Clinical trials: Schizophrenia and Related Disorders
Tobacco Dependence, Schizophrenia
The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia
Cigarette smoking represents a major health problem for patients suffering from schizophrenia. Compared to the general population, schizophrenic patients are significantly more likely to be addicted to nicotine.
- Trial name
- PSIAARP (NCT00495352)
- Testing
- Hihg-doseNRT, Low-dose NRT, bupropion
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- Yu-Li Hospital
Major Depressive Disorder (MDD), Schizophrenia
Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental Disorders
This is an observational study aiming to screen biomarkers associated with the diagnosis and treatment outcomes of severe mental disorders (MDD/major depressive disorder, SZ/schizophrenia, BD/bipolar disorder) through 7T…
- Conditions
- Major Depressive Disorder (MDD), Schizophrenia, Bipolar Disorder, Severe Mental Disorders
- Trial name
- NCT07479758
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nicotine Dependence
Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality
Background: The prevalence of cigarette smoking among individuals with schizophrenia is noticeably higher than in the general population, and smoking cessation attempts frequently are unsuccessful in this population.
- Trial name
- NCT01031433
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways
This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability.
- Trial name
- ButtomVP (NCT07469384)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Bipolar Disorder, Schizoaffective Disorder
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study.
- Conditions
- Bipolar Disorder, Schizoaffective Disorder, Manic Disorder, Mania
- Trial name
- NCT00431184
- Testing
- Pentazocine, Lorazepam
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mclean Hospital
Bipolar Disorder, Schizophrenia
A Non-Interventional Post-Marketing Surveillance Study to Evaluate the Safety and Efficacy of Zeldox Capsule
This is a regulatory-required non-interventional pharmacovigilance study exploring the safety profile of ziprasidone HCL monohydrate 20mg, 40mg, 60mg, 80mg in the real world patient population, thus, safety (and/or efficacy)…
- Trial name
- NCT01053429
- Testing
- ziprasidone
- Volunteers
- 3,391 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Schizophrenia
Cannabis and Thought Disorder in Schizophrenia
Recent studies have suggested a strong relationship between cannabis use and the level of thought disorder in subjects with schizophrenia.
- Trial name
- CANDI (NCT03608137)
- Testing
- Cannabis and thought disorder in schizophrenia:clinical and neuroimaging relationships
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia, Undifferentiated, Anorexia
Representations and Strategies for Recovery
In the recent context of deinstitutionalization and longitudinal studies pointing to a large number of positive long-term outcommes for people affected by a psychiatric disorder (schizophrenia, bipolar disorder, eating disorder…
- Conditions
- Schizophrenia, Undifferentiated, Anorexia, Bipolar Disorders, Personality Disorders
- Trial name
- EPR (NCT03028545)
- Testing
- Collection of the individual narrative, semi-directed interviews
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hôpital le Vinatier
Psychosis, SCHIZOPHRENIA 1 (Disorder)
Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis
Supporting people with psychosis to manage their emotions using virtual reality Many people who have experienced psychosis feel overwhelmed by their emotions. Emotions get in the way of doing what matters to them.
- Conditions
- Psychosis, SCHIZOPHRENIA 1 (Disorder), Schizophrenia and Related Disorders
- Trial name
- MANOEUVRE (NCT07623928)
- Testing
- MANOEUVRE therapy
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College London
Schizophrenia, Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
In this study, we will compare cue-reactivity in smokers with and without schizophrenia and the influence of smoking cues on responding for cigarette puffs under a PR schedule of reinforcement.
- Trial name
- NCT00770237
- Testing
- Smoking Cues, Neutral Cues
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia and Related Disorders, Sleep Disturbance
SPARK Healthy Sleep
SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems.
- Trial name
- SPARK (NCT07119268)
- Testing
- SPARK Healthy Sleep
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Indiana University
Supported Accommodation Residents, Schizophrenia, Shizotypal and Delusional Disorders
Quantitative Investigation of Environment and Participation
Supported accommodation provides individuals with complex mental health difficulties the opportunity to maintain a tenancy with different levels of staff support provided to develop and maintain living skills and engage in social…
- Conditions
- Supported Accommodation Residents, Schizophrenia, Shizotypal and Delusional Disorders, Mood Affective Disorders, Disorders of Adult Personality and Behavior
- Trial name
- QIEP (NCT04106960)
- Testing
- No Intevention Used
- Where
- United Kingdom
- Volunteers
- 235 people
- Sponsor
- Queen Margaret University
Stress Disorders, Traumatic, Depressive Disorder
The Immune System and Psychiatric Disorders
The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients…
- Conditions
- Stress Disorders, Traumatic, Depressive Disorder, Bipolar Disorder, Personality Disorders
- Trial name
- NCT00184418
- Where
- Norway
- Volunteers
- 1,400 people
- Sponsor
- Norwegian University of Science and Technology
Schizophrenia and Related Disorders, Psychotic Disorders
Exercise and Overnight Motor Sequence Task
The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the…
- Trial name
- EOMST (NCT03800368)
- Testing
- Exercise, Non-exercise
- Volunteers
- 51 people
- Sponsor
- The University of Hong Kong
Psychotic Disorders, Bipolar Disorder
Comparison of Aripiprazole Versus Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI
The purpose of this study is to compare abdominal weight gain and fat distribution in people taking aripiprazole versus risperidone or quetiapine, to people not taking any of these antipsychotic medications.
- Conditions
- Psychotic Disorders, Bipolar Disorder, Metabolic Syndrome X
- Trial name
- CALM (NCT01739127)
- Testing
- Aripiprazole, Risperidone/Quetiapine
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Schizophrenia, Schizoaffective Disorder
Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs
Background: Antipsychotics can induce metabolic disorders such as obesity, hyperglycemia, dyslipidemia or metabolic syndrome. It has been observed that treatment with antipsychotic could be accompanied by a decrease in the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02986490
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Psychotic Disorders, Psychological Trauma
Prevalence of Traumatic Events and PTSD in Immigrant and Non-immigrant Patients With Psychotic Disorder
Higher rates of psychosis are described in migrant population. Likewise, this populations could suffer several adversities during migration process that could lead to higher exposure to traumatic events and higher rates of…
- Conditions
- Psychotic Disorders, Psychological Trauma, Stress, Psychological, Cross-Cultural Comparison
- Trial name
- NCT04867447
- Testing
- Psychological trauma evaluation
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Parc de Salut Mar
Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Schizophrenia and Related Disorders
Substance Misuse To Psychosis for Stimulants
In Hong Kong, less than 5% of stimulants abusers were reported to misuse these substances via injection. Also, it is well known that patients with co-morbid substance abuse/dependence and psychosis or schizophrenia-related…
- Conditions
- Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Schizophrenia and Related Disorders, Stimulant Dependence, Stimulant Abuse
- Trial name
- NCT03485417
- Testing
- Aripiprazole, Paliperidone, Treatment as Usual
- Where
- Hong Kong
- Volunteers
- 165 people
- Sponsor
- The University of Hong Kong
Schizophrenia and Related Disorders
An Extension Protocol for Patients Who Previously Completed the TMS Pilot Study
This is an open-label extension study to continue to evaluate the safety, tolerability and efficacy of the Repetitive Transcranial Magnetic Stimulation (rTMS) in subjects with schizophrenia or schizoaffective disorder who…
- Trial name
- NCT05526833
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University
Schizophrenia, Chinese Han People
Mutation Screening and Translocation Detection of DISC1 Gene in Schizophrenia
Several chromosomal loci obtained from genetic linkage studies have been reported of relating to schizophrenia. These areas include of 1q32-41, 6p24-21, 8p22-21, 15q13-14, and 22q11-12.
- Trial name
- NCT00155818
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital