Clinical trials: Secondary Headache Disorder
Traumatic Brain Injury, Headaches Posttraumatic
Adjunct VR Pain Management in Acute Brain Injury
Severe and refractory pain after acute injury is a known-risk factor for chronic opioid use disorder. In this study, the investigators will use Virtual Reality (VR) immersion as a non-pharmacological adjunct to treat pain…
- Conditions
- Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
- Trial name
- NCT04356963
- Testing
- Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Headache Disorders, Secondary, Brain Diseases
Hypersensitivity to Amylin in Post-Traumatic Headache
Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent…
- Conditions
- Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases
- Trial name
- NCT07340775
- Testing
- Amylin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Posttraumatic Headache
Hypersensitivity to Adrenomedullin in Post-Traumatic Headache
Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH)…
- Trial name
- NCT07059546
- Testing
- Adrenomedullin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Cervicogenic Headache
The Effects of a Specific Exercise Program on Subjects With Cervicogenic Headache
This study explores with the use of MSK Ultrasound imaging if the obliquus capitis minor and the rectus capitis major can be contracted with specific exercises.
- Trial name
- NCT05500378
- Testing
- Head extension and rotation movement
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Endocrine Disorder, Deficiency
Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal Therapy
The project will be conducted to investigate the hormonal homeostasis in men and women, with a special emphasis on sex hormones in men and AMH level in women, before and after withdrawal of the overused analgesics among MOH…
- Conditions
- Endocrine Disorder, Deficiency, Medication Overuse Headache, Migraine
- Trial name
- ENDOMOH (NCT04090333)
- Testing
- Standard withdrawal therapy
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Danish Headache Center
Post-Lumbar Puncture Headache
Headache After Diagnostic Lumbar Puncture
The objectives of this study are to investigate the effects of needle design, needle size and stylet reinsertion on the risk for headache after diagnostic LP (lumbar puncture, Post-LP headache).
- Trial name
- HELPUmeå (NCT03960749)
- Testing
- Sprotte 25G needle, stylet reinserted, Sprotte 25G needle, stylet not reinserted, Sprotte 22G needle, stylet reinserted
- Volunteers
- 1,000 people
- Sponsor
- Jonatan Salzer
Cervicogenic Headache, Occipital Neuralgia
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves at the top of the neck.
- Trial name
- NCT05491915
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- SPR Therapeutics, Inc.
Headache Disorders
Sustained Natural Apophyseal Glide and Deep Friction Massage in Patients With Cervicogenic Headache
The aim of this randomized controlled trial is to compare the effects of sustained natural apophyseal glide and deep friction massage in patients with cervicogenic headache for reducing pain, enhancing cervical range of motion…
- Trial name
- NCT05404113
- Testing
- sustained natural apophyseal glide, deep friction massage
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Cervicogenic Headache, Third Occipital Nerve
Effectiveness of Third Occipital Nerve Pulsed Radiofrequency in Cervicogenic Headache
Cervicogenic headache is a secondary headache disorder originating from cervical spine structures and is frequently associated with chronic pain, functional limitation, and impaired quality of life.
- Trial name
- TON-PRF-CH (NCT07366060)
- Testing
- Third Occipital Nerve Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ankara City Hospital Bilkent
Post-Dural Puncture Headache
Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache
Objectives: To compare the safety and efficacy of oral theophylline versus oral sumatriptan in the treatment of post-dural puncture headache (PDPH).
- Trial name
- NCT04257851
- Testing
- Theophylline Anhydrous Oral Tablet, Sumatriptan Succinate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Headache, Cervical Pain
Comparison of Kinesiology Taping and Instrument Assisted Soft Tissue Mobilization in Cervicogenic Headache
To compare the effects of kinesiology taping and Instrument Assisted Soft Tissue Mobilization in cervicogenic headache
- Trial name
- NCT05474612
- Testing
- kinesiology taping with conventional therapy, Instrument assisted soft tissue mobilization with conventional therapy
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cervicogenic Headache
Cervicogenic Headache, Cognitive Dysfunction
The goal of this study was to determine the frequency of cognitive dysfunction in patients with cervicogenic headache. participants will be asked questions to determine their cognitive status at once.
- Trial name
- NCT05572489
- Testing
- visual pain scale Beck depression scale Pain catastrophizing scale Short Form-36 Standard Mini mental test Montreal cognitive assessment scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Cervicogenic Headache
Traditional Chinese Cervical Manipulation for Cervicogenic Headache
Background Cervical spondylosis is a prevalent condition. Studies has shown that it is a leading cause for headache, which is termed cervicogenic headache (CGH). The prevlance of CGH among severe headache is 17.5%.
- Trial name
- NCT06434051
- Testing
- Traditional Chinese cervical manipulation
- Where
- 2 sites in Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Trauma, Head, Headaches Posttraumatic
Frequency Specific Microcurrent Therapy for Mild Traumatic Brain Injury
Patients with mild traumatic brain injury (mTBI) may experience spontaneous recovery within 7-10 days, but some continue to exhibit symptoms such as headache, dizziness, vertigo, poor concentration, and cognitive dysfunction.
- Conditions
- Trauma, Head, Headaches Posttraumatic, Dizziness, Brain Concussion
- Trial name
- NCT06245967
- Testing
- Frequency specific microcurrent therapy
- Volunteers
- 52 people
- Sponsor
- China Medical University Hospital
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Post-Dural Puncture Headache
Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial.
Post-dural puncture headache (PDPH) is a common and debilitating complication of spinal anesthesia in pregnant patients undergoing cesarean sections, with an incidence ranging from 0.5% to 2% (1).
- Trial name
- NCT06824025
- Testing
- lidocaine group ( nebulized lidocaine + saline) total volume 4 ml
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Minia University
Cervicogenic Headache
Comparison of the Effects of Mechanical Traction and Manual Traction on Cervicogenic Headache
52 people between the ages of 18-45 who were diagnosed with cervicogenic headache by the physician who applied to the Physical Medicine and Rehabilitation Department of Bursa VM Medical Park Hospital will be included in the…
- Trial name
- NCT05397977
- Testing
- mechanical traction group, manuel traction group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istinye University
mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Mindful RAVANS Study
This pilot study is testing a new treatment for people who still have frequent headaches months after a mild traumatic brain injury, with about half of the participants coming from military or veteran backgrounds.
- Conditions
- mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Headache
- Trial name
- RAVANS (NCT07872761)
- Testing
- Cala-RAVANS (Model CR-2)
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Post-Traumatic Headache, Concussion, Mild
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
To better understand the clinical characteristics and complex pathophysiological events that constitute persistent post-traumatic headache (PPTH) and to identify possible calcitonin gene-related peptide (CGRP) hypersensitivity in…
- Trial name
- NCT03791515
- Testing
- Calcitonin Gene-Related Peptide
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared.
- Trial name
- NCT06069791
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University