Clinical trials: Secondary Headache Disorders
Post-Dural Puncture Headache
Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries
Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%.
- Trial name
- NCT06729047
- Testing
- normal Saline, Neostigmine, Ketorolac
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Assiut University
Post-Dural Puncture Headache, Low Pressure Headache
Non-Luer Butterfly Needle With One-way Valve for the Epidural Blood Patch: Does it Alter Blood Clotting?
The Department of Health recommends using equipment which prevents wrong route drug administration. However, the epidural blood patch requires equipment that connects to the intravenous and epidural route.
- Trial name
- NCT03420352
- Testing
- Thromboelastography
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Mild Traumatic Brain Injury, Headaches Posttraumatic
SMART Concussion Trial: Symptom Management vs Alternative Randomized Treatment of Concussion Trial
Given the rising rates of concussion in youth ages 10-19 and the significant proportion of young people who remain symptomatic for months following concussion, research evaluating the efficacy of multifaceted treatment options…
- Conditions
- Mild Traumatic Brain Injury, Headaches Posttraumatic, Neck Pain, Dizziness
- Trial name
- SMART (NCT05446597)
- Testing
- Symptom-specific Headache Treatment, Symptom-specific Dizziness &/or Neck Pain Treatment, Multimodal Concussion Treatment
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Post-Traumatic Headache, Concussion, Mild
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
To better understand the clinical characteristics and complex pathophysiological events that constitute persistent post-traumatic headache (PPTH) and to identify possible calcitonin gene-related peptide (CGRP) hypersensitivity in…
- Trial name
- NCT03791515
- Testing
- Calcitonin Gene-Related Peptide
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Post-Traumatic Headache, Post-Concussion Syndrome
Post-traumatic Headache Multidisciplinary Study
The study will investigate the effect of pharmacological preventive treatment, education, physiotherapy and psychological counselling on the headache and associated symptoms in patients refered to the Danish Headache Center
- Trial name
- PTHMS (NCT05328635)
- Testing
- Candesartan
- Where
- Denmark
- Volunteers
- 58 people
- Sponsor
- Danish Headache Center
Headache Disorders, Secondary, Brain Diseases
Hypersensitivity to Amylin in Post-Traumatic Headache
Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent…
- Conditions
- Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases
- Trial name
- NCT07340775
- Testing
- Amylin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Post-Dural Puncture Headache
Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache
Dural puncture during neuroaxial procedures is the most frequent major complication that causes the development of post-dural puncture headache (PDPH) in 16%-86% of cases.
- Trial name
- NCT06470854
- Testing
- Nebulized Dexmedetomidine, Bilateral greater occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Medication Overuse Headache
Is Detoxification Needed in Medication-overuse Headache?
Medication-overuse headache (MOH) is a disabling condition, yet treatable. According to European guidelines and based on evidence, multidisciplinary detoxification is the first choice of treatment for MOH.
- Trial name
- DEFINE3 (NCT02993289)
- Testing
- Different well-known treatments
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Tension-Type Headache, Cervicogenic Headache
The Classification and Treatment of Myofascial Headache: a Cross-sectional Study and Randomized Controlled Trial.
This project comprises two studies; a cross-sectional study and a randomized controlled trial. 1. The goal of the cross-sectional study is to compare multiple outcome parameters in different headache types: tension type (TTH)…
- Conditions
- Tension-Type Headache, Cervicogenic Headache, Myofascial Headache
- Trial name
- COMPHAS_RCT (NCT06100588)
- Testing
- Dry Needling, Manual therapy
- Where
- Belgium
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cervicogenic Headache
SCM Muscle Released in Patients with Cervicogenic Headache
Sternocleidomastoid syndrome is often characterized by referred pain in other areas. Like all muscles, the SCM can develop tight, and non-contracting bands called trigger points that can refer pain elsewhere.
- Trial name
- NCT06733896
- Testing
- trigger point pressure, neck exercises
- Where
- Saudi Arabia
- Volunteers
- 52 people
- Sponsor
- Al-Zaytoonah University of Jordan
Post Dural Puncture Headache
Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients
Some patients develop headache after spinal anesthesia used during cesarean section. This condition is called post-dural puncture headache (PDPH). Early identification of patients at risk may improve patient care.
- Trial name
- NCT07497945
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Kocaeli University
Post-dural Puncture Headache
Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches (ESYBRECHE)
The aim of the study is to assess the efficacy and safety of Synacthène® versus placebo in the treatment of post-dural puncture syndrome in patients receiving epidural analgesia, spinal analgesia, or combined spinal-epidural…
- Trial name
- ESYBRECHE (NCT02813655)
- Testing
- Tetracosactide (Synacthène®)
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
PTSD, Military Activity
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members.
- Conditions
- PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder
- Trial name
- NCT05414708
- Testing
- Art Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Walter Reed National Military Medical Center
Hypotension After Neuraxial Anesthesia, Cesarean Section
Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality
The goal of this clinical trial is to compare three regional anesthesia techniques (spinal, epidural, and dural puncture epidural anesthesia) in healthy pregnant women undergoing planned (elective) cesarean delivery.
- Conditions
- Hypotension After Neuraxial Anesthesia, Cesarean Section, Anesthesia, Obstetrical, Post-Dural Puncture Headache
- Trial name
- NCT07883733
- Testing
- Spinal Anesthesia, Epidural Anesthesia, Dural Puncture Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cervicogenic Headache
Hamstring Active Release Technique in Cervicogenic Headache
It has been suggested that the suboccipital muscles are a causative factor in both cervicogenic neck pain and headache. Hamstrings and sub-occipital muscles are connected by a neural system and sub-occipital muscles pass through…
- Trial name
- NCT05658627
- Testing
- active release technique, conventional therapy
- Volunteers
- 60 people
- Sponsor
- Cairo University
Occipital Neuralgia, Headache
Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia
This study is a randomized controlled trial, assessing the effect of a single platelet rich plasma (PRP) injection in post traumatic (concussive) greater occipital neuralgia.
- Trial name
- NCT04051203
- Testing
- Autologous Platelet Rich Plasma Injection, Depo-Medrol and lidocaine, Normal Saline
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cervicogenic Headache
Effect of Shock Wave Therapy on Upper Trapezius Trigger Points in Patients With Cervicogenic Headache.
Control group will receive US, TENS, IR and exercises. The treatment group will receive the same program in addition to shock waves therapy. Patients will receive 3 sessions per week for 4 weeks.
- Trial name
- NCT05939583
- Testing
- Shock Wave Therapy, US, TENS, IR and exercises.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- October 6 University
Post Traumatic Headache
Brain Biomarkers w/Mind-Body Tx in Veterans With Post Traumatic Headache (PTH)
This project aims to develop and test structural and functional brain imaging biomarkers for improvement in chronic pain from a mind/body intervention perspective in a critical veteran population, namely veterans with post…
- Trial name
- MBSR-PTH (NCT02145117)
- Testing
- MBSR
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, Los Angeles
Cervicogenic Headache
Effectiveness of Dry Needling of the Sternocleidomastoid in Patients With Cervicogenic Headaches
Evaluating the benefit of dry needling of the sternocleidomastoid muscle in subjects with cervicogenic headaches.
- Trial name
- NCT03730896
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Florida Gulf Coast University
Headache, Migraine, Persistent Post Traumatic Headache
Validating a Modified COMPASS 31questionnaire for Treatment Outcomes
Eligible participants will complete the COMPASS 31 (year), modified COMPASS 31(one month) and the NSI (one month) questionnaires at baseline and complete the modified COMPASS 31 and the NSI after usual care of treatment.
- Conditions
- Headache, Migraine, Persistent Post Traumatic Headache, Cervicogenic Headache
- Trial name
- COMPASS (NCT05302479)
- Testing
- COMPASS 31 questionnaire
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brooke Army Medical Center