Clinical trials: Schizophrenia and Related Disorders
Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Expanded Game Squad for Neurodiverse Youth
The proposed study will pilot the use of an adapted Game Squad intervention aimed at improving physical activity and other important health behaviors (nutrition, sleep hygiene, screen time habits) for children and adolescents…
- Conditions
- Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Health Behavior, Developmental Disorder
- Trial name
- NDGameSquad (NCT03665415)
- Testing
- NDGameSquad
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merrimack College
Schizophrenia, Schizoaffective Disorder
Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People
This study will evaluate the effectiveness of a health management and supported rehabilitation intervention in treating serious mental illnesses in older people.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00169052
- Testing
- Health Care Management and Supported Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Schizoaffective
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
This is a 15 week trial to determine (1) the safety and tolerability of varenicline when used for smoking cessation/reduction in individuals with schizophrenia; (2) if treatment with varenicline affects the symptoms of…
- Conditions
- Schizophrenia, Schizoaffective, Psychosis
- Trial name
- NCT00702793
- Testing
- Varenicline
- Sponsor
- University of British Columbia
Psychotic Disorders, ADHD
Cognitive Remediation in Forensic Mental Health Care
Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.
- Conditions
- Psychotic Disorders, ADHD, TBI (Traumatic Brain Injury), Aggression
- Trial name
- CRFMHC (NCT04610697)
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Depression, Bipolar Disorder
Peer Support Experience for Patients Discharged From Acute Psychiatric Care
The aim of the project is to conduct a four arm randomized controlled pilot trial to evaluate the effectiveness of an innovative peer support program that incorporates leadership training, mentorship, recognition, reward systems…
- Conditions
- Depression, Bipolar Disorder, Schizophrenia
- Trial name
- NCT03404882
- Testing
- Supportive/reminder text messaging plus peer support, Supportive/reminder text messaging, Peer support only
- Where
- 5 sites in Canada
- Volunteers
- 182 people
- Sponsor
- University of Alberta
Schizophrenia, Schizoaffective Disorder
Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI)
The major goal of this project is to adapt an existing group-based psychosocial program to enhance community functioning in older people with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00817154
- Testing
- HOPES-I
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression - Major Depressive Disorder, Schizophenia Disorder
A Novel Blood Test as a Biomarker in Mental Health
This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital…
- Conditions
- Depression - Major Depressive Disorder, Schizophenia Disorder, Psychosis, Mania (Neurotic)
- Trial name
- LEADING-MH (NCT06856161)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Fraser Health
Schizophrenia, Schizo-Affective Disorder
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
This is a study of the efficacy and safety of BXCL501 in children and adolescents with acute agitation and either bipolar disorder or schizophrenia.
- Conditions
- Schizophrenia, Schizo-Affective Disorder, Schizophreniform; Schizophrenic, Bipolar Disorder I
- Trial name
- NCT05025605
- Testing
- BXCL501 80 Micrograms, BXCL501 120 Micrograms, BXCL501 60 Micrograms
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- BioXcel Therapeutics Inc
Schizophrenia, Schizoaffective Disorder
Understanding How Cognitive Remediation Works
This study is aimed at evaluating whether the computer-based cognitive exercises in the Thinking Skills for Work (TSW) program are critical to improving work and cognitive outcomes in consumers with serious mental illness and…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Chronic Mental Disorder, Major Depression
- Trial name
- Cog-2 (NCT01683539)
- Testing
- The Thinking Skills for Work Program, The Cognitive Skills for Work Program
- Where
- 2 sites in United States
- Volunteers
- 203 people
- Sponsor
- Boston University Charles River Campus
Schizophrenia, Bipolar Disorder
Family Intervention for Mental Illness and Substance Abuse
This study will evaluate a family intervention program for individuals with bipolar disorder, schizophrenia, or schizoaffective disorder and co-occurring substance use disorders.
- Conditions
- Schizophrenia, Bipolar Disorder, Substance-related Disorders
- Trial name
- NCT00043693
- Testing
- Family Intervention for Dual Diagnosis, Family psychoeducation program
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia and Related Disorders, Mitochondrial Alteration
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
The goal of this double-blind, placebo-controlled randomized clinical trial is to test the effect of 12 weeks of orally administered MitoQ (mitoquinol mesylate) supplementation on cognition in 50 people with early phase…
- Conditions
- Schizophrenia and Related Disorders, Mitochondrial Alteration, Cognitive Impairment
- Trial name
- NCT06191965
- Testing
- MitoQ
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- Mclean Hospital
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Psychotic Disorders, Affective Disorder
Physical Activity, Psychopathology, and Quality of Life in People With Psychotic or Affective Disorders
This longitudinal observational study tests the associations between physical activity, health-related quality of life, and psychopathology symptoms among people diagnosed with schizophrenia or diagnosed with affective disorders.
- Trial name
- NCT05869409
- Testing
- Physical activity and sedentary behavior education
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Psychotic Disorders, Schizophrenia
FAST-A Study to Evaluate the Efficacy and Safety of Quetiapin IR in Patients With Acute Psychosis
The purpose of this study is to compare the efficacy of quetiapine IR, following rapid titration versus conventional titration in patients with acute psychosis
- Conditions
- Psychotic Disorders, Schizophrenia, Bipolar Disorder
- Trial name
- FAST (NCT00486798)
- Testing
- Quetiapine, Rating Scales, Self Assessment Form
- Where
- 13 sites in Sweden
- Sponsor
- AstraZeneca
Schizophrenia
Insight in Persons Presenting Schizophrenia or Related Troubles During Hospitalization in Psychiatry
Therapeutic alliance, and drug observance are major difficulties in the care of persons presenting schizophrenic symptomatology. They appear to be linked to insight, the consciousness that one has of his troubles.
- Trial name
- NCT01611337
- Testing
- insight variation measure
- Where
- 2 sites in France
- Volunteers
- 205 people
- Sponsor
- Centre Hospitalier Esquirol
Psychosis, SCHIZOPHRENIA 1 (Disorder)
Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis
Supporting people with psychosis to manage their emotions using virtual reality Many people who have experienced psychosis feel overwhelmed by their emotions. Emotions get in the way of doing what matters to them.
- Conditions
- Psychosis, SCHIZOPHRENIA 1 (Disorder), Schizophrenia and Related Disorders
- Trial name
- MANOEUVRE (NCT07623928)
- Testing
- MANOEUVRE therapy
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College London
Schizophrenia, Bipolar Disorder
Impact of Genetic Counseling for Individuals With Mental Illness
People who have experienced mental illnesses like schizophrenia, bipolar disorder or schizoaffective disorder often have a poor understanding of the causes of their illness, and that they are often very worried about how the…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT00713804
- Testing
- Genetic Counseling, Educational Booklet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Psychotic Disorders, Depressive Disorder, Major
Adolescent Mental Health: Canadian Psychiatric Risk and Outcome Study
The primary study aims are to determine the clinical, behavioural and social predictors of SMI development in youth, and to investigate whether neuroimaging can distinguish youth who will develop SMI from those who will not.
- Conditions
- Psychotic Disorders, Depressive Disorder, Major, Bipolar Disorder
- Trial name
- PROCAN (NCT02739932)
- Where
- 2 sites in Canada
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Schizophrenia, Schizophreniform Disorder
Association of Amisulpride Response in Schizophrenia With Brain Image
1. Study rationale - Nielsen et al reported that after 6 weeks of amisulpride treatment, patients with schizophrenia showed an increase in the anticipation-related functional MRI signal.
- Trial name
- ARB (NCT02095938)
- Testing
- amisulpride
- Volunteers
- 20 people
- Sponsor
- CHA University