
- Conditions
- Mental Health Issue, Anxiety Disorders, Affective Disorders, Affective Disorders, Psychotic
- Trial name
- AoP-II (NCT07137572)
- Testing
- Art Prescription
- Where
- Greece
- Volunteers
- 541 people
- Sponsor
- KAVADIA ELENI
Severe Mental Illness, Schizophrenia
Integration of Illness Management and Recovery Within ACT
Integrating Illness Management and Recovery (IMR) into Assertive Community Treatment (ACT) has great promise for improving the symptomatic, functional, and recovery outcomes for people with Serious Mental Illness (SMI)…
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder
- Trial name
- ACT+IMR (NCT03075800)
- Testing
- Assertive Community Treatment (ACT) + Illness Management and Recovery (IMR)
- Volunteers
- 101 people
- Sponsor
- University of Washington