Clinical trials: Schizophrenia and Related Disorders
Severe Mental Disorders, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Severe Mental Disorders, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03837340)
- Testing
- CMHT, CAU
- Where
- Montenegro
- Volunteers
- 160 people
- Sponsor
- Special Psychiatric Hospital Kotor
Depression, Schizophrenia
Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy
Electroconvulsive therapy (ECT) serves as an effective adjuvant or alternative modality for major depressive disorder, schizophrenia, or bipolar affective disorder refractory to or contraindicated to psychopharmacological…
- Conditions
- Depression, Schizophrenia, Bipolar Disorder, Cognitive Dysfunction
- Trial name
- NCT03863925
- Testing
- Target controlled infusion, Schnider model, Bolus injection of Propofol
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Schizophrenia, Dual Diagnosis
Alcoholism and Schizophrenia: Effects of Clozapine
The purpose of this study is to examine the short - term effects of clozapine on alcohol use in persons with schizophrenia and an alcohol use disorder.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00169026
- Testing
- Clozapine versus typical (conventional) and atypical antipsychotic medications
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychosis, Mental Disorder
Assessment and Evolution of Narrative Identity and Its Relationship to Subjective Multidimensional Well-being and Multidimensional Recovery in First Episode Psychosis
First episode psychosis (FEP) constitutes an important subgroup within psychotic disorders, as the acute impact of a disorder at the time of diagnosis may differ from its long-term impact over the following decades.
- Trial name
- PEPID (NCT07330843)
- Testing
- Narrative identity task
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mental Disorder, Depressive Disorder
Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
A growing number of trials have demonstrated treatment effectiveness for mental illness by non-specialist providers, such as primary care providers, in low-resource settings.
- Conditions
- Mental Disorder, Depressive Disorder, Anxiety Disorder, Alcohol Use Disorder
- Trial name
- RESHAPE-cRCT (NCT04282915)
- Testing
- Reducing Stigma among Healthcare Providers (RESHAPE), mental health Gap Action Programme
- Where
- Nepal
- Volunteers
- 8,705 people, healthy volunteers welcome
- Sponsor
- George Washington University
Psychotic Disorders, Mood Disorders
Reproductive Life Planning for Women With Mental Illness
Women represent the fastest growing population within the VHA. Many are of reproductive age and experience mental health concerns.
- Conditions
- Psychotic Disorders, Mood Disorders, Stress Disorders, Post-Traumatic
- Trial name
- RLP-MH (NCT03969589)
- Testing
- Reproductive Life Planning-Mental Health (RLP-MH) Intervention, Written Materials on Reproductive Life Planning
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Schizoaffective Disorder
Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study
The purpose of this study is to get a better understanding of the side effect burden and identify predictors of psychotic, mood and aggressive disorders in children and adolescents.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychotic Disorder, Not Otherwise Specified
- Trial name
- SATIETY (NCT01269710)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of North Carolina, Chapel Hill
Second Generation Antipsychotic Induced Metabolic Adverse Effects
Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics
Schizophrenia and bipolar disorder are frequently associated with an elevated risk for obesity, metabolic syndrome, diabetes mellitus, dyslipidemia and other metabolic disturbances.
- Trial name
- NCT01811160
- Testing
- Melatonin
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Schizophrenia, Schizoaffective Disorder
Feasibility Electrical Stimulation Study for Visual Hallucinations
The visual system has increasingly been recognized as an important site of injury in patients with schizophrenia and other psychoses.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT04870710
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Schizophrenia, Schizoaffective Disorder
Virtual Reality Job Interview Training in Severe Mental Illness
This is a randomized controlled trial to evaluate the community-based effectiveness of virtual reality job interview training (VR-JIT). Northwestern University is partnering with Thresholds Inc.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depressive Disorder
- Trial name
- NCT03049813
- Testing
- Virtual Reality Job Interview Training, Supported Employment (Services as Usual)
- Where
- 4 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Michigan
Bipolar Disorder, Schizophrenia
Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity
Introduction 16.8% of the Danish adult population are obese (Body Mass Index> 30 kg / m2). Obesity increases the risk of lifestyle diseases such as type-2 diabetes and non-alcoholic fatty liver.
- Conditions
- Bipolar Disorder, Schizophrenia, Obesity, Circadian Rhythm Disorders
- Trial name
- SOMBER (NCT05413486)
- Testing
- Observational
- Where
- Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Schizophrenia, Mental Disorders
Effects of Delta-9-THC and Iomazenil in Healthy Humans
The study aims to examine the combined effects of delta-9-tetrahydrocannabinol (∆-9-THC or THC) and iomazenil on thinking, perception, mood, memory, attention, and electrical activity of the brain (EEG).
- Conditions
- Schizophrenia, Mental Disorders, Psychotic Disorders
- Trial name
- NCT00982982
- Testing
- THC and Iomazenil
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia Spectrum Disorder, PTSD
Childhood Maltreatment, Traumatic Experiences and Stress-associated Parameters in Schizophrenia Spectrum Disorders
Childhood maltreatment (CM) in psychotic disorders is associated with increased cognitive deficits, severe psychotic symptoms, and increased comorbidity.
- Trial name
- NETPSYCH (NCT03730831)
- Testing
- Narrative Exposure Therapy
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Konstanz
Schizophrenia
Cognitive Functioning Related to Job Tenure Among Patients With Schizophrenia
The aim of this research is to explore which cognitive function would affect the job tenure among people with schizophrenia. The investigators plan to recruit 60 people diagnosed with schizophrenia and divide into two groups…
- Trial name
- NCT00838123
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Schizophrenia, Schizoaffective Disorder
A Pharmacokinetic Study of Paliperidone ER
Background Paliperidone is an active metabolite of risperidone, both of which are antipsychotic agents for treatment of schizophrenia and related psychotic disorders.
- Trial name
- NCT02433717
- Testing
- Paliperidone ER
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Substance Abuse
Screening Protocol for Research Participants
The Screening Protocol is a system devised to evaluate potential research participants for National Institute on Drug Abuse/Maryland Psychiatric Research Center (NIDA/MPRC) studies.
- Conditions
- Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
- Trial name
- ScreenProt (NCT01010620)
- Testing
- Various Screening psychiatric and medical assessments
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bipolar Disorder, Schizophrenia
Trial to Assess the Bioavailability of Quetiapine Versus Seroquel® in Subjects With Schizophrenia or Bipolar Disorder
This is a two-part trial. The primary objective of Part A is to estimate the ratio of geometric means of pharmacokinetic (PK) parameters and their within-subject variability for the 300mg quetiapine tablet formulation A and the…
- Trial name
- NCT03872596
- Testing
- Seroquel IR 300mg, Seroquel IR 25mg, Quetiapine Formulation A 300mg
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Severe Mental Illness, Schizophrenia Spectrum &Amp; Other Psychotic Disorders
Validation and Impact of Cardiorespiratory Fitness in Severe Mental Illness - the Heart in Mind Project
This project aims to evaluate feasibility, validity and clinically applicability to systematically measure fitness in patients with severe mental illness. The research project is a validation study using a cross-sectional design.
- Conditions
- Severe Mental Illness, Schizophrenia Spectrum &Amp; Other Psychotic Disorders, Bipolar Affective Disorder
- Trial name
- NCT06743711
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bjorn H. Ebdrup
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Schizophrenia, Substance Use
Effects of Physical Activity in Psychosis
Physical health problems are common in schizophrenia with a two- to three-fold increased morbidity and mortality rate, resulting in a 20 years reduction in life expectancy.
- Trial name
- EPHAPS (NCT02205684)
- Testing
- Computer game skills training, Physical activity
- Volunteers
- 126 people
- Sponsor
- Sykehuset i Vestfold HF