Clinical trials: Second Trimester Abortion
Pain Management, Abortion
Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement
The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.
- Conditions
- Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
- Trial name
- PCB-KinD (NCT07487246)
- Testing
- Ketorolac, oral ibuprofen, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rush University Medical Center
Abortion Early
Mid Trimester Abortion Effectiveness by Dilapan s
This study is done aiming to find out an effective method to induce second trimester abortion within a reasonable time and with the least possible cost and complications.
- Trial name
- NCT05147857
- Testing
- Dilapan s, Misoprostol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Second Trimester Abortion
Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion
Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion - a Double Blinded Randomized Controlled Trial
- Trial name
- NCT03044093
- Testing
- Mifepristone, Misoprostol
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Abortion Early, Abortion, Complete
Clotting Parameters After Medical Abortion
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
- Conditions
- Abortion Early, Abortion, Complete, Abortion, Second Trimester, Termination of Pregnancy Complicated by Embolism
- Trial name
- C-PLAN (NCT04824118)
- Testing
- Thromboelastometry, Clotting Studies, Full Blood Count
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Termination of Pregnancy Second Trimester
Misoprostol for Second Trimester Termination of Pregnancy
To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.
- Trial name
- MIMIS (NCT00945997)
- Testing
- misoprostol
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Second Trimester Abortion
Cervical Preparation With Mifepristone Prior to Osmotic Dilators
The investigators plan to study the role of mifepristone prior to the placement of cervical osmotic dilators to evaluate if the medication helps increase the number of dilators.
- Trial name
- NCT03714880
- Testing
- Mifepristone 200 MG
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pregnancy Termination
Second Trimester Pregnancy Termination With Foley Catheter
One of the methods used to induce second trimester pregnancy termination is the placement of a transcervical Foley catheter. The aim of this randomized controlled study was to assess in pregnant women with an unfavourable cervix…
- Trial name
- NCT03532503
- Testing
- Foley catheter
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Medical; Abortion, Fetus
Mifepristone and Misoprostol for 2nd Trimester Termination of Pregnancy in Burkina Faso
The goal of this study is to examine the effectiveness and feasibility of a mifepristone-misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Burkina Faso.
- Trial name
- NCT03269279
- Testing
- Mifepristone, Misoprostol
- Where
- 4 sites in Burkina Faso
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Second Trimester Medical Abortion
Paracervical Block During II-trimester Abortion
Paracervical blockage can reduce severe pain during second trimester induced medical abortion.
- Trial name
- NCT01617564
- Testing
- bipuvacain, NaCl
- Where
- 2 sites in Sweden
- Volunteers
- 112 people
- Sponsor
- Kristina Gemzell Danielsson
Therapeutic Abortion
Same-day Dilapan-S With Adjunctive Misoprostol
Cervical preparation before second trimester dilation and evacuation (D\&E) reduces risks and complications. Osmotic cervical dilators as well as prostaglandin analogues have been studied for cervical preparation.
- Trial name
- DAM (NCT01818414)
- Testing
- Misoprostol, Folic Acid
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pregnancy Trimester, Second, Induced Abortion
Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester
The purpose of this study is to compare two methods of pregnancy termination on the time to delivery in the second trimester.
- Trial name
- NCT00324519
- Testing
- Foley bulb, misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Abortion in Second Trimester
Outpatient Service for Mid-trimester Termination of Pregnancy
This study seeks to evaluate the safety, acceptability and feasibility of an outpatient "day procedure" for medical abortion at 13-18 weeks gestation.
- Trial name
- NCT03346629
- Testing
- Mifepristone + Misoprostol
- Where
- 3 sites in Nepal
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Induced
Pilot Study of the Addition of Osmotic Dilators to Preparation Prior to Labor Induction Abortion
One the day prior to medical abortion (labor induction) in the second trimester, insertion of osmotic dilators is added to the routine procedures.
- Trial name
- DAIS (NCT00855842)
- Testing
- osmotic dilator insertion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston University
Second Trimester Abortion
Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation
Primary objective: To study the difference in dilation and evacuation (D\&E) procedure time following overnight cervical preparation with laminaria or Dilapan-S™.
- Trial name
- NCT02033083
- Testing
- Laminaria, Dilapan-S
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Lactation Suppressed
A Reduced Dose of Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Pregnancy Loss
Most patients seeking abortion care or management of pregnancy loss in the second trimester will lactate, which can be physically and emotionally painful.
- Trial name
- LISTA3 (NCT06909123)
- Testing
- Cabergoline
- Sponsor
- Stanford University
Second Trimester Labor Induction
Second Trimester Labor Induction
A superior second trimester medical abortion regimen has not been identified. Studies suggest that a regimen of mifepristone and misoprostol given 36 to 48 hours apart has the shortest median induction-to-abortion interval…
- Trial name
- NCT00592215
- Testing
- Experimental (mifepristone and misoprostol)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Abortion, Missed
Amniotomy for Second-trimester Pregnancy Termination
The termination of abortion is an important issue that has many controversies. The most common time of serious abortion-related complications is the second trimester.
- Trial name
- NCT04906278
- Testing
- Foley catheter balloon, Amniotomy, Oxytocin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pregnancy Loss
Cervical Length on Pregnancy Termination
Cervical length is used as a parameter to predict cervical insufficiency and onset of labor. However, its role in predicting abortion induction is unclear.To investigate the impact of cervical length measurement and fetal…
- Trial name
- NCT04013035
- Testing
- cervical length measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Abortion in Second Trimester
OPIOID Study - Pain With Osmotic Dilators
Comparison of pain levels and pain medications utilized following insertion of two different types of osmotic dilators.
- Trial name
- OPIOID (NCT03710239)
- Testing
- Dilapan-S, Laminaria
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Cervical Incompetence
Cervical Occlusion Double-level Stitch Application
Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes…
- Trial name
- COSA (NCT05268640)
- Testing
- Double-level cervical cerclage, Single-level cervical cerclage
- Where
- 7 sites in Poland
- Volunteers
- 81 people
- Sponsor
- Centre of Postgraduate Medical Education