Clinical trials: Seasonal Malaria Chemoprevention
Malaria, Respiratory Infections
A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children
The primary objective of this study is to determine whether addition of azithromycin (AZ) to Seasonal Malaria Chemoprevention (SMC) using sulphadoxine/pyrimethamine (SP) +amodiaquine (AQ) will provide an additional reduction in…
- Trial name
- SMCAZ (NCT02211729)
- Testing
- Sulphadoxine-Pyrimethamine+ Amodiaquine+ Azithromycin
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 22,090 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study
We describe a Type II hybrid effectiveness-implementation study design which evaluates the effects of a clinical intervention on relevant outcomes whilst collecting information on implementation.
- Trial name
- NCT05186363
- Testing
- Chemopreventive Agent - SPAQ, Control Test - no drugs given
- Where
- 2 sites in Mozambique
- Volunteers
- 3,156 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Malaria, Anaemia
Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana
In areas of Africa where malaria is only a problem during a short rainy season, monthly courses of antimalarial drugs can provide very effective prevention of malaria in children.
- Trial name
- NCT01651416
- Testing
- Artemether-lumefantrine combination, Dihydroartemisinin Piperaquine combination, Amodiaquine plus sulphadoxine-pyrimethamine combination
- Where
- Ghana
- Volunteers
- 2,400 people
- Sponsor
- Centre for Global Health Research, Ghana
Malaria,Falciparum
Host Immune Dynamics Following Seasonal Malaria Chemoprevention in African Children
The study aims to identify immune features linked to protection against malaria, examining variations by age and sex, and measuring changes in immune responses over time following seasonal malaria chemoprevention (SMC).
- Trial name
- NCT06524336
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Malaria, Malnutrition, Child
Assessment of a Combined Strategy of SMC + Nutrients Supplementation to Tackle Malaria and Malnutrition
Malaria and malnutrition represent major public health concerns worldwide especially in Sub-Sahara Africa. Despite implementation of Seasonal Malaria Chemoprophylaxis (SMC), an intervention aimed at reducing malaria prevalence…
- Trial name
- SMC-NUT (NCT04238845)
- Testing
- AQSP Administration, Supplementation with Plumpy'Doz, Supplementation with Vitamin A
- Where
- Burkina Faso
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Malaria
Chemoprevention Efficacy Study in Burkina Faso
The aim of this study is to determine whether Seasonal Malaria Chemoprevention (SMC) remains effective in the health district of Nanoro in the Centre-Ouest region or Boussé in the Plateau Central region.
- Trial name
- NCT05478954
- Testing
- Sulfadoxine pyrimethamine, Amodiaquine
- Where
- Burkina Faso
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Malaria,Falciparum, Child, Only
Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study
A double-blind, individual randomised trial will be undertaken in children under five years of age living in areas of Burkina Faso or Mali where the transmission of malaria is intense and highly seasonal to determine whether…
- Trial name
- RTSS-SMC (NCT04319380)
- Testing
- Tetanus/diphtheria toxoids, SMC with SP+AQ, RTS,S/AS01
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 5,098 people
- Sponsor
- London School of Hygiene and Tropical Medicine