Clinical trials: Second Trimester Abortion
Second Trimester Abortion
Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia
This pilot study seeks to evaluate the safety, acceptability and feasibility of a shortened outpatient procedure for medical abortion at 13-18 weeks gestation.
- Trial name
- NCT04063904
- Testing
- Mifepristone, Misoprostol
- Where
- Colombia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Miscarriage
Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.
- Trial name
- NCT03479879
- Testing
- Estradiol, Misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Late Second Trimester Termination of Pregnancy
Vaginal Misoprostol and Foley Catheter for Late Second Trimester Termination of Pregnancy
Vaginal Misoprostol Versus Combined Low Dose Misoprostol Plus Foley Catheter for Late Second Trimester Termination of Pregnancy With Previous Multiple Cesarean Sections
- Trial name
- NCT02989324
- Testing
- MisoprostoL, Foley Catheter
- Where
- Egypt
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Abortion, Second Trimester
Transcervical Balloon Compared to Osmotic Dilators Prior to Surgical Abortion
The purpose of this study is to determine whether a Foley balloon is similar to osmotic dilators for preparing the cervix prior to a second trimester abortion.
- Trial name
- NCT05099991
- Testing
- Single Foley Balloon, Dilapan-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stanford University
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Arrhythmia, ECG Changes
Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy
In second trimester abortion above 22 weeks the investigators usually inject intra-cardiac Kcl for feticide. Digoxin intra-amniotic injection has been described in the literature in doses of 1-1.5 mg.
- Conditions
- Arrhythmia, ECG Changes, Hypotension
- Trial name
- NCT01951079
- Testing
- Intra-amniotic injection of DIGOXIN
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Medical; Abortion, Fetus
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia
This study included women who underwent voluntary second trimester termination of pregnancy. Patients were randomized to programmed intermittent epidural anesthetic bolus or continuous epidural infusion for pain analgesia.
- Trial name
- NCT01860521
- Testing
- Programmed Intermittent Epidural Bolus, Continuous Epidural Infusion, Procedure of interruption of pregnancy
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Placenta, Retained, Postpartum Hemorrhage
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00120042
- Testing
- Misoprostol, Oxytocin
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- The University of Western Australia
Termination of Pregnancy
Multi-Media E-Book for Second-Trimester Termination Due to Fetal Anomaly
The subjects of this study are married couples who received termination of pregnancy, the main purpose is to explore the effectiveness of the e-book education model.
- Trial name
- NCT04303949
- Testing
- Behavioral:
- Volunteers
- 96 people
- Sponsor
- China Medical University Hospital
Preterm Labor, Preterm Birth
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Premature Rupture of Membrane, Cervical Incompetence
- Trial name
- NCT03992534
- Testing
- LACTIN-V
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Abortion, Induced
Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14-21 Weeks LMP)
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00957346
- Testing
- Mifepristone+misoprostol
- Where
- Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Fibroid, Miscarriage in First Trimester
Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population
The aim of this observational study is to whether fibroids increase the risk of miscarriage in women in our early pregnancy population.
- Conditions
- Fibroid, Miscarriage in First Trimester, Miscarriage in Second Trimester
- Trial name
- FiRM (NCT06986616)
- Where
- United Kingdom
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pain
Analgesia for 2nd Trimester Termination of Pregnancy
There has been very little investigation into the management of pain from 2nd trimester termination of pregnancy or unexpected fetal loss.
- Trial name
- NCT01563835
- Testing
- bupivacaine, fentanyl, fentanyl
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Abortion,Induced
Comparison of Tramadol vs Remifentanyl Patient Controlled Analgesia for Second Trimester Abortions
Patients undergoing second trimester abortions will recieve either patient controlled analgesia with either remifentanyl or tramadol for pain alleviation. We beleive both to be equally effective for pain alleviation.
- Trial name
- NCT00361686
- Testing
- tramadol, remifentanyl, patient contolled analgesia
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Abortion, Second Trimester
24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
This study aims to compare mifepristone and buccal misoprostol to mifepristone and vaginal misoprostol for cervical preparation for second trimester dilation and evacuation (D\&E).
- Trial name
- NCT03134183
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Medical Abortion, Complete or Unspecified, Without Complication
Second Trimester Medical Abortion
The use of Mifepristone, an antiprogesterone, and Misoprostol together, has been shown to make the medial abortion process more efficient and reduce the induction-to-abortion interval by almost 50%.
- Trial name
- RAPM (NCT04160221)
- Testing
- 12 hours interval, 24 hours interval
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Contraception Behavior
Immediate vs. Delayed Insertion of Copper T 380A IUD After Termination of Pregnancy Over 12-weeks Gestation
The purpose of this study is to compare delayed vs. immediate insertion of the Copper T 380 IUD after termination of pregnancy after 12 weeks.
- Trial name
- NCT00540046
- Testing
- Copper T 380A IUD
- Where
- 2 sites in United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Abortion, Second Trimester
Induction of Abortion in the Second Trimester
To compare between the effects of misoprostol with hyoscine N-butyl bromide and misoprostol alone on shortening the time of abortion induction in the second trimester.
- Trial name
- NCT06207539
- Testing
- hyoscine N-butyl bromide under the generic name of buscopan ampoule produced by Sanofi company, misoprostol under the generic name of misotac tablets
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Second Trimester Abortion
Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections
it is a randomized controlled trial comparing the safety and efficacy of Vaginal Misoprostol versus combined Intracervical Foley's Catheter and Oxytocin Infusion for Second Trimester Pregnancy Termination.
- Trial name
- NCT04501809
- Testing
- compare misoprostol with combined oxytocin and cervical foly catheter
- Where
- 2 sites in Egypt
- Volunteers
- 158 people
- Sponsor
- Zagazig University
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine